scholarly journals Sare metal-organikoetan oinarritutako farmakoen liberazio sistemak: biomolekulak atxikitzeko funtzionalizazio estrategiak

2021 ◽  
Author(s):  
Leire Celaya Azcoaga ◽  
Arkaitz Fidalgo-Marijuan ◽  
Roberto Fernández de Luis
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Metal Organic Framework ◽  
Metal Organic ◽  
Organic Framework

Sare metal-organikoetan (MOF, metal-organic framework ingelesez) oinarritutako farmakoen liberazio kontrolaturako erabiltzen diren sistemak (DDS, drug delivery system ingelesez) orain arte erabilitako sistema tradizionalek aurkezten dituzten mugak gainditzeko gai dira. Izan ere, haien izaera hibridoa dela eta, bai sistema ezorganiko tradizionalek zein organikoek aurkezten dituzten abantailak batzeko gai dira, hauen desabantailak murriztuz. Lan honetan, DDSak sortzeko kontuan hartu beharreko ezaugarriak azaldu eta gero, MOF sareek DDS gisa erabiltzeko aurkezten dituzten ezaugarri nabarmengarrienak aipatuko dira. Azkenik, MOF egituretan biomolekulen atxikipen eta/edo askapen kontrolatua lortzeko erabiltzen diren bost funtzionalizazio estrategia nagusiak aztertuko dira.

A multifunctional metal–organic framework based tumor targeting drug delivery system for cancer therapy

Nanoscale ◽  
2015 ◽  
Vol 7 (38) ◽  
pp. 16061-16070 ◽  
Author(s):  
Xiao-Gang Wang ◽  
Zhi-Yue Dong ◽  
Hong Cheng ◽  
Shuang-Shuang Wan ◽  
Wei-Hai Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Tumor Targeting ◽  
Metal Organic Framework ◽  
Metal Organic ◽  
Organic Framework

A ZnO-gated porphyrinic metal–organic framework-based drug delivery system for targeted bimodal cancer therapy

2018 ◽  
Vol 6 (47) ◽  
pp. 7898-7907 ◽  
Author(s):  
Qiu-ge Zhao ◽  
Jing Wang ◽  
Yu-peng Zhang ◽  
Jing Zhang ◽  
An-na Tang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Metal Organic Framework ◽  
Metal Organic ◽  
Organic Framework

A ZnO-gated porMOF-AS1411 nanosystem was prepared and successfully used for drug delivery and synergistic bimodal cancer therapy.

Metal Organic Framework [Zn2(1,4-bdc)2(dabco)]n as Drug Delivery System

2013 ◽  
Vol 829 ◽  
pp. 247-250 ◽  
Author(s):  
Negar Motakef-Kazemi ◽  
Seyed Abbas Shojaosadati ◽  
Ali Morsali
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Body Fluid ◽  
Metal Organic Framework ◽  
Porous Metal ◽  
Loading Efficiency ◽  
Metal Organic ◽  
Solvothermal Conditions ◽  
Organic Framework

Porous metal organic framework (MOF) {Zn2(1,4-bdc)2(dabco)}n synthesized under solvothermal conditions. The MOF was used as the carrier matrices for drug delivery system. The ibuprofen as analgesic and anti-inflammatory drug with 0.6 nm molecule size as a model was entrapped into this new carrier with pores distribution of 1.85 nm. The ibuprofen loading efficiency was obtained by thermogravimetric analysis. The ibuprofen loading efficiency of 22% (w/w) was obtained for this MOF. The entrapped ibuprofen was released over several days by soaking the sample in the simulated body fluid (pH 7.4) at 37 °C. The ibuprofen concentrations were analyzed using UV-vis Spectrophotometer at a wavelength of 260 nm. The result of release reveals that this {Zn2(1,4-bdc)2(dabco)}n is suitable as drug delivery system.

Metal-organic framework MIL-101(Fe)-NH 2 functionalized with different long-chain polyamines as drug delivery system

2018 ◽  
Vol 93 ◽  
pp. 115-120 ◽  
Author(s):  
Miroslav Almáši ◽  
Vladimír Zeleňák ◽  
Peter Palotai ◽  
Eva Beňová ◽  
Adriana Zeleňáková
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Metal Organic Framework ◽  
Metal Organic ◽  
Long Chain ◽  
Organic Framework
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