Changes in Regional Energy Metabolism after Cortical Cold Lesion in the Rat Brain

2002 ◽  
Vol 18 (3) ◽  
pp. 247-250 ◽  
Author(s):  
Martin R. Weinzier ◽  
Laurer Michael Fuchs ◽  
Wolf-Ingo Steudel ◽  
Angelica E.M. Mautes
Keyword(s):  
Energy Metabolism ◽  
Rat Brain ◽  
Cold Lesion ◽  
Regional Energy

Alterations in regional energy metabolism in rat brain produced by small and by large doses of apomorphine: possible relations to autoreceptors

1987 ◽  
Vol 139 (2) ◽  
pp. 139-146 ◽  
Author(s):  
Thomas Beck ◽  
Hans-Georg Möller ◽  
Klaus Nowak ◽  
Josef Krieglstein ◽  
Klaus Kuschinsky
Keyword(s):  
Energy Metabolism ◽  
Rat Brain ◽  
Regional Energy

Regional Energy Metabolism of Failing Hearts Following Myocardial Infarction

1993 ◽  
Vol 25 (9) ◽  
pp. 995-1013 ◽  
Author(s):  
Atsushi Sanbe ◽  
Kouichi Tanonaka ◽  
Yumiko Hanaoka ◽  
Takashi Katoh ◽  
Satoshi Takeo
Keyword(s):  
Myocardial Infarction ◽  
Energy Metabolism ◽  
Regional Energy

Stress-Resistant Neural Stem Cells Positively Influence Regional Energy Metabolism After Spinal Cord Injury in Mice

2011 ◽  
Vol 46 (2) ◽  
pp. 401-409 ◽  
Author(s):  
Karsten Schwerdtfeger ◽  
Angelika E. M. Mautes ◽  
Christian Bernreuther ◽  
Yifang Cui ◽  
Jérôme Manville ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Energy Metabolism ◽  
Neural Stem Cells ◽  
Regional Energy ◽  
Cord Injury

CARBOHYDRATE AND ENERGY METABOLISM IN PERINATAL RAT BRAIN: RELATION TO SURVIVAL IN ANOXIA

1975 ◽  
Vol 24 (2) ◽  
pp. 271-276 ◽  
Author(s):  
T. E. Duffy ◽  
S. J. Kohle ◽  
R. C. Vannucci
Keyword(s):  
Energy Metabolism ◽  
Rat Brain

scholarly journals Comparison of the Effects of Cyclosporin a on the Metabolism of Perfused Rat Brain Slices during Normoxia and Hypoxia

2002 ◽  
Vol 22 (3) ◽  
pp. 342-352 ◽  
Author(s):  
Natalie Serkova ◽  
Paul Donohoe ◽  
Sven Gottschalk ◽  
Carsten Hainz ◽  
Claus U. Niemann ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Cyclosporin A ◽  
Rat Brain ◽  
Ex Vivo ◽  
Brain Slices ◽  
High Energy ◽  
Metabolic Effects ◽  
Resonance Spectroscopy ◽  
Buffer Solution ◽  
Mitochondrial Energy Metabolism

The authors evaluated and compared the metabolic effects of cyclosporin A in the rat brain during normoxia and hypoxia/reperfusion. Ex vivo31P magnetic resonance spectroscopy experiments based on perfused rat brain slices showed that under normoxic conditions, 500 μg/L cyclosporin A significantly reduced mitochondrial energy metabolism (nucleotide triphosphate, 83 ± 9% of controls; phosphocreatine, 69 ± 9%) by inhibition of the Krebs cycle (glutamate, 77 ± 5%) and oxidative phosphorylation (NAD+, 65 ± 14%) associated with an increased generation of reactive oxygen species (285 ± 78% of control). However, the same cyclosporin A concentration (500 μg/L) was found to be the most efficient concentration to inhibit the hypoxia-induced mitochondrial release of Ca2+ in primary rat hippocampal cells with cytosolic Ca2+ concentrations not significantly different from normoxic controls. Addition of 500 μg/L cyclosporin A to the perfusion medium protected high-energy phosphate metabolism (nucleotide triphosphate, 11 ± 15% of control vs. 35 ± 9% with 500 μg/L cyclosporin A) and the intracellular pH (6.2 ± 0.1 control vs. 6.6 ± 0.1 with cyclosporin A) in rat brain slices during 30 minutes of hypoxia. Results indicate that cyclosporin A simultaneously decreases and protects cell glucose and energy metabolism. Whether the overall effect was a reduction or protection of cell energy metabolism depended on the concentrations of both oxygen and cyclosporin A in the buffer solution.

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