BRAF Mutation Is Unusual in Chronic Lymphocytic Thyroiditis-Associated Papillary Thyroid Carcinomas and Absent in Non-Neoplastic Nuclear Atypia of Thyroiditis

2006 ◽  
Vol 17 (3) ◽  
pp. 235-242 ◽  
Author(s):  
Rachel Sargent ◽  
Virginia LiVolsi ◽  
Justin Murphy ◽  
Geeta Mantha ◽  
Jennifer L. Hunt
Keyword(s):  
Braf Mutation ◽  
Chronic Lymphocytic Thyroiditis ◽  
Papillary Thyroid ◽  
Lymphocytic Thyroiditis ◽  
Thyroid Carcinomas ◽  
Nuclear Atypia

Both gender and concurrent chronic lymphocytic thyroiditis may influence the nuclear texture of papillary thyroid carcinomas cells

2014 ◽  
Vol 39 (3) ◽  
pp. 126-129
Author(s):  
Lucas Leite Cunha ◽  
Rita de Cássia Ferreira ◽  
Patricia Sabino de Matos ◽  
Ligia Vera Montalli da Assumpção ◽  
Laura Sterian Ward
Keyword(s):  
Chronic Lymphocytic Thyroiditis ◽  
Papillary Thyroid ◽  
Lymphocytic Thyroiditis ◽  
Thyroid Carcinomas ◽  
Nuclear Texture

scholarly journals Chronic lymphocytic thyroiditis and BRAF V600E in papillary thyroid carcinoma

2015 ◽  
Vol 23 (1) ◽  
pp. 27-34 ◽  
Author(s):  
Seo Ki Kim ◽  
Jung-Woo Woo ◽  
Jun Ho Lee ◽  
Inhye Park ◽  
Jun-Ho Choe ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Clinical Significance ◽  
Braf Mutation ◽  
Independent Predictor ◽  
Chronic Lymphocytic Thyroiditis ◽  
Papillary Thyroid ◽  
Mutation Status ◽  
Lymphocytic Thyroiditis ◽  
Low Prevalence

It has been reported that papillary thyroid carcinoma (PTC) with chronic lymphocytic thyroiditis (CLT) is less associated with extrathyroidal extension (ETE), advanced tumor stage and lymph node (LN) metastasis. Other studies have suggested that concurrent CLT could antagonize PTC progression, even in BRAF-positive patients. Since the clinical significance of the BRAF mutation has been particularly associated with conventional PTC, the purpose of this study was to determine the clinical significance of CLT according to BRAF mutation status in conventional PTC patients. We retrospectively reviewed the medical records of 3332 conventional PTC patients who underwent total thyroidectomy with bilateral central neck dissection at the Thyroid Cancer Center of Samsung Medical Center between January 2008 and June 2015. In this study, the prevalence of BRAF mutation was significantly less frequent in conventional PTC patients with CLT (76.9% vs 86.6%). CLT was an independent predictor for low prevalence of ETE in both BRAF-negative (OR=0.662, P=0.023) and BRAF-positive (OR=0.817, P=0.027) conventional PTC patients. In addition, CLT was an independent predictor for low prevalence of CLNM in both BRAF-negative (OR=0.675, P=0.044) and BRAF-positive (OR=0.817, P=0.030) conventional PTC patients. In conclusion, BRAF mutation was significantly less frequent in conventional PTC patients with CLT. However, CLT was an independent predictor for less aggressiveness in conventional PTC patients regardless of BRAF mutation status.

scholarly journals Identifying Risk Factors for a High Lymph Node Ratio (over 0.8) in Papillary Thyroid Carcinoma Patients

2020 ◽  
Author(s):  
Yuewu Liu ◽  
LY Zhang ◽  
xiaoyi li ◽  
hongfeng liu
Keyword(s):  
Risk Factors ◽  
Lymph Node ◽  
Lymph Node Ratio ◽  
Male Gender ◽  
Chronic Lymphocytic Thyroiditis ◽  
Papillary Thyroid ◽  
Central Lymph Node ◽  
Lymphocytic Thyroiditis ◽  
Node Ratio ◽  
Central Lymph

Abstract Background Despite the majority of papillary thyroid carcinoma (PTC) patients has an excellent prognosis, central lymph node metastases (CLNM) are common. The relationship between CLNM and prognosis is still controversial, however, a certain lymph node ratio (LNR) has been reported to show significantly worse prognosis for PTC patients. Therefore, the extent of CLNM seems to play an important role in predicting the recurrence and survival of PTC. The aim of this study is to determine the risk factors for a high LNR (over 0.8) in central compartment in PTC patients. Methods A retrospective cohort study was conducted on PTC patients who underwent total thyroidectomy or lobectomy plus central lymph node dissection (CLND) between January 2011 and December 2015. Patients with an LNR over 0.8 was defined as Group A, and patients with an LNR 0 was defined as group B. The clinical and pathological factors such as gender, age, tumor size, tumor number, extracapsular spread (ECS), MACIS score, and co-existence of chronic lymphocytic thyroiditis （CLT）were compared between different LNR groups.Results Univariate analysis found high LNR to be associated with male gender, young age(<40 years) ,larger tumor (≥1 cm), ECS and absence of chronic lymphocytic thyroiditis. Multivariate logistic regression showed male gender (p = 0.007, OR = 3.79), young age(<40 years) (p = 0.000, OR = 0.159), larger tumor (≥1 cm) (p =0.033, OR = 2.530), and absence of chronic lymphocytic thyroiditis (p = 0.036, OR = 0.321) to be independent predictors for high LNR in PTC patients Conclusions Male gender, younger age (<40 years), larger tumor (≥1 cm) and absence of chronic lymphocytic thyroiditis were risk factors of high LNR. We recommend a prophylactic CLND should be considered in PTC patients with such risk factors.

Quality Control and Telemedicine for BRAF V600E Mutations in Papillary Thyroid Carcinomas

2015 ◽  
Vol 4 (2) ◽  
pp. 12-30 ◽  
Author(s):  
Niki Margari ◽  
Abraham Pouliakis ◽  
Aris Spathis ◽  
Emmanouil Mastorakis ◽  
Efthymios Karakostas ◽  
...  
Keyword(s):  
Quality Control ◽  
Braf Mutation ◽  
Image Features ◽  
Classification And Regression Tree ◽  
Braf V600e ◽  
Papillary Thyroid ◽  
Cell Nuclei ◽  
Braf Mutations ◽  
Mutation Status ◽  
Thyroid Carcinomas

The assessment of BRAF V600E mutations is important for prognosis and treatment of Papillary Thyroid Carcinomas (PTC), the standard methods for their identification are molecular biology techniques. In this study, the potential of image morphometry applied to cell nuclei and sequentially the use of a Classification And Regression Tree (CART) is investigated, in order to: identify morphometric features useful to characterize BRAF mutations, and to eventually produce an algorithm identifying BRAF mutation status. The 140 studied cases had histological confirmation and known BRAF mutation status identified via real-time PCR. The analysis revealed that nuclear features contributing to BRAF mutation status identification via the CART model are related mostly to nuclear color. According to the results there is evidence that BRAF V600E mutations can be identified by measurable image features. Therefore, the proposed method is useful for quality control of BRAF V600E mutations on cytological slides, can serve as alternative to PCR method and may be used for remote assessment.

Reduced expression of THRβ in papillary thyroid carcinomas: relationship with BRAF mutation, aggressiveness and miR expression

2015 ◽  
Vol 38 (12) ◽  
pp. 1283-1289 ◽  
Author(s):  
F. Rosignolo ◽  
V. Maggisano ◽  
M. Sponziello ◽  
M. Celano ◽  
C. R. T. Di Gioia ◽  
...  
Keyword(s):  
Braf Mutation ◽  
Papillary Thyroid ◽  
Thyroid Carcinomas

scholarly journals Chronic lymphocytic thyroiditis (CLT) has a negative prognostic value in papillary thyroid cancer of the young and middle ages: a retrospective analysis of 635 patients

2020 ◽  
Author(s):  
Bing'e Ma ◽  
Xiyi Chen ◽  
Zhengping Zhao ◽  
Qin Ji ◽  
Yifan Zhou ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
High Risk ◽  
Prognostic Value ◽  
Age Groups ◽  
Recurrence Risk ◽  
Lesion Size ◽  
Chronic Lymphocytic Thyroiditis ◽  
Papillary Thyroid ◽  
Lymphocytic Thyroiditis ◽  
Risk Recurrence

Abstract Background: The study was aimed at investigating the potential role of chronic lymphocytic thyroiditis (CLT) in papillary thyroid cancer (PTC) prognosis in distinct age groups, as well as the association between CLT and recurrence risk estimation.Methods: A total of 635 adult patients were retrospectively analyzed. On the basis of postoperative pathology examination, 188 patients were diagnosed with coexistent CLT and the remaining 447 were classified as non-CLT. Then the characteristics of CLT-coexisted patients and non-CLT ones were compared respectively when patients were aged ≥55 years or below. The association among postoperative clinicopathological features were also analyzed using multivariate regression. In addition, the prognostic value of several variables relating to high-risk recurrence were estimated within different age groups.Results: When divided in two age groups (55 years as the line), non-CLT group had a remarkable frequency of small size lesion (D max ≤1cm) compared with CLT-coexisted patients (54.6% to 43.0%, p =0.016). In addition, non-CLT patients tended to have intrathyroidal extension as opposed to those with coexistent CLT (20.2% to 28.2%, p =0.05). In multivariate analysis, CLT still significantly acted as an independent risk factor of greater lesion size (D min >1 cm) (OR=1.7, p =0.02) and mildly promoted gross extrathyroidal extension (ETE) (OR=1.4, p =0.06). However, associations didn't emerge in the characteristics mentioned above with CLT when patients were ≥55 years old. The prognostic value of CLT in high-risk recurrence was evident only in patients aged 35-44 years. (OR=2.4, 95%CI:1.2-5.4, p =0.02). Greater lesion size independently promoted gross ETE, no matter patients were aged above 55 years or not. Besides, its prognostic value of high-risk recurrence was significant throughout all age groups. Conclusion: These findings revealed that CLT coexistence might be the unfavorable factor of PTC prognosis in young and middle-aged (<55 years) patients, and its role in recurrence risk stratification was presented only in the specific age (35-44 years).

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