Cytotoxic T-Lymphocyte Antigen-4 and Programmed Death-1 Function as Negative Regulators of Lymphocyte Activation

2003 ◽  
Vol 28 (1) ◽  
pp. 49-60 ◽  
Author(s):  
Laura L. Carter ◽  
Beatriz M. Carreno
Keyword(s):  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Lymphocyte Activation ◽  
Negative Regulators ◽  
Lymphocyte Antigen ◽  
Programmed Death ◽  
Programmed Death 1

Interactions between programmed death 1 (PD-1) and cytotoxic T lymphocyte antigen 4 (CTLA-4) gene polymorphisms in type 1 diabetes

2009 ◽  
Vol 83 (3) ◽  
pp. 289-294 ◽  
Author(s):  
Scherezade Momin ◽  
Sylvia Flores ◽  
Bárbara Angel B ◽  
Ethel Codner D ◽  
Elena Carrasco P ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Lymphocyte ◽  
Gene Polymorphisms ◽  
Cytotoxic T Lymphocyte ◽  
Lymphocyte Antigen ◽  
Programmed Death ◽  
Programmed Death 1

scholarly journals Cytotoxic T-Lymphocyte-Associated Antigen 4 (CTLA-4)- and Programmed Death 1 (PD-1)-Mediated Regulation of Monofunctional and Dual Functional CD4+ and CD8+ T-Cell Responses in a Chronic Helminth Infection

2019 ◽  
Vol 87 (12) ◽  
Author(s):  
Anuradha Rajamanickam ◽  
Saravanan Munisankar ◽  
Chandrakumar Dolla ◽  
Thomas B. Nutman ◽  
Subash Babu
Keyword(s):  
T Cell ◽  
T Lymphocyte ◽  
Helminth Infection ◽  
Cytotoxic T Lymphocyte ◽  
T Cell Responses ◽  
Content Type ◽  
Cell Responses ◽  
Dual Functional ◽  
Programmed Death ◽  
Programmed Death 1

ABSTRACT Chronic helminth infections are known to be associated with the modulation of antigen-specific T-cell responses. Strongyloides stercoralis infection is characterized by the downmodulation of antigen-specific Th1 and Th17 responses and the upregulation of Th2 and Th9 responses. Immune homeostasis is partially maintained by negative regulators of T-cell activation, cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1), which dampen effector responses during chronic infections. However, their roles in S. stercoralis infection are yet to be defined. Therefore, we sought to determine the role of CTLA-4 and PD-1 in regulating CD4+ and CD8+ T-cell responses and examined the frequencies of monofunctional and dual functional Th1/T cytotoxic type 1 (Tc1), Th17/Tc17, Th2/Tc2, and Th9/Tc9 cells in S. stercoralis infection in 15 infected individuals stimulated with parasite antigen following CTLA-4 or PD-1 blockade. Our data reveal that CTLA-4 or PD-1 blockade results in significantly enhanced frequencies of monofunctional and dual functional Th1/Tc1 and Th17/Tc17 cells and, in contrast, diminishes the frequencies of monofunctional and dual functional Th2/Tc2 and Th9/Tc9 cells with parasite antigen stimulation in whole-blood cultures. Thus, we demonstrate that CTLA-4 and PD-1 limit the induction of particular T-cell subsets in S. stercoralis infection, which suggests the importance of CTLA-4 and PD-1 in immune modulation in a chronic helminth infection.

scholarly journals Immune checkpoints programmed death 1 ligand 1 and cytotoxic T lymphocyte associated molecule 4 in gastric adenocarcinoma

2015 ◽  
Vol 5 (5) ◽  
pp. e1100789 ◽  
Author(s):  
Hans A. Schlößer ◽  
Uta Drebber ◽  
Michael Kloth ◽  
Martin Thelen ◽  
Sacha I. Rothschild ◽  
...  
Keyword(s):  
Gastric Adenocarcinoma ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Immune Checkpoints ◽  
Programmed Death ◽  
Programmed Death 1
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