Silent Myocardial Ischemia Is Associated with Autonomic Neuropathy and Other Cardiovascular Risk Factors in Type 1 and Type 2 Diabetic Subjects, Especially in Those with Microalbuminuria

Endocrine ◽  
2005 ◽  
Vol 27 (3) ◽  
pp. 213-218 ◽  
Author(s):  
Ana Chico ◽  
Antoni Tomás ◽  
Anna Novials
2016 ◽  
pp. 219-228 ◽  
Author(s):  
P. PIŤHOVÁ ◽  
K. ŠTECHOVÁ ◽  
J. PIŤHA ◽  
V. LÁNSKÁ ◽  
M. KVAPIL

Diabetes mellitus type 2 ranks among the strongest predictors of cardiovascular diseases (CVD) while the association of type 1 diabetes with CVD is more complex. We studied differences between type 1 and 2 diabetic women regarding association of cardiovascular risk factors with preclinical atherosclerosis expressed as intima-media thickness of common carotid (IMT CCA) and femoral arteries (IMT CFA) measured by high resolution ultrasound. Women with type 1 (n=203) and type 2 diabetes (n=123) were examined with regard to the presence of cardiovascular risk factors. In type 1 diabetic women strong association between IMT CCA and body mass index, waist circumference, and total body fat was found in contrast to type 2 diabetic women. In type 2 diabetic women strong association between IMT CCA and fasting glucose, glycated hemoglobin, and atherogenic index of plasma (log TG/HDL cholesterol) was observed in contrast to type 1 diabetic women. In type 1 diabetic women, IMT CFA was associated with body fat in contrast to type 2 diabetic women. Preclinical atherosclerosis in type 1 diabetic women was strongly associated with factors reflecting body fat and its distribution, while in type 2 diabetic women preclinical atherosclerosis was associated with markers reflecting glucose and lipid metabolic disorders.


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