Calvarial Doughnut Lesions Associated with High-Turnover Osteoporosis Presenting in Childhood

1999 ◽  
Vol 2 (1) ◽  
pp. 45-53 ◽  
Author(s):  
John L. Stock ◽  
James A. Coderre ◽  
Judith H. Overdorf ◽  
Lorraine A. Fitzpatrick ◽  
Jay R. Shapiro
Keyword(s):  
High Turnover ◽  
High Turnover Osteoporosis

scholarly journals Gastric Inhibitory Polypeptide as an Endogenous Factor Promoting New Bone Formation after Food Ingestion

2006 ◽  
Vol 20 (7) ◽  
pp. 1644-1651 ◽  
Author(s):  
Katsushi Tsukiyama ◽  
Yuichiro Yamada ◽  
Chizumi Yamada ◽  
Norio Harada ◽  
Yukiko Kawasaki ◽  
...  
Keyword(s):  
Bone Formation ◽  
Intracellular Signaling ◽  
Gastric Inhibitory Polypeptide ◽  
Calcium Deposition ◽  
High Turnover ◽  
Blood Calcium ◽  
Gut Hormone ◽  
High Turnover Osteoporosis ◽  
Meal Ingestion

Abstract Calcium plays a fundamental role as second messenger in intracellular signaling and bone serves as the body’s calcium reserve to tightly maintain blood calcium levels. Calcium in ingested meal is the main supply and inadequate calcium intake causes osteoporosis and bone fracture. Here, we describe a novel mechanism of how ingested calcium is deposited on bone. Meal ingestion elicits secretion of the gut hormone gastric inhibitory polypeptide (GIP) from endocrine K cells in the duodenum. Bone histomorphometrical analyses revealed that bone formation parameters in the mice lacking GIP receptor (GIPR−/−) were significantly lower than those of wild-type (GIPR+/+) mice, and that the number of osteoclasts, especially multinuclear osteoclasts, was significantly increased in GIPR−/− mice, indicating that GIPR−/− mice have high-turnover osteoporosis. In vitro examination showed the percentage of osteoblastic cells undergoing apoptosis to be significantly decreased in the presence of GIP. Because GIPR−/− mice exhibited an increased plasma calcium concentration after meal ingestion, GIP directly links calcium contained in meal to calcium deposition on bone.

Effect of exercise on the development of osteoporosis in adult rats

1989 ◽  
Vol 66 (1) ◽  
pp. 14-19 ◽  
Author(s):  
K. H. Myburgh ◽  
T. D. Noakes ◽  
M. Roodt ◽  
F. S. Hough
Keyword(s):  
Breaking Strength ◽  
Bone Volume ◽  
Moderate Exercise ◽  
High Turnover ◽  
Urinary Hydroxyproline ◽  
Adult Rats ◽  
Normal Bone ◽  
High Turnover Osteoporosis ◽  
Long Evans

The role of moderate exercise in the prevention of high-turnover osteoporosis was investigated by the use of an animal model. The effect of chronic training on gravimetric, mineral, physical, and histological parameters of normal bone was also examined. Fifty-six adult female Long-Evans rats were divided into four groups: sedentary (C) and exercising controls (E) and sedentary (O) and exercising osteoporotics (EO). Exercising animals ran 4 h/wk for 1 yr. Two percent NH4Cl added to drinking water induced osteoporosis as shown by significantly lower femoral density and breaking strength and histomorphometrically quantified tibial trabecular bone volume but a normal mineral-to-matrix ratio in the O rats. The development of high-turnover osteoporosis in O rats was confirmed by significantly higher alkaline phosphatase activity (P less than 0.05), urinary hydroxyproline content (P less than 0.01), resorption surfaces (P less than 0.01), and histological parameters of bone formation (P less than 0.01). Exercise prevented all these biochemical, biophysical, and histological abnormalities in the EO group. Exercise had no influence on the density of normal femurs but tended to increase their breaking strength (by 11%) compared with femurs of C rats (P = 0.11).

Rapamycin improves bone mass in high-turnover osteoporosis with iron accumulation through positive effects on osteogenesis and angiogenesis

Bone ◽  
2019 ◽  
Vol 121 ◽  
pp. 16-28 ◽  
Author(s):  
Jiadong Wu ◽  
Aifei Wang ◽  
Xiao Wang ◽  
Guangfei Li ◽  
Peng Jia ◽  
...  
Keyword(s):  
Bone Mass ◽  
Iron Accumulation ◽  
High Turnover ◽  
Positive Effects ◽  
High Turnover Osteoporosis

Suppressed Bone Turnover during Alendronate Therapy for High-Turnover Osteoporosis

2006 ◽  
Vol 355 (19) ◽  
pp. 2048-2050 ◽  
Author(s):  
Reina Armamento-Villareal ◽  
Nicola Napoli ◽  
Vinita Panwar ◽  
Deborah Novack
Keyword(s):  
Bone Turnover ◽  
High Turnover ◽  
High Turnover Osteoporosis

Bone Matrix, Cellularity, and Structural Changes in a Rat Model with High-Turnover Osteoporosis Induced by Combined Ovariectomy and a Multiple-Deficient Diet

2014 ◽  
Vol 184 (3) ◽  
pp. 765-777 ◽  
Author(s):  
Parameswari Govindarajan ◽  
Wolfgang Böcker ◽  
Thaqif El Khassawna ◽  
Marian Kampschulte ◽  
Gudrun Schlewitz ◽  
...  
Keyword(s):  
Rat Model ◽  
Structural Changes ◽  
Bone Matrix ◽  
High Turnover ◽  
Deficient Diet ◽  
High Turnover Osteoporosis
Sign in / Sign up

Export Citation Format

Share Document