Adverse Effect of a Presenilin-1 Mutation in Microglia Results in Enhanced Nitric Oxide and Inflammatory Cytokine Responses to Immune Challenge in the Brain

2002 ◽  
Vol 2 (1) ◽  
pp. 29-46 ◽  
Author(s):  
Mark P. Mattson ◽  
Jaewon Lee ◽  
Sic L. Chan
Keyword(s):  
Nitric Oxide ◽  
Adverse Effect ◽  
Inflammatory Cytokine ◽  
Presenilin 1 ◽  
Immune Challenge ◽  
Cytokine Responses ◽  
Presenilin 1 Mutation ◽  
The Brain

Temporal trends of circulating nitric oxide and pro-inflammatory cytokine responses ex vivo in intra-abdominal sepsis: results from a cohort study

2010 ◽  
Vol 60 (3) ◽  
pp. 289-297 ◽  
Author(s):  
Miriam Ojeda Ojeda ◽  
Hilev Larrondo Muguercia ◽  
Abel Magdariaga Figuerola ◽  
Alfredo Sánchez Valdivia ◽  
Ingrid Rodríguez Alonso ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cohort Study ◽  
Inflammatory Cytokine ◽  
Ex Vivo ◽  
Temporal Trends ◽  
Abdominal Sepsis ◽  
Cytokine Responses

Localization of the cGMP-dependent protein kinases in relation to nitric oxide synthase in the brain

1999 ◽  
Vol 17 (1) ◽  
pp. 45-55 ◽  
Author(s):  
A.E.-D El-Husseini ◽  
J Williams ◽  
P.B Reiner ◽  
S Pelech ◽  
S.R Vincent
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Protein Kinases ◽  
Dependent Protein ◽  
Oxide Synthase ◽  
The Brain

scholarly journals Genotoxic and oxidative effect of duloxetine on mouse brain and liver tissues

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Isela Álvarez-González ◽  
Scarlett Camacho-Cantera ◽  
Patricia Gómez-González ◽  
Michael J. Rendón Barrón ◽  
José A. Morales-González ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Dna Damage ◽  
Mouse Brain ◽  
Control Level ◽  
Dna Oxidation ◽  
Methyl Methanesulfonate ◽  
Control Group ◽  
Oxidative Potential ◽  
The Brain ◽  
Oxidative Effect

AbstractWe evaluated the duloxetine DNA damaging capacity utilizing the comet assay applied to mouse brain and liver cells, as well as its DNA, lipid, protein, and nitric oxide oxidative potential in the same cells. A kinetic time/dose strategy showed the effect of 2, 20, and 200 mg/kg of the drug administered intraperitoneally once in comparison with a control and a methyl methanesulfonate group. Each parameter was evaluated at 3, 9, 15, and 21 h postadministration in five mice per group, except for the DNA oxidation that was examined only at 9 h postadministration. Results showed a significant DNA damage mainly at 9 h postexposure in both organs. In the brain, with 20 and 200 mg/kg we found 50 and 80% increase over the control group (p ≤ 0.05), in the liver, the increase of 2, 20, and 200 mg/kg of duloxetine was 50, 80, and 135% in comparison with the control level (p ≤ 0.05). DNA, lipid, protein and nitric oxide oxidation increase was also observed in both organs. Our data established the DNA damaging capacity of duloxetine even with a dose from the therapeutic range (2 mg/kg), and suggest that this effect can be related with its oxidative potential.

A novel presenilin 1 mutation (Ser169del) in a Chinese family with early-onset Alzheimer's disease

2010 ◽  
Vol 468 (1) ◽  
pp. 34-37 ◽  
Author(s):  
Jifeng Guo ◽  
Jiaohua Wei ◽  
Shusheng Liao ◽  
Lei Wang ◽  
Hong Jiang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Early Onset ◽  
Presenilin 1 ◽  
Chinese Family ◽  
Presenilin 1 Mutation ◽  
Early Onset Alzheimer’S Disease

Novel presenilin 1 mutation (Ile408Thr) in an Italian family with late-onset Alzheimer’s disease

2016 ◽  
Vol 610 ◽  
pp. 150-153 ◽  
Author(s):  
Andrea Tedde ◽  
Antonella Bartoli ◽  
Irene Piaceri ◽  
Sara Ferrara ◽  
Silvia Bagnoli ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Late Onset ◽  
Presenilin 1 ◽  
Italian Family ◽  
Presenilin 1 Mutation
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