A tale of turns and cycles guiding to neural crest migration. An Interview with Prof. Roberto Mayor

2020 ◽  
Vol 52 ◽  
Author(s):  
Miguel L. Concha
Keyword(s):  
Neural Crest ◽  
Model Organisms ◽  
Personal Perspective ◽  
Graduate Studies ◽  
Developmental Biologist ◽  
Preimplantation Mouse ◽  
The Uk ◽  
Neural Crest Migration ◽  
Collective Locomotion ◽  
Scientific Achievements

Roberto Mayor is a prominent Chilean developmental biologist working in the UK and an advocate of the developmental biology discipline in Latin America. Roberto started as a preimplantation mouse developmental biologist during his undergraduate and graduate studies in Chile. Yet, he now uses Xenopus and zebrafish to elucidate the mechanisms that drive the directed collective locomotion of neural crest cells. What life events moulded the research career of Roberto across the years? This article addresses this question and provides a personal perspective on his scientific achievements. The story of Roberto is a mix of turns and cycles that ultimately guided him to the migrating neural crest. Turns that made him shift between model organisms and scientific topics.Cycles that drove him back and forth between Chile and the UK and which have connected his early studies as an undergraduate student with the most recent work of his lab. A big lesson that we can learn from the life of Roberto is that no matter how much you plan your life always serendipity plays a significant role. But you have to be alert and brave to take the opportunities that life offers you.

Unlock imagined: arts in criminal justice

2019 ◽  
Vol 1 (2) ◽  
pp. 131-143
Author(s):  
Alison Frater
Keyword(s):  
Criminal Justice ◽  
Criminal Justice System ◽  
Justice System ◽  
Interdisciplinary Approach ◽  
Personal Perspective ◽  
Theoretical Understanding ◽  
The Arts ◽  
Optimistic Picture ◽  
The Uk ◽  
Causes Of Crime

Starting with a personal perspective this piece outlines the place and role of the arts in the criminal justice system in the UK. It paints an optimistic picture, though an unsettling one, because the imagination and reflexiveness of the arts reveals a great deal about the causes of crime and the consequences of incarceration. It raises questions about the transforming impact of the arts: how the benefits could, and should, be optimised and why evaluations of arts interventions are consistent in identifying the need for a non-coercive, more socially focused, paradigm for rehabilitation. It concludes that the deeper the arts are embedded in the criminal justice system the greater the benefits will be, that a more interdisciplinary approach would support better theoretical understanding, and that increased capacity to deliver arts in the criminal justice system is needed to offer more people a creative pathway out of crime.

An experimental study on neural crest migration in Barbus conchonius (Cyprinidae, Teleostei), with special reference to the origin of the enteroendocrine cells

Development ◽  
1981 ◽  
Vol 62 (1) ◽  
pp. 309-323
Author(s):  
C. H. J. Lamers ◽  
J. W. H. M. Rombout ◽  
L. P. M. Timmermans
Keyword(s):  
Neural Crest ◽  
Neural Tube ◽  
Ganglion Cells ◽  
Neural Crest Cells ◽  
Enteroendocrine Cells ◽  
Pigment Cells ◽  
Transplantation Technique ◽  
Spinal Ganglion Cells ◽  
Neural Crest Origin ◽  
Neural Crest Migration

A neural crest transplantation technique is described for fish. As in other classes ofvertebrates, two pathways of neural crest migration can be distinguished: a lateroventral pathway between somites and ectoderm, and a medioventral pathway between somites and neural tube/notochord. In this paper evidence is presented for a neural crest origin of spinal ganglion cells and pigment cells, and indication for such an origin is obtained for sympathetic and enteric ganglion cells and for cells that are probably homologues to adrenomedullary and paraganglion cells in the future kidney area. The destiny of neural crest cells near the developing lateral-line sense organs is discussed. When grafted into the yolk, neural crest cells or neural tube cells appear to differentiate into ‘periblast cells’; this suggests a highly activating influence of the yolk. Many neural crest cells are found around the urinary ducts and, when grafted below the notochord, even within the urinary duct epithelium. These neural crest cells do not invade the gut epithelium, even when grafted adjacent to the developing gut. Consequently enteroendocrine cells in fish are not likely to have a trunkor rhombencephalic neural crest origin. Another possible origin of these cells will be proposed.

It is more different than you think: Art libraries in Germany and the UK

2021 ◽  
Vol 46 (4) ◽  
pp. 92-96
Author(s):  
Erica Foden-Lenahan
Keyword(s):  
Second Language ◽  
Personal Perspective ◽  
The Past ◽  
Anniversary Issue ◽  
Language Environment ◽  
The Uk

Firstly, it is an honour to be asked to contribute to this anniversary issue. AKMB is celebrating 25 years as an organization supporting and representing art and museum librarians and libraries (1). ARLIS/UK & Ireland celebrated 50 years in 2019 and the Art Libraries Journal (ALJ) celebrated 40 years in 2016, so I have spent a lot of my 7 years as editor of the ALJ reflecting on how far we have come. The past couple of generations have overseen tremendous achievements in the profession worldwide and these milestones are an opportunity to reflect on those changes and to look forward. This is a personal perspective and is intended to be (often) light-hearted, it also is limited to what I have observed within the limitations of having attained my education outside of Germany and of operating in a second language environment.

scholarly journals Analysis of genetic dominance in the UK Biobank

2021 ◽  
Author(s):  
Duncan S Palmer ◽  
Wei Zhou ◽  
Liam Abbott ◽  
Nik Baya ◽  
Claire Churchhouse ◽  
...  
Keyword(s):  
Complex Traits ◽  
Multiple Testing ◽  
Model Organisms ◽  
Systematic Evaluation ◽  
Hair Color ◽  
Phenotypic Variance ◽  
Additive Effects ◽  
Uk Biobank ◽  
Genome Wide ◽  
The Uk

In classical statistical genetic theory, a dominance effect is defined as the deviation from a purely additive genetic effect for a biallelic variant. Dominance effects are well documented in model organisms. However, evidence in humans is limited to a handful of traits, particularly those with strong single locus effects such as hair color. We carried out the largest systematic evaluation of dominance effects on phenotypic variance in the UK Biobank. We curated and tested over 1,000 phenotypes for dominance effects through GWAS scans, identifying 175 loci at genome-wide significance correcting for multiple testing (P < 4.7 × 10-11). Power to detect non-additive loci is much lower than power to detect additive effects for complex traits: based on the relative effect sizes at genome-wide significant additive loci, we estimate a factor of 20-30 increase in sample size will be necessary to capture clear evidence of dominance similar to those currently observed for additive effects. However, these localised dominance hits do not extend to a significant aggregate contribution to phenotypic variance genome-wide. By deriving a version of LD-score regression to detect dominance effects tagged by common variation genome-wide (minor allele frequency > 0.05), we found no strong evidence of a contribution to phenotypic variance when accounting for multiple testing. Across the 267 continuous and 793 binary traits the median contribution was 5.73 × 10-4, with unbiased point estimates ranging from -0.261 to 0.131. Finally, we introduce dominance fine-mapping to explore whether the more rapid decay of dominance LD can be leveraged to find causal variants. These results provide the most comprehensive assessment of dominance trait variation in humans to date.

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