scholarly journals Tumor blood vessel visualization

2011 ◽  
Vol 55 (4-5) ◽  
pp. 535-546 ◽  
Author(s):  
Jeannine Missbach-Guentner ◽  
Julia Hunia ◽  
Frauke Alves
Keyword(s):  
Blood Vessel ◽  
Tumor Blood Vessel

scholarly journals Prolyl 4‐hydroxylase subunit alpha 1 (P4HA1) is a biomarker of poor prognosis in primary melanomas, and its depletion inhibits melanoma cell invasion and disrupts tumor blood vessel walls

2020 ◽  
Vol 14 (4) ◽  
pp. 742-762 ◽  
Author(s):  
Johanna Eriksson ◽  
Vadim Le Joncour ◽  
Tiina Jahkola ◽  
Susanna Juteau ◽  
Pirjo Laakkonen ◽  
...  
Keyword(s):  
Blood Vessel ◽  
Melanoma Cell ◽  
Cell Invasion ◽  
Poor Prognosis ◽  
Tumor Blood Vessel ◽  
Vessel Walls

scholarly journals Vaccines Targeting Tumor Blood Vessel Antigens Promote CD8+ T Cell-Dependent Tumor Eradication or Dormancy in HLA-A2 Transgenic Mice

2012 ◽  
Vol 188 (4) ◽  
pp. 1782-1788 ◽  
Author(s):  
Xi Zhao ◽  
Anamika Bose ◽  
Hideo Komita ◽  
Jennifer L. Taylor ◽  
Nina Chi ◽  
...  
Keyword(s):  
T Cell ◽  
Blood Vessel ◽  
Transgenic Mice ◽  
Cd8 T Cell ◽  
Tumor Blood Vessel ◽  
Tumor Eradication

Abstract 5176: Imaging αvintegrin-GFP during tumor blood vessel interaction in the chick CAM

2012 ◽  
Author(s):  
Yasunori Tome ◽  
Naotoshi Sugimoto ◽  
Shuya Yano ◽  
Masashi Momiyama ◽  
Hiroki Maehara ◽  
...  
Keyword(s):  
Blood Vessel ◽  
Tumor Blood Vessel

scholarly journals Tumor Necrosis Factor-alpha Damages Tumor Blood Vessel Integrity by Targeting VE-Cadherin

2006 ◽  
Vol 244 (5) ◽  
pp. 781-791 ◽  
Author(s):  
Chandrakala Menon ◽  
Antoinette Ghartey ◽  
Robert Canter ◽  
Michael Feldman ◽  
Douglas L. Fraker
Keyword(s):  
Tumor Necrosis Factor ◽  
Blood Vessel ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Necrosis Factor Alpha ◽  
Tumor Blood Vessel ◽  
Factor Alpha ◽  
Vessel Integrity ◽  
Necrosis Factor

scholarly journals Development of Anti-tumor Blood Vessel Antibodies by Phage Display Method

2010 ◽  
Vol 130 (4) ◽  
pp. 479-485 ◽  
Author(s):  
Takuya YAMASHITA ◽  
Naoki UTOGUCHI ◽  
Ryo SUZUKI ◽  
Kazuya NAGANO ◽  
Shin-ichi TSUNODA ◽  
...  
Keyword(s):  
Blood Vessel ◽  
Phage Display ◽  
Tumor Blood Vessel

Defibrotide, an Endothelium Protecting and Stabilizing Drug, Has Anti-Angiogenic Potential In Vitro and In Vivo.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 3956-3956
Author(s):  
Guenther Eissner ◽  
Edward K. Geissler ◽  
Massimo Iacobelli ◽  
Reinhard Andreesen ◽  
Ernst Holler ◽  
...  
Keyword(s):  
Blood Vessel ◽  
Tube Formation ◽  
Blood Levels ◽  
Human Gastric Cancer ◽  
Blood Vessel Formation ◽  
Vessel Formation ◽  
Tumor Blood Vessel ◽  
Skin Fold

Abstract DF is a polydisperse mixture of single-stranded polydeoxyribunucleotides which is successfully used in the treatment of hepatic veno-occlusive disease and other endothelial disorders. Recent pre-clinical evidence suggests that DF might also have anti-neoplastic properties. We addressed the question whether this might be due to the prevention of tumor blood vessel formation (angiogenesis). The anti-angiogeneic potential of DF was tested in vitro (Matrigel™ tube formation and aortic ring assay) and in vivo (dorsal skin-fold chamber model). Our results show that DF quantitatively (100%) blocks tube formation of trans-differentiated human endothelial-like cells (ELC) at concentrations corresponding to pharmacologic DF blood levels (100 μg/mL). Similarly, the sprouting of rat aorta endothelial cells in Matrigel™ was prevented by nearly 100%, when DF was applied on a daily basis. In vivo tumor angiogenesis in a human gastric cancer (TMK-1) grown in skin-fold chambers (nude mice) was also attenuated on day 5 by DF, as measured by microvascular density. Although the exact mechanism of DF action remains to be elucidated, initial Western blotting results show that DF reduces phosphorylation-activation of p70S6 kinase, which is a key target in the PI3K/Akt/mTOR signaling pathway linked to endothelial cell and pericyte proliferation and activation. Taken together, our data suggest that while DF is known for its endothelium-protecting function, it also inhibits tumor blood vessel formation, and thus should be considered for further testing as an anticancer agent.

On target with tumor blood vessel markers

1997 ◽  
Vol 15 (12) ◽  
pp. 1243-1244 ◽  
Author(s):  
Bruce R. Zetter
Keyword(s):  
Blood Vessel ◽  
Tumor Blood Vessel

Incorporation of adult organ-derived endothelial cells into tumor blood vessel

2003 ◽  
Vol 306 (1) ◽  
pp. 219-224 ◽  
Author(s):  
Keiichi Koizumi ◽  
Yasuo Tsutsumi ◽  
Haruhiko Kamada ◽  
Yasuo Yoshioka ◽  
Masaki Watanabe ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Blood Vessel ◽  
Tumor Blood Vessel

scholarly journals A recombined fusion protein SP5.2/tTF induce thrombosis in tumor blood vessel

Neoplasma ◽  
2015 ◽  
Vol 62 (04) ◽  
pp. 531-540 ◽  
Author(s):  
S. LV ◽  
M. YE ◽  
X. WANG ◽  
Z. LI ◽  
X. CHEN ◽  
...  
Keyword(s):  
Blood Vessel ◽  
Fusion Protein ◽  
Tumor Blood Vessel
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