Dysregulation of Cellular Calcium Homeostasis in Alzheimer's Disease: Bad Genes and Bad Habits

2001 ◽  
Vol 17 (2) ◽  
pp. 205-224 ◽  
Author(s):  
Mark P. Mattson ◽  
Sic L. Chan
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Calcium Homeostasis ◽  
Cellular Calcium

O4-06-06: The calcium homeostasis modulator CALHM1 controls Abeta levels and Alzheimer's disease risk

2008 ◽  
Vol 4 ◽  
pp. T197-T197
Author(s):  
Philippe Marambaud ◽  
Ute Dreses-Werringloer ◽  
Jean-Charles Lambert ◽  
Valérie Vingtdeux ◽  
Haitian Zhao ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Calcium Homeostasis ◽  
Disease Risk

Lymphocytes and neutrophils as peripheral models to study the effect of β-amyloid on cellular calcium signalling in Alzheimer's disease

Life Sciences ◽  
1996 ◽  
Vol 59 (5-6) ◽  
pp. 499-510 ◽  
Author(s):  
Anne Eckert ◽  
Hans Förstl ◽  
Rainer Zerfass ◽  
Henrike Hartmann ◽  
Walter E. Müller
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Calcium Signalling ◽  
Cellular Calcium ◽  
Β Amyloid

scholarly journals Familial Alzheimer’s disease–associated presenilin-1 alters cerebellar activity and calcium homeostasis

2014 ◽  
Vol 124 (4) ◽  
pp. 1552-1567 ◽  
Author(s):  
Diego Sepulveda-Falla ◽  
Alvaro Barrera-Ocampo ◽  
Christian Hagel ◽  
Anne Korwitz ◽  
Maria Fernanda Vinueza-Veloz ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Calcium Homeostasis ◽  
Presenilin 1 ◽  
Familial Alzheimer’S Disease ◽  
Familial Alzheimer's Disease

Mitochondrial calcium uniporter as a potential therapeutic strategy for Alzheimer’s disease

2019 ◽  
Vol 32 (2) ◽  
pp. 65-71 ◽  
Author(s):  
Anila Venugopal ◽  
Mahalaxmi Iyer ◽  
Venkatesh Balasubramanian ◽  
Balachandar Vellingiri
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mitochondrial Dysfunction ◽  
Calcium Homeostasis ◽  
Therapeutic Strategy ◽  
Neurodegenerative Disorder ◽  
Amyloid Plaque ◽  
Mitochondrial Calcium ◽  
Mitochondrial Calcium Uniporter ◽  
Calcium Uniporter

AbstractAlzheimer’s disease (AD), a neurodegenerative disorder, is the leading cause of dementia in the world whose aetiology is still unclear. AD was always related to ageing though there have been instances where people at an early age also succumb to this disease. With medical advancements, the mortality rate has significantly reduced which also makes people more prone to AD. AD is rare, yet the prominent disease has been widely studied with several hypotheses trying to understand the workings of its onset. The most recent and popular hypothesis in AD is the involvement of mitochondrial dysfunction and calcium homeostasis in the development of the disease though their exact roles are not known. With the sudden advent of the mitochondrial calcium uniporter (MCU), many previously known pathological hallmarks of AD may be better understood. Several studies have shown the effect of excess calcium in mitochondria and the influence of MCU complex in mitochondrial function. In this article, we discuss the possible involvement of MCU in AD by linking the uniporter to mitochondrial dysfunction, calcium homeostasis, reactive oxygen species, neurotransmitters and the hallmarks of AD – amyloid plaque formation and tau tangle formation.

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