Energetics and Oxidative Stress in Synaptic Plasticity and Neurodegenerative Disorders

2002 ◽  
Vol 2 (2) ◽  
pp. 215-232 ◽  
Author(s):  
Mark P Mattson ◽  
Dong Liu
Keyword(s):  
Oxidative Stress ◽  
Synaptic Plasticity ◽  
Neurodegenerative Disorders ◽  
And Oxidative Stress

Relationship between matrix metalloproteinase-9 and oxidative stress in drug-free male schizophrenia: a case control study

2016 ◽  
Vol 54 (3) ◽  
Author(s):  
Sivasankar Devanarayanan ◽  
Hanumanthappa Nandeesha ◽  
Shivanand Kattimani ◽  
Siddharth Sarkar
Keyword(s):  
Oxidative Stress ◽  
Synaptic Plasticity ◽  
Matrix Metalloproteinase ◽  
Disease Severity ◽  
Positive Association ◽  
Total Antioxidant Status ◽  
Serum Levels ◽  
Matrix Metalloproteinase 9 ◽  
Metalloproteinase 9 ◽  
And Oxidative Stress

AbstractDeregulation of synaptic plasticity and oxidative stress are reported to play a crucial role in the pathogenesis of schizophrenia. Matrix metalloproteinase-9 (MMP-9) is an extracellular protease involved in regulation of synaptic plasticity. Malondialdehyde (MDA) is a marker of lipid peroxidation which is elevated in schizophrenia. Earlier studies have reported polymorphism of MMP-9 and its association with schizophrenia. The present study was designed to assess the serum levels of MMP-9, MDA and total antioxidant status (TAS) and their association in schizophrenia.A total of 40 cases and 40 controls were included in the study. Serum MMP-9, MDA and TAS were estimated in all the subjects. Disease severity was assessed using Positive and Negative Syndrome Scale (PANSS).MMP-9 and MDA were significantly increased and TAS were significantly reduced in schizophrenia cases compared to controls. MMP-9 was positively correlated with MDA (r=0.353, p=0.025) and negatively correlated with TAS (r=−0.461, p=0.003). TAS was significantly correlated with total (r=0.322, p=0.043) and negative symptom scores (r=0.336, p=0.034). Higher MMP-9 levels were associated with previous exposure to antipsychotics (p=0.032).MMP-9 and oxidative stress were increased and correlate well with each other in schizophrenia cases. Though total oxidant status showed positive association with disease severity, MMP-9 and MDA were not associated with the severity of the disease.

scholarly journals Oxidative modification of glyceraldehyde-3-phosphate dehydrogenase influences its interaction with endogenous neuroprotector isatin

2016 ◽  
Vol 62 (2) ◽  
pp. 160-163 ◽  
Author(s):  
O.A. Buneeva ◽  
O.V. Gnedenko ◽  
M.V. Medvedeva ◽  
A.S. Ivanov ◽  
A.E. Medvedev
Keyword(s):  
Oxidative Stress ◽  
Surface Plasmon Resonance ◽  
Neurodegenerative Disorders ◽  
Redox State ◽  
Optical Biosensor ◽  
Oxidative Modification ◽  
Neuroprotective Agents ◽  
Putative Target ◽  
Parent Component ◽  
And Oxidative Stress

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a classical glycolytic redox sensitive enzyme, exhibits various non-glycolytic functions, which are considered to be especially important for progression of various neurodegenerative diseases. GAPDH binds isatin (indole-dione-2,3), an endogenous indole often used as a parent component in numerous derivatives demonstrating diverse pharmacological (including neuroprotector) activities. In this study we have investigated binding of intact and mildly oxidized GAPDH to immobilized isatin, using an optical biosensor technique, employing surface plasmon resonance (SPR), and the effect of isatin as a probe for this binding. Mild GAPDH oxidation by 70 mM H2O2 increased enzyme dissociation from immobilized isatin. Since GAPDH is considered as a putative target for various neuroprotector agents, this suggests that its redox state determines sensitivity to neuroprotective agents, and oxidative stress typical for various neurodegenerative disorders may significantly reduce pharmacological effectiveness of such compounds

Alterations in Synaptic Plasticity and Oxidative Stress Following Long-Term Paracetamol Treatment in Rat Brain

2019 ◽  
Vol 37 (2) ◽  
pp. 455-468 ◽  
Author(s):  
Laddawan Lalert ◽  
Wilawan Ji-au ◽  
Sirinapa Srikam ◽  
Tipthanan Chotipinit ◽  
Sompol Sanguanrungsirikul ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Synaptic Plasticity ◽  
Rat Brain ◽  
And Oxidative Stress

The Effect of Resveratrol on Neurodegenerative Disorders: Possible Protective Actions Against Autophagy, Apoptosis, Inflammation and Oxidative Stress

2019 ◽  
Vol 25 (19) ◽  
pp. 2178-2191 ◽  
Author(s):  
Mohammad H. Pourhanifeh ◽  
Rana Shafabakhsh ◽  
Russel J. Reiter ◽  
Zatollah Asemi
Keyword(s):  
Oxidative Stress ◽  
Neurodegenerative Disorders ◽  
Cell Damage ◽  
Current Evidence ◽  
Therapeutic Effects ◽  
Neuronal Function ◽  
Beneficial Effects ◽  
Cellular Processes ◽  
And Oxidative Stress

The prevalence of neurodegenerative disorders characterized by the loss of neuronal function is rapidly increasing. The pathogenesis of the majority of these diseases is not entirely clear, but current evidence has shown the possibility that autophagy, apoptosis, inflammation and oxidative stress are involved. The present review summarizes the therapeutic effects of resveratrol on neurodegenerative disorders, based on the especially molecular biology of these diseases. The PubMed, Cochrane, Web of Science and Scopus databases were searched for studies published in English until March 30th, 2019 that contained data for the role of inflammation, oxidative stress, angiogenesis and apoptosis in the neurodegenerative disorders. There are also studies documenting the role of molecular processes in the progression of central nervous system diseases. Based on current evidence, resveratrol has potential properties that may reduce cell damage due to inflammation. This polyphenol affects cellular processes, including autophagy and the apoptosis cascade under stressful conditions. Current evidence supports the beneficial effects of resveratrol on the therapy of neurodegenerative disorders.

scholarly journals Role of Nrf2 in Synaptic Plasticity and Memory in Alzheimer’s Disease

Cells ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1884
Author(s):  
Don A. Davies ◽  
Aida Adlimoghaddam ◽  
Benedict C. Albensi
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Synaptic Plasticity ◽  
Neurodegenerative Disorders ◽  
Nuclear Translocation ◽  
Antioxidant Response ◽  
Related Factor ◽  
Amyloid Aβ ◽  
Novel Therapeutic

Nuclear factor erythroid 2-related factor 2 (Nrf2) is an important transcription factor that reduces oxidative stress. When reactive oxygen species (ROS) or reactive nitrogen species (RNS) are detected, Nrf2 translocates from the cytoplasm into the nucleus and binds to the antioxidant response element (ARE), which regulates the expression of antioxidant and anti-inflammatory genes. Nrf2 impairments are observed in the majority of neurodegenerative disorders, including Alzheimer’s disease (AD). The classic hallmarks of AD include β-amyloid (Aβ) plaques, and neurofibrillary tangles (NFTs). Oxidative stress is observed early in AD and is a novel therapeutic target for the treatment of AD. The nuclear translocation of Nrf2 is impaired in AD compared to controls. Increased oxidative stress is associated with impaired memory and synaptic plasticity. The administration of Nrf2 activators reverses memory and synaptic plasticity impairments in rodent models of AD. Therefore, Nrf2 activators are a potential novel therapeutic for neurodegenerative disorders including AD.

Diabetes Impairs Synaptic Plasticity in the Superior Cervical Ganglion: Possible Role for BDNF and Oxidative Stress

2013 ◽  
Vol 51 (3) ◽  
pp. 763-770 ◽  
Author(s):  
K. H. Alzoubi ◽  
O. F. Khabour ◽  
I. A. Alhaidar ◽  
A. M. Aleisa ◽  
K. A. Alkadhi
Keyword(s):  
Oxidative Stress ◽  
Synaptic Plasticity ◽  
Superior Cervical Ganglion ◽  
Cervical Ganglion ◽  
And Oxidative Stress

Iron chelation as a potential therapy for neurodegenerative disease

2008 ◽  
Vol 36 (6) ◽  
pp. 1304-1308 ◽  
Author(s):  
Robert C. Hider ◽  
Yongmin Ma ◽  
Francisco Molina-Holgado ◽  
Alessandra Gaeta ◽  
Sourav Roy
Keyword(s):  
Oxidative Stress ◽  
Neurodegenerative Disorders ◽  
Rational Design ◽  
Chelation Therapy ◽  
Iron Chelation ◽  
Therapeutic Agents ◽  
Disease States ◽  
Pathological Conditions ◽  
Pharmacological Targets ◽  
And Oxidative Stress

Neurodegenerative disorders include a variety of pathological conditions, which share similar critical metabolic processes such as protein aggregation and oxidative stress, both of which are associated with the involvement of metal ions. Chelation therapy could provide a valuable therapeutic approach to such disease states, since metals, particularly iron, are realistic pharmacological targets for the rational design of new therapeutic agents.

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