Mechanisms of Signal Transduction Activated by Sublytic Assembly of Terminal Complement Complexes on Nucleated Cells

2001 ◽  
Vol 24 (2) ◽  
pp. 191-200 ◽  
Author(s):  
Florin Niculescu ◽  
Horea Rus
Keyword(s):  
Signal Transduction ◽  
Terminal Complement Complexes ◽  
Terminal Complement

Histologic Localization of Terminal Complement Complexes in Renal Diseases: An Immunohistochemical Study

1989 ◽  
Vol 91 (2) ◽  
pp. 144-151 ◽  
Author(s):  
Tetsuya Ootaka ◽  
Masahiko Suzuki ◽  
Katsuhiko Sudo ◽  
Hiroshi Sato ◽  
Jin Seino ◽  
...  
Keyword(s):  
Immunohistochemical Study ◽  
Renal Diseases ◽  
Terminal Complement Complexes ◽  
Terminal Complement

COMP-C3b Complexes in Rheumatoid Arthritis with Severe Extraarticular Manifestations

2013 ◽  
Vol 40 (12) ◽  
pp. 2001-2005 ◽  
Author(s):  
Kaisa E. Happonen ◽  
Tore Saxne ◽  
Lennart Jacobsson ◽  
Gunnar Sturfelt ◽  
Johan Rönnelid ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Cartilage Oligomeric Matrix Protein ◽  
Matrix Protein ◽  
Healthy Controls ◽  
Terminal Complement Complexes ◽  
Terminal Complement ◽  
Extraarticular Manifestations

Objective.To investigate biomarker patterns in rheumatoid arthritis (RA) with extraarticular manifestations.Methods.Cartilage oligomeric matrix protein (COMP), COMP-C3b, and soluble terminal complement complexes (sTCC) were measured by ELISA.Results.COMP-C3b levels were higher in patients with RA than in healthy controls and lower in extraarticular RA (ExRA) than in RA controls. In patients with ExRA, sTCC levels were higher than in RA controls, and correlated inversely with serum COMP-C3b levels in the ExRA group.Conclusion.Patients with ExRA had lower levels of COMP-C3b. This may be a consequence of complement consumption or a lower potential for COMP from these patients to activate complement.

Release of Neopterin, PMN Elastase and Terminal Complement Complexes by Orthotopic Liver Transplantation with and without the Use of Veno-venous Bypass

Pteridines ◽  
1998 ◽  
Vol 9 (1) ◽  
pp. 1-7
Author(s):  
H. Tomasdottir ◽  
E. Rønholm ◽  
JP Bengtson ◽  
A. Bengtsson
Keyword(s):  
Liver Transplantation ◽  
Orthotopic Liver Transplantation ◽  
Plasma Concentrations ◽  
Venous Bypass ◽  
Pmn Elastase ◽  
Arterial Blood ◽  
Neopterin Concentration ◽  
Pmn Élastase ◽  
Terminal Complement Complexes ◽  
Terminal Complement

Summary Aim: The aim of the study was to determine whether orthotopic liver transplantation leads to the activation of macrophages, neutrophils and complement. Patients and methods: Twenty-four patients undergoing orthotopic liver transplantation were studied. 12 were operated on with and 12 without the use of a veno-venous bypass. Blood samples for neopterin, PMN elastase and terminal complement complex (SC5b-9) determinations were drawn preoperatively, 1 minute before perfusion of the grafted liver and 2-5 and 30-60 minutes after the start of perfusion of the grafted liver. Comparisons were made between patients with or withour a veno-venous bypass and with or without postreperfusion syndrome (PRS) . PRS was defined as hypotension with ≥30% reduction of systemic mean arterial blood pressure during at least 1 minute after reperfusion of the grafted liver. Results: Release of neopterin was observed 2-5 and 30-60 minutes after the start of perfusion of the grafted liver in patients operated upon with and without the use of a veno-venous bypass. There were no significant differences in neopterin concentration between patients developing PRS and those without circulatory instability. Increased PMN elastase and SC5b-9 concentrations (p<0.05) were found 2-5 and 30-60 minutes after the start of reperfusion in both patients operated upon with and without a veno-venous bypass. The plasma concentrations of neopterin, PMN elastase and SC5b-9 were higher in patients with PRS compared with those without (p<0.05, respectively). Comments: This study indicates that orthotopic liver transplantation leads to the activation of macrophages, neutrophils and the complement cascade. There is no major difference regarding the activation between patients operated upon with and without the use of a veno-venous bypass.

Generation of Terminal Complement Complexes in Psoriatic Lesional Skin

Dermatology ◽  
1992 ◽  
Vol 185 (4) ◽  
pp. 246-250 ◽  
Author(s):  
H. Takematsu ◽  
H. Tagami
Keyword(s):  
Lesional Skin ◽  
Terminal Complement Complexes ◽  
Terminal Complement

scholarly journals Membrane attack by complement: the assembly and biology of terminal complement complexes

2011 ◽  
Vol 51 (1) ◽  
Author(s):  
Cosmin A. Tegla ◽  
Cornelia Cudrici ◽  
Snehal Patel ◽  
Richard Trippe ◽  
Violeta Rus ◽  
...  
Keyword(s):  
Terminal Complement Complexes ◽  
Terminal Complement
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