Relationship Between Mammaglobin Expression and Estrogen Receptor Status in Breast Tumors

Endocrine ◽  
2003 ◽  
Vol 21 (3) ◽  
pp. 245-250 ◽  
Author(s):  
Xiao-feng Guan ◽  
Mohammad K. Hamedani ◽  
Adewale Adeyinka ◽  
Christina Walker ◽  
Angela Kemp ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Estrogen Receptor Status ◽  
Breast Tumors ◽  
Receptor Status

scholarly journals The prognostic potential of alternative transcript isoforms across human tumors

2016 ◽  
Author(s):  
Juan L. Trincado ◽  
E. Sebestyén ◽  
A. Pagés ◽  
E. Eyras
Keyword(s):  
Gene Expression ◽  
Estrogen Receptor ◽  
Lymph Node ◽  
Cancer Progression ◽  
Estrogen Receptor Status ◽  
Breast Tumors ◽  
The Cancer Genome Atlas ◽  
Alternative Transcript ◽  
Transcript Isoforms ◽  
Receptor Status

AbstractBackgroundPhenotypic changes during cancer progression are associated to alterations in gene expression, which can be exploited to build molecular signatures for tumor stage identification and prognosis. However, it is not yet known whether the relative abundance of transcript isoforms may be informative for clinical stage and survival.MethodsUsing information theory and machine learning methods, we integrated RNA sequencing and clinical data from The Cancer Genome Atlas project to perform the first systematic analysis of the prognostic potential of transcript isoforms in 12 solid tumors to build new predictive signatures for stage and prognosis. This study was also performed in breast tumors according to estrogen receptor status and melanoma tumors with proliferative and invasive phenotypes.ResultsTranscript isoform signatures accurately separate early from late stage and metastatic from non-metastatic tumors, and are predictive of the survival of patients with undetermined lymph node invasion or metastatic status. These signatures show similar, and sometimes better, accuracies compared with known gene expression signatures, and are largely independent of gene expression changes. Furthermore, we show frequent transcript isoform changes in breast tumors according to estrogen receptor status, and in melanoma tumors according to the invasive or proliferative phenotype, and derive accurate predictive models of stage and survival within each patient subgroup.ConclusionsOur analyses reveal new signatures based on transcript isoform abundances that characterize tumor phenotypes and their progression independently of gene expression. Transcript isoform signatures appear especially relevant to determine lymph node invasion and metastasis, and may potentially contribute towards current strategies of precision cancer medicine.

CAM26 and CAM29 Cytosol Levels in Breast Tumors Classified According to Estrogen Receptor Status. First Results

1992 ◽  
Vol 7 (2) ◽  
pp. 126-128 ◽  
Author(s):  
B. Suarez ◽  
C. González ◽  
MaT Allende ◽  
M Fdez Fdez ◽  
B. Fdez Llana ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Estrogen Receptor Status ◽  
Breast Tumors ◽  
Receptor Status ◽  
First Results

scholarly journals MicroRNA-9 as Potential Biomarker for Breast Cancer Local Recurrence and Tumor Estrogen Receptor Status

PLoS ONE ◽  
2012 ◽  
Vol 7 (6) ◽  
pp. e39011 ◽  
Author(s):  
Xin Zhou ◽  
Catalin Marian ◽  
Kepher H. Makambi ◽  
Ourania Kosti ◽  
Bhaskar V. S. Kallakury ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Local Recurrence ◽  
Estrogen Receptor Status ◽  
Receptor Status ◽  
Potential Biomarker

An immunohistochemical study of estrogen and progesterone receptors in adenocarcinoma of the endometrium and in the adjacent mucosa

1995 ◽  
Vol 5 (4) ◽  
pp. 275-281 ◽  
Author(s):  
H. Kerner ◽  
E. Sabo ◽  
M. Friedman ◽  
D. Beck ◽  
O. Samare ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Endometrial Cancer ◽  
Progesterone Receptor ◽  
Estrogen Receptor Status ◽  
Endometrial Adenocarcinoma ◽  
Progesterone Receptors ◽  
Myometrial Invasion ◽  
Inverse Correlation ◽  
Immunohistochemical Analysis ◽  
Receptor Status

The immunoperoxidase stain for estrogen and progesterone receptor content in endometrial adenocarcinoma was correlated with the grade and stage, level of myometrial invasion, age and survival of the patients. Anti-estrogen and anti-progesteone receptor monoclonal antibodies were applied to paraffin-embedded tissue from hysterectomy specimens of 100 patients with adenocarcinoma of the endometrium. In 34 of the cases the receptors were studied in the endometrium adjacent to the tumor and compared to the nuclear receptor content in the carcinoma. There was a high inverse correlation between the estrogen receptor status and the grade of tumor (R= − 0.45,P= 0.006). The estrogen receptor measured in the endometrium near the tumor showed a negative correlation with the grade of the tumor (R= −0.42,P= 0.013). The estrogen, but not the progesterone, receptor content, was positively related to the age of the patient (P< 0.05). No significant correlation of the receptor status with the depth of myometrial invasion was found, despite the obvious interdependence between the grade and myometrial invasion. The progesterone receptor staining index appeared to be a distinct independent prognostic factor in endometrial cancer. The immunohistochemical analysis of the steroid hormone status in endometrial cancer therefore offers an alternative to the quantitative ligand-binding assay.

The relationship of estrogen receptor status to DNA ploidy in breast cancer

Surgery Today ◽  
1992 ◽  
Vol 22 (2) ◽  
pp. 105-109 ◽  
Author(s):  
Atsuo Tsuchiya ◽  
Mitsuhiro Nihei ◽  
Yoshiro Ando ◽  
Shinichi Suzuki ◽  
Izo Kimijima ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Dna Ploidy ◽  
Estrogen Receptor Status ◽  
Receptor Status ◽  
Relationship Of ◽  
The Relationship

Estrogen-Receptor Status and Outcomes of Modern Chemotherapy for Patients With Node-Positive Breast Cancer

2006 ◽  
Vol 61 (9) ◽  
pp. 584-585
Author(s):  
Donald A. Berry ◽  
Constance Cirrincione ◽  
I Craig Henderson ◽  
Marc L. Citron ◽  
Daniel R. Budman ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Estrogen Receptor Status ◽  
Receptor Status ◽  
Node Positive ◽  
Positive Breast Cancer
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