The Preventive Effect of Ketoconazole on Experimental Metastasis from a Human Pancreatic Carcinoma may be Related to its Effect on Prostaglandin Synthesis

2002 ◽  
Vol 32 (1) ◽  
pp. 23-30 ◽  
Author(s):  
George N. Tzanakakis ◽  
Elias Krambovitis ◽  
Aristidis M. Tsatsakis ◽  
Michael P. Vezeridis
Keyword(s):  
Pancreatic Carcinoma ◽  
Prostaglandin Synthesis ◽  
Experimental Metastasis ◽  
Preventive Effect

Immunotherapy of pancreatic carcinoma with siRNA targeting TGF-beta

2009 ◽  
Vol 47 (10) ◽  
Author(s):  
J Ellermeier ◽  
J Wie ◽  
P Düwell ◽  
S Endres ◽  
M Schnurr
Keyword(s):  
Pancreatic Carcinoma ◽  
Tgf Beta

Ten new primary pancreatic carcinoma cell lines

2011 ◽  
Vol 49 (08) ◽  
Author(s):  
F Rückert ◽  
D Aust ◽  
S Hering ◽  
K Werner ◽  
HD Saeger ◽  
...  
Keyword(s):  
Pancreatic Carcinoma ◽  
Cell Lines ◽  
Carcinoma Cell ◽  
Carcinoma Cell Lines

The Action Mechanism of the Purified Platelet Aggregation Principle of Trimeresurus mucrosquamatus Venom

1979 ◽  
Vol 41 (03) ◽  
pp. 475-490 ◽  
Author(s):  
Chaoho Ouyang ◽  
Che-Ming Teng
Keyword(s):  
Platelet Aggregation ◽  
Adenine Nucleotides ◽  
Muscle Relaxants ◽  
Prostaglandin Synthesis ◽  
Action Mechanism ◽  
Crude Venom ◽  
Platelet Factor ◽  
Induce Platelet Aggregation ◽  
Minimal Concentration ◽  
Aggregation Principle

SummaryThe minimal concentration of the platelet aggregation principle (Platelet Aggregoserpen- tin, PAS) necessary to induce platelet aggregation was 10 ng/ml, about one-hundredth of that of the crude venom. PAS induced the release of platelet factors 3 and 4 from platelets, but the released platelet factor 3 was easily inactivated by the anti-phospholipid effect of PAS. Pretreatment of platelets with neuraminidase potentiated PAS-induced platelet aggregation. PAS-induced platelet aggregation was independent on released ADP; it could occur in the ADP-removing systems, such as apyrase or a combination of phosphoenolpyruvate and pyruvate kinase. However, PAS-induced platelet aggregation could be inhibited by adenine nucleotides and adenosine.PAS-induced platelet aggregation was inhibited by some anti-inflammatory agents, antimalarial drugs, local anesthetics, antihistamine and smooth muscle relaxants. After deaggregation of PAS-treated platelets, thrombin and sodium arachidonate could further induce platelet aggregation, but ADP and second dose of PAS could not. It is concluded that PAS-induced platelet aggregation is due to prostaglandin synthesis. Recent literatures on the mechanism of platelet aggregation were surveyed and the actions of PAS were discussed.

Oxytocin-producing pancreatic carcinoma presenting as ectopic ACTH syndrome

1989 ◽  
Vol 120 (3_Suppl) ◽  
pp. S17-S18
Author(s):  
W. A. SCHERBAUM ◽  
G. JIRIKOWSKI ◽  
E. F. PFEIFFER
Keyword(s):  
Pancreatic Carcinoma ◽  
Ectopic Acth Syndrome ◽  
Ectopic Acth
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