A Novel Imaging Probe for In Vivo Detection of Neuritic and Diffuse Amyloid Plaques in the Brain

2004 ◽  
Vol 24 (2) ◽  
pp. 247-256 ◽  
Author(s):  
Nobuyuki Okamura ◽  
Takahiro Suemoto ◽  
Tsuyoshi Shiomitsu ◽  
Masako Suzuki ◽  
Hiroshi Shimadzu ◽  
...  
Keyword(s):  
Amyloid Plaques ◽  
Imaging Probe ◽  
In Vivo Detection ◽  
The Brain

IC-P-133: Near-infrared fluorescence probe X50 for in vivo detection of amyloid plaques in the brain

2011 ◽  
Vol 7 ◽  
pp. S62-S62
Author(s):  
Nobuyuki Okamura ◽  
Shozo Furumoto ◽  
Ryuichi Harada ◽  
Hiroyuki Arai ◽  
Kazuhiko Yanai ◽  
...  
Keyword(s):  
Near Infrared ◽  
Fluorescence Probe ◽  
Amyloid Plaques ◽  
Near Infrared Fluorescence ◽  
In Vivo Detection ◽  
The Brain

P2-320: 18F-labeled ethenyl-benzoxazole derivatives for in vivo detection of amyloid plaques in the brain

2006 ◽  
Vol 2 ◽  
pp. S335-S335
Author(s):  
Nobuyuki Okamura ◽  
Shozo Furumoto ◽  
Satoshi Ito ◽  
Yousuke Fujikawa ◽  
Manabu Tashiro ◽  
...  
Keyword(s):  
Amyloid Plaques ◽  
In Vivo Detection ◽  
The Brain

In vivo fluorescence imaging of β-amyloid plaques with push–pull dimethylaminothiophene derivatives

2015 ◽  
Vol 51 (96) ◽  
pp. 17124-17127 ◽  
Author(s):  
Hiroyuki Watanabe ◽  
Masahiro Ono ◽  
Hideo Saji
Keyword(s):  
Fluorescence Imaging ◽  
Amyloid Plaques ◽  
Fluorescent Imaging ◽  
Imaging Probe ◽  
In Vivo Fluorescence ◽  
In Vivo Fluorescence Imaging ◽  
Β Amyloid ◽  
The Brain

We report a newin vivofluorescent imaging probe, DTM-2, that can detect β-amyloid plaques in the brain.

Novel quinoxaline derivatives for in vivo imaging of β-amyloid plaques in the brain

2011 ◽  
Vol 21 (14) ◽  
pp. 4193-4196 ◽  
Author(s):  
Mengchao Cui ◽  
Masahiro Ono ◽  
Hiroyuki Kimura ◽  
Boli Liu ◽  
Hideo Saji
Keyword(s):  
In Vivo Imaging ◽  
Amyloid Plaques ◽  
Quinoxaline Derivatives ◽  
Β Amyloid ◽  
The Brain

P1-143: Specific in vivo detection of amyloid plaques in transgenic mice using bifunctional USPIO nanoparticles

2012 ◽  
Vol 8 (4S_Part_4) ◽  
pp. P156-P156
Author(s):  
Thomas Wisniewski ◽  
Jialin Li ◽  
Dung Minh Hoang ◽  
Hong Xu ◽  
Yanjie Sun ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Amyloid Plaques ◽  
In Vivo Detection

Noninvasive Detection of Misfolded Proteins in the Brain Using [11C]BF-227 PET

2013 ◽  
pp. 438-445
Author(s):  
Nobuyuki Okamura ◽  
Shozo Furumoto ◽  
Manabu Tashiro ◽  
Katsutoshi Furukawa ◽  
Hiroyuki Arai ◽  
...  
Keyword(s):  
Protein Misfolding ◽  
Protein A ◽  
Lewy Bodies ◽  
Protein Aggregates ◽  
Brain Regions ◽  
Postmortem Brain ◽  
In Vivo Detection ◽  
Misfolding Diseases ◽  
The Brain

Alzheimer’s disease (AD) and many other neurodegenerative disorders belong to the family of protein misfolding diseases. These diseases are characterized by the deposition of insoluble protein aggregates containing an enriched ß-sheet structure. To evaluate PET amyloid-imaging tracer [11C]BF-227 as an agent for in vivo detection of various kinds of misfolded protein, a [11C]BF-227 PET study was performed in patients with various protein misfolding diseases, including AD, frontotemporal dementia (FTD), dementia with Lewy bodies (DLB), sporadic Creutzfeldt-Jakob disease (sCJD) and Gerstmann-Sträussler-Scheinker disease (GSS). BF-227 binds to ß-amyloid fibrils with high affinity. Most of the AD patients showed prominent retention of [11C]BF-227 in the neocortex. In addition, neocortical retention of BF-227 was observed in the subjects with mild cognitive impairment who converted to AD during follow-up. DLB patients had elevated [11C]BF-227 uptake in the neocortex. However, FTD and sCJD patients showed no cortical retention of [11C]BF-227. Patients with multiple system atrophy had elevated BF-227 binding in the putamen. Finally, GSS patients had elevated BF-227 uptake in the cerebellum and other brain regions. This chapter confirms that BF-227 can selectively bind to a-synuclein and prion protein deposits using postmortem brain samples. Based on these findings, [11C]BF-227 is not necessarily specific for ß-amyloid in AD patients. However, this tracer could be used to detect various types of protein aggregates in the brain.

scholarly journals A Review of Neurotransmitters Sensing Methods for Neuro-Engineering Research

2019 ◽  
Vol 9 (21) ◽  
pp. 4719 ◽  
Author(s):  
Shimwe Dominique Niyonambaza ◽  
Praveen Kumar ◽  
Paul Xing ◽  
Jessy Mathault ◽  
Paul De Koninck ◽  
...  
Keyword(s):  
Imaging Techniques ◽  
Ongoing Research ◽  
Engineering Research ◽  
Detection Techniques ◽  
In Vivo Detection ◽  
Low Concentrations ◽  
The Subject ◽  
The Brain

Neurotransmitters as electrochemical signaling molecules are essential for proper brain function and their dysfunction is involved in several mental disorders. Therefore, the accurate detection and monitoring of these substances are crucial in brain studies. Neurotransmitters are present in the nervous system at very low concentrations, and they mixed with many other biochemical molecules and minerals, thus making their selective detection and measurement difficult. Although numerous techniques to do so have been proposed in the literature, neurotransmitter monitoring in the brain is still a challenge and the subject of ongoing research. This article reviews the current advances and trends in neurotransmitters detection techniques, including in vivo sampling and imaging techniques, electrochemical and nano-object sensing techniques for in vitro and in vivo detection, as well as spectrometric, analytical and derivatization-based methods mainly used for in vitro research. The document analyzes the strengths and weaknesses of each method, with the aim to offer selection guidelines for neuro-engineering research.

Oh, the places you’ll go!

2018 ◽  
Vol 10 (425) ◽  
pp. eaar7522
Author(s):  
Jennifer A. Philips
Keyword(s):  
Stem Cells ◽  
Amyloid Plaques ◽  
Selection Strategy ◽  
In Vivo Selection ◽  
Β Amyloid ◽  
The Brain

An in vivo selection strategy identifies an antibody that induces stem cells to differentiate into microglia-like cells, migrate to the brain, and reduce β-amyloid plaques in mice.

Recent advances in molecular imaging probes for β-amyloid plaques

MedChemComm ◽  
2015 ◽  
Vol 6 (3) ◽  
pp. 391-402 ◽  
Author(s):  
Masahiro Ono ◽  
Hideo Saji
Keyword(s):  
Molecular Imaging ◽  
Optical Imaging ◽  
Amyloid Plaques ◽  
Recent Advances ◽  
Molecular Imaging Probes ◽  
Imaging Probes ◽  
Β Amyloid ◽  
The Brain

We review recent advances in our development of molecular imaging probes for PET, SPECT, and optical imaging for in vivo detection of β-amyloid plaques in the brain.

In vivo detection of hepatitis C virus (HCV) RNA in the brain in a case of encephalitis: evidence for HCV neuroinvasion

2008 ◽  
Vol 15 (3) ◽  
pp. 214-218 ◽  
Author(s):  
F. Seifert ◽  
T. Struffert ◽  
M. Hildebrandt ◽  
I. Blümcke ◽  
W. Brück ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hcv Rna ◽  
In Vivo Detection ◽  
The Brain
Sign in / Sign up

Export Citation Format

Share Document