From Radial Glia to Pyramidal-Projection Neuron: Transcription Factor Cascades in Cerebral Cortex Development

2006 ◽  
Vol 33 (1) ◽  
pp. 033-050 ◽  
Author(s):  
Robert F. Hevner
Keyword(s):  
Transcription Factor ◽  
Cerebral Cortex ◽  
Radial Glia ◽  
Projection Neuron ◽  
Cerebral Cortex Development

scholarly journals The role of α-E-catenin in cerebral cortex development: radial glia specific effect on neuronal migration

2014 ◽  
Vol 8 ◽  
Author(s):  
Marie-Theres Schmid ◽  
Franziska Weinandy ◽  
Michaela Wilsch-Bräuninger ◽  
Wieland B. Huttner ◽  
Silvia Cappello ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Neuronal Migration ◽  
Radial Glia ◽  
Specific Effect ◽  
Cerebral Cortex Development

scholarly journals Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Susanne Laukoter ◽  
Robert Beattie ◽  
Florian M. Pauler ◽  
Nicole Amberg ◽  
Keiichi I. Nakayama ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Gene Function ◽  
Kinase Inhibitor ◽  
Projection Neuron ◽  
Genomic Locus ◽  
Cyclin Dependent Kinase Inhibitor ◽  
Cerebral Cortex Development ◽  
Intrinsic Gene ◽  
Distinct Cell ◽  
Growth Promoting

AbstractThe cyclin-dependent kinase inhibitor p57KIP2 is encoded by the imprinted Cdkn1c locus, exhibits maternal expression, and is essential for cerebral cortex development. How Cdkn1c regulates corticogenesis is however not clear. To this end we employ Mosaic Analysis with Double Markers (MADM) technology to genetically dissect Cdkn1c gene function in corticogenesis at single cell resolution. We find that the previously described growth-inhibitory Cdkn1c function is a non-cell-autonomous one, acting on the whole organism. In contrast we reveal a growth-promoting cell-autonomous Cdkn1c function which at the mechanistic level mediates radial glial progenitor cell and nascent projection neuron survival. Strikingly, the growth-promoting function of Cdkn1c is highly dosage sensitive but not subject to genomic imprinting. Collectively, our results suggest that the Cdkn1c locus regulates cortical development through distinct cell-autonomous and non-cell-autonomous mechanisms. More generally, our study highlights the importance to probe the relative contributions of cell intrinsic gene function and tissue-wide mechanisms to the overall phenotype.

scholarly journals Transformation of the Radial Glia Scaffold Demarcates Two Stages of Human Cerebral Cortex Development

Neuron ◽  
2016 ◽  
Vol 91 (6) ◽  
pp. 1219-1227 ◽  
Author(s):  
Tomasz J. Nowakowski ◽  
Alex A. Pollen ◽  
Carmen Sandoval-Espinosa ◽  
Arnold R. Kriegstein
Keyword(s):  
Cerebral Cortex ◽  
Radial Glia ◽  
Human Cerebral Cortex ◽  
Cerebral Cortex Development ◽  
Two Stages

scholarly journals Thyroid Hormone Action in Cerebellum and Cerebral Cortex Development

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Fabrice Chatonnet ◽  
Frédéric Picou ◽  
Teddy Fauquier ◽  
Frédéric Flamant
Keyword(s):  
Cerebral Cortex ◽  
Thyroid Hormone ◽  
Thyroid Hormones ◽  
Glial Cell ◽  
Nuclear Receptors ◽  
Target Genes ◽  
Cell Types ◽  
Hormone Action ◽  
Cerebral Cortex Development ◽  
Thyroid Hormone Action

Thyroid hormones (TH, including the prohormone thyroxine (T4) and its active deiodinated derivative 3,,5-triiodo-L-thyronine (T3)) are important regulators of vertebrates neurodevelopment. Specific transporters and deiodinases are required to ensure T3 access to the developing brain. T3 activates a number of differentiation processes in neuronal and glial cell types by binding to nuclear receptors, acting directly on transcription. Only few T3 target genes are currently known. Deeper investigations are urgently needed, considering that some chemicals present in food are believed to interfere with T3 signaling with putative neurotoxic consequences.

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