Effects of Prolonged Treatment With the Opiate Tramadol on Prodynorphin Gene Expression in Rat CNS

2006 ◽  
Vol 30 (3) ◽  
pp. 341-348 ◽  
Author(s):  
Sanzio Candeletti ◽  
Giuseppe Lopetuso ◽  
Rosalia Cannarsa ◽  
Chiara Cavina ◽  
Patrizia Romualdi
Keyword(s):  
Gene Expression ◽  
Prolonged Treatment ◽  
Prodynorphin Gene Expression ◽  
Rat Cns

Effects of the selective norepinephrine uptake inhibitor nisoxetine on prodynorphin gene expression in rat CNS

2004 ◽  
Vol 127 (1-2) ◽  
pp. 115-120 ◽  
Author(s):  
Manuela Di Benedetto ◽  
Denise Feliciani ◽  
Claudio D'Addario ◽  
Sari Izenwasser ◽  
Sanzio Candeletti ◽  
...  
Keyword(s):  
Gene Expression ◽  
Uptake Inhibitor ◽  
Norepinephrine Uptake ◽  
Prodynorphin Gene Expression ◽  
Rat Cns

Transcriptional modulation of transin gene expression by epidermal growth factor and transforming growth factor beta

1988 ◽  
Vol 8 (6) ◽  
pp. 2479-2483
Author(s):  
C M Machida ◽  
L L Muldoon ◽  
K D Rodland ◽  
B E Magun
Keyword(s):  
Gene Expression ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Prolonged Treatment ◽  
Transcriptional Level ◽  
Tgf Beta ◽  
Epidermal Growth ◽  
Growth Factor Beta

Transin is a transformation-associated gene which is expressed constitutively in rat fibroblasts transformed by a variety of oncogenes and in malignant mouse skin carcinomas but not benign papillomas or normal skin. It has been demonstrated that, in nontransformed Rat-1 cells, transin RNA expression is modulated positively by epidermal growth factor (EGF) and negatively by transforming growth factor beta (TGF-beta); other peptide growth factors were found to have no effect on transin expression. Results presented here indicate that both protein synthesis and continuous occupancy of the EGF receptor by EGF were required for sustained induction of transin RNA. Treatment with TGF-beta inhibited the ability of EGF to induce transin, whether assayed at the transcriptional level by nuclear run-on analysis or at the level of transin RNA accumulation by Northern (RNA) blot analysis of cellular RNA. TGF-beta both blocked initial induction of transin transcription by EGF and halted established production of transin transcripts during prolonged treatment. These results suggest that TGF-beta acts at the transcriptional level to antagonize EGF-mediated induction of transin gene expression.

scholarly journals Atypical prodynorphin gene expression in corticosteroid-producing cells of the rat adrenal gland.

1991 ◽  
Vol 88 (4) ◽  
pp. 1320-1324 ◽  
Author(s):  
R. Day ◽  
M. K. Schafer ◽  
M. W. Collard ◽  
S. J. Watson ◽  
H. Akil
Keyword(s):  
Gene Expression ◽  
Adrenal Gland ◽  
Prodynorphin Gene Expression

scholarly journals Gene expression of prohormone and proprotein convertases in the rat CNS: a comparative in situ hybridization analysis

1993 ◽  
Vol 13 (3) ◽  
pp. 1258-1279 ◽  
Author(s):  
MK Schafer ◽  
R Day ◽  
WE Cullinan ◽  
M Chretien ◽  
NG Seidah ◽  
...  
Keyword(s):  
Gene Expression ◽  
In Situ Hybridization ◽  
Hybridization Analysis ◽  
Proprotein Convertases ◽  
Rat Cns
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