Cholesterol Efflux as a Critical Component of Alzheimer's Disease Pathogenesis

2004 ◽  
Vol 23 (3) ◽  
pp. 219-224 ◽  
Author(s):  
G. William Rebeck
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cholesterol Efflux ◽  
Critical Component ◽  
Disease Pathogenesis

scholarly journals Alzheimer’s Disease Pathogenesis: Role of Autophagy and Mitophagy Focusing in Microglia

2021 ◽  
Vol 22 (7) ◽  
pp. 3330
Author(s):  
Mehdi Eshraghi ◽  
Aida Adlimoghaddam ◽  
Amir Mahmoodzadeh ◽  
Farzaneh Sharifzad ◽  
Hamed Yasavoli-Sharahi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Therapeutic Target ◽  
Neurological Disorder ◽  
Inflammatory Cells ◽  
Disease Pathogenesis ◽  
Current Review ◽  
The Brain ◽  
Comprehensive Discussion

Alzheimer’s disease (AD) is a debilitating neurological disorder, and currently, there is no cure for it. Several pathologic alterations have been described in the brain of AD patients, but the ultimate causative mechanisms of AD are still elusive. The classic hallmarks of AD, including am-yloid plaques (Aβ) and tau tangles (tau), are the most studied features of AD. Unfortunately, all the efforts targeting these pathologies have failed to show the desired efficacy in AD patients so far. Neuroinflammation and impaired autophagy are two other main known pathologies in AD. It has been reported that these pathologies exist in AD brain long before the emergence of any clinical manifestation of AD. Microglia are the main inflammatory cells in the brain and are considered by many researchers as the next hope for finding a viable therapeutic target in AD. Interestingly, it appears that the autophagy and mitophagy are also changed in these cells in AD. Inside the cells, autophagy and inflammation interact in a bidirectional manner. In the current review, we briefly discussed an overview on autophagy and mitophagy in AD and then provided a comprehensive discussion on the role of these pathways in microglia and their involvement in AD pathogenesis.

scholarly journals Genetic Ablation of Apolipoprotein A-IV Accelerates Alzheimer's Disease Pathogenesis in a Mouse Model

2011 ◽  
Vol 178 (3) ◽  
pp. 1298-1308 ◽  
Author(s):  
Yujie Cui ◽  
Mingwei Huang ◽  
Yingbo He ◽  
Shuyan Zhang ◽  
Yongzhang Luo
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Disease Pathogenesis ◽  
Genetic Ablation ◽  
Apolipoprotein A

Impact of PLCG2 expression on Microglial Biology and Disease Pathogenesis in Alzheimer’s Disease

2021 ◽  
Vol 17 (S2) ◽  
Author(s):  
Andy Po‐Yi Tsai ◽  
Peter Bor‐Chian Lin ◽  
Chuanpeng Dong ◽  
Miguel Moutinho ◽  
Yunlong Liu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Pathogenesis

scholarly journals Causes versus effects: the increasing complexities of Alzheimer’s disease pathogenesis

2010 ◽  
Vol 10 (5) ◽  
pp. 683-691 ◽  
Author(s):  
Siddhartha Mondragón-Rodríguez ◽  
Gustavo Basurto-Islas ◽  
Hyoung-gon Lee ◽  
George Perry ◽  
Xiongwei Zhu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Pathogenesis

scholarly journals Long-Term Pantethine Treatment Counteracts Pathologic Gene Dysregulation and Decreases Alzheimer’s Disease Pathogenesis in a Transgenic Mouse Model

2019 ◽  
Vol 16 (4) ◽  
pp. 1237-1254 ◽  
Author(s):  
Kevin Baranger ◽  
Manuel van Gijsel-Bonnello ◽  
Delphine Stephan ◽  
Wassila Carpentier ◽  
Santiago Rivera ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Transgenic Mouse ◽  
Transgenic Mouse Model ◽  
Disease Pathogenesis ◽  
Gene Dysregulation

Neuroprotective effects of the amylin analogue pramlintide on Alzheimer's disease pathogenesis and cognition

2014 ◽  
Vol 35 (4) ◽  
pp. 793-801 ◽  
Author(s):  
Brittany L. Adler ◽  
Mark Yarchoan ◽  
Hae Min Hwang ◽  
Natalia Louneva ◽  
Jeffrey A. Blair ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Pathogenesis ◽  
Neuroprotective Effects
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