Double Adenomas of the Pituitary: Transcription Factors Pit-1, T-pit, and SF-1 Identify Cytogenesis and Differentiation

2005 ◽  
Vol 16 (3) ◽  
pp. 187-194 ◽  
Author(s):  
R. A. Jastania ◽  
K. O. Alsaad ◽  
M. Al-Shraim ◽  
K. Kovacs ◽  
S. L. Asa
Keyword(s):  
Transcription Factors ◽  
Pituitary Transcription Factors ◽  
Double Adenomas

Two Cases of Double Adenomas in a Surgical Series over 16 Years in a Single Centre

2021 ◽  
Vol 21 ◽  
Author(s):  
Luca Damiani ◽  
Luca Riccioni ◽  
Daniele Nuzzi ◽  
Mariella Celico ◽  
Riccardo Panzacchi ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Retrospective Analysis ◽  
Pituitary Adenomas ◽  
Clinical Presentation ◽  
Histopathological Examination ◽  
Single Center ◽  
Single Centre ◽  
Pituitary Transcription Factors ◽  
Double Pituitary Adenomas ◽  
Double Adenomas

Background: Double pituitary adenomas (DA) are two morphologically and immunohystochemically different tumours in the same gland. They are rare, generally small adenomas and divided in: separated, when clearly recognizable before or during surgery, and contiguous, when diagnosed only in the following histopathological examination. Acromegaly and Cushing’s disease are the main prevalent clinical presentation. Objective: We described two cases of DA in a surgical series over 16 years in a single center. Methods: In September 2018 we diagnosed a DA in a man with acromegaly (case 1). In order to assess the presence of other cases of DA, we performed a retrospective analysis of the endonasal endoscopically operated sellar adenomas from January 2004 to December 2019. Results : 468 pituitary adenomas were found. A DA with a Pit-1 positive small macroadenoma (GH-TSH- PRL positive) and an ACTH microadenoma clinically silent in an acromegalic woman was retrospectively found (case 2). Conclusion : Our analysis confirms that DA are rare (0.4 % of the pituitary adenomas) and often associated with acromegaly. Their pre-operatively diagnosis is difficult but clinician’s awareness of DA can improve the diagnosis. The use of pituitary transcription factors could be useful in detecting DA.

Pituitary Transcription Factors and ß-CateninGene Mutations in Adamantinomatous Craniopharyngiomas.

2010 ◽  
pp. P1-239-P1-239
Author(s):  
ML Campanini ◽  
SR Antonini ◽  
FC Amaral ◽  
HR Machado ◽  
AC Moreira ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Pituitary Transcription Factors

Transcriptional regulation of the chicken CRHR2 gene by pituitary transcription factors

2019 ◽  
Vol 284 ◽  
pp. 113263
Author(s):  
Ellyse B. Noy ◽  
Yugo Watanabe ◽  
Sylvia V.H. Grommen ◽  
Bert De Groef
Keyword(s):  
Transcriptional Regulation ◽  
Transcription Factors ◽  
Pituitary Transcription Factors

scholarly journals CTNNB1 Gene Mutations, Pituitary Transcription Factors, and MicroRNA Expression Involvement in the Pathogenesis of Adamantinomatous Craniopharyngiomas

2010 ◽  
Vol 1 (4) ◽  
pp. 187-196 ◽  
Author(s):  
Marina Lanciotti Campanini ◽  
Leandro Machado Colli ◽  
Beatriz Maria Carvalho Paixao ◽  
Tatiana Pereira Freitas Cabral ◽  
Fernando Colbari Amaral ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Gene Mutations ◽  
Microrna Expression ◽  
Ctnnb1 Gene ◽  
Pituitary Transcription Factors

scholarly journals Double adenomas of the pituitary reveal distinct lineage markers, copy number alterations, and epigenetic profiles

Pituitary ◽  
2021 ◽  
Author(s):  
Christian Hagel ◽  
Ulrich Schüller ◽  
Jörg Flitsch ◽  
Ulrich J. Knappe ◽  
Udo Kellner ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Copy Number ◽  
Pituitary Hormone ◽  
Null Cell ◽  
Global Methylation ◽  
Available N ◽  
Multiple Lesions ◽  
Molecular Features ◽  
Lineage Markers ◽  
Double Adenomas

Abstract Purpose Pituitary adenoma (PA) constitutes the third most common intracranial neoplasm. The mostly benign endocrine lesions express no hormone (null cell PA) or the pituitary hormone(s) of the cell lineage of origin. In 0.5–1.5% of surgical specimens and in up to 10% of autopsy cases, two or three seemingly separate PA may coincide. These multiple adenomas may express different hormones, but whether or not expression of lineage-restricted transcription factors and molecular features are distinct within multiple lesions remains unknown. Methods Searching the data bank of the German Pituitary Tumor Registry 12 double pituitary adenomas with diverse lineage were identified among 3654 adenomas and 6 hypophyseal carcinomas diagnosed between 2012 and 2020. The double adenomas were investigated immunohistochemically for expression of hormones and lineage markers. In addition, chromosomal gains and losses as well as global DNA methylation profiles were assessed, whenever sufficient material was available (n = 8 PA). Results In accordance with the literature, combinations of GH/prolactin/TSH–FSH/LH adenoma (4/12), GH/prolactin/TSH–ACTH adenoma (3/12), and ACTH–FSH/LH adenoma (3/12) were observed. Further, two out of 12 cases showed a combination of a GH/prolactin/TSH adenoma with a null-cell adenoma. Different expression pattern of hormones were confirmed by different expression of transcription factors in 11/12 patients. Finally, multiple lesions that were molecularly analysed in 4 patients displayed distinct copy number changes and global methylation pattern. Conclusion Our data confirm and extend the knowledge on multiple PA and suggest that such lesions may origin from distinct cell types.

Proposal of a clinically relevant working classification of PitNETs based on pituitary transcription factors.

2020 ◽  
Author(s):  
Sandra Silva-Ortega ◽  
Araceli García-Martinez ◽  
María Niveiro de Jaime ◽  
María Eugenia Torregrosa ◽  
Javier Abarca ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Pituitary Transcription Factors
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