scholarly journals From the discovery of Vascular Endothelial Growth Factor to the introduction of Avastin in clinical trials - an interview with Napoleone Ferrara

2011 ◽  
Vol 55 (4-5) ◽  
pp. 383-388 ◽  
Author(s):  
Domenico Ribatti
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Clinical Trials ◽  
Growth Factor ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor

scholarly journals Anti-VEGF Treatment in Chronic Persistent Diabetic Macular Oedema

2018 ◽  
Vol 12 (1) ◽  
pp. 21
Author(s):  
Kevin J Blinder ◽  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Clinical Trials ◽  
Growth Factor ◽  
Treatment Regimen ◽  
Macular Oedema ◽  
Standard Treatment ◽  
Diabetic Macular Oedema ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor ◽  
Standard Treatment Regimen

We have seen the efficacy of anti-vascular endothelial growth factor (VEGF) therapy in the treatment of diabetic macular oedema (DMO) as demonstrated by the major clinical trials, but what do we do for those that respond poorly to the standard treatment regimen? Let’s discuss this issue and others as it pertains to the treatment of DMO.

scholarly journals Excess Soluble fms-like Tyrosine Kinase 1 Correlates With Endothelial Dysfunction and Organ Failure in Critically Ill Coronavirus Disease 2019 Patients

2020 ◽  
Author(s):  
Vincent Dupont ◽  
Lukshe Kanagaratnam ◽  
Antoine Goury ◽  
Gaël Poitevin ◽  
Mathieu Bard ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Clinical Trials ◽  
Growth Factor ◽  
Endothelial Dysfunction ◽  
Tyrosine Kinase ◽  
Organ Failure ◽  
Symptom Severity ◽  
Plasma Levels ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor

Abstract Excess soluble fms-like tyrosine kinase 1 (sFlt-1), a soluble inhibitor of vascular endothelial growth factor pathway, has been demonstrated to promote endothelial dysfunction. Here, we demonstrate that sFlt-1 plasma levels correlate with respiratory symptom severity, expression of endothelial dysfunction biomarker, and incidence of organ failure in coronavirus disease 2019 patients. Clinical Trials Registration NCT04394195.

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