Effects of Nitric Oxide Donors on Vascular Smooth Muscles Depend on a Type of Vascular Smooth-Muscle Preactivation

2002 ◽  
Vol 2 (2) ◽  
pp. 151-160 ◽  
Author(s):  
V V Lehen'kyi ◽  
S N Zelensky ◽  
A V Stefanov ◽  
A I Soloviev
Keyword(s):  
Nitric Oxide ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscles ◽  
Nitric Oxide Donors ◽  
Vascular Smooth Muscles

Mechanism of action of nitric oxide donors on voltage-activated calcium channels in vascular smooth muscle cells

1996 ◽  
Vol 28 (6) ◽  
pp. 232-239
Author(s):  
A. V. Zima ◽  
A. É. Belevich ◽  
A. V. Povstyan ◽  
M. I. Kharkhun ◽  
Ya. D. Tsitsyura ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Smooth Muscle ◽  
Calcium Channels ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Mechanism Of Action ◽  
Muscle Cells ◽  
Nitric Oxide Donors

scholarly journals Fluorescence demonstration of dipeptidyl peptidase II in skeletal, cardiac, and vascular smooth muscles.

1981 ◽  
Vol 29 (5) ◽  
pp. 672-677 ◽  
Author(s):  
W T Stauber ◽  
S H Ong
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Extensor Digitorum Longus ◽  
Smooth Muscles ◽  
Dipeptidyl Peptidase ◽  
Extensor Digitorum ◽  
Vascular Smooth Muscles ◽  
Normal Muscle ◽  
Muscle Tissues ◽  
Muscle Types

Dipeptidyl peptidase II (Dpp II) was demonstrated histochemically in soleus, extensor digitorum longus, cardiac, and vascular smooth muscle tissues using Lys-Ala-4-methoxy-beta-naphthylamide or Lys-Pro-4-methoxy-beta-naphthylamide as the substrate. The enzyme was found to be localized in discrete granules in all muscle types, but varied in its apparent activity. Dpp II activity was greatest in cardiac and least in extensor digitorum longus muscles with activity in soleus and vascular smooth muscles in between these extremes. Since Dpp II is localized only in lysosomes, the relative amounts and locales of lysosomes can be easily observed in normal muscle cells by the techniques described in this study.

Thrombin Prevents the Expression of Inducible Nitric Oxide Synthase in Vascular Smooth Muscle Cells by a Proteolytically-Activated Thrombin Receptor

1995 ◽  
Vol 74 (03) ◽  
pp. 980-986 ◽  
Author(s):  
Valérie B Schini-Kerth ◽  
Beate Fißithaler ◽  
Thomas T Andersen ◽  
John W Fenton ◽  
Paul M Vanhoutte ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Inducible Nitric Oxide Synthase ◽  
Muscle Cells ◽  
Thrombin Receptor ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

SummaryProteolytically active forms of thrombin (α- and γ-thrombin) and thrombin receptor peptides inhibited the release of nitrite, a stable endproduct of nitric oxide, evoked by interleukin-1 β(IL-1 β) in cultured vascular smooth muscle cells while proteolytically inactive forms [D-Phe-Pro-Arg chloromethyl ketone-α-thrombin (PPACK-α- thrombin) and diisopropylphosphoryl-α-thrombin (DIP-α-thrombin)] had either no or only minimal inhibitory effects. Under bioassay conditions, perfusates from columns containing IL-1 β-activated vascular smooth muscle cells or cells treated with IL-1βplus PPACK-α-thrombin relaxed detector blood vessels. These relaxations were abolished by the inhibitor of nitric oxide synthesis, NG-nitro-L arginine. No relaxations were obtained with untreated cells or IL-1 β-treated cells in the presence of α-thrombin. The expression of inducible nitric oxide synthase mRNA and protein in vascular smooth muscle cells by IL-1 β was impaired by α-thrombin. These results demonstrate that thrombin regulates the expression of the inducible nitric oxide synthase at a transcriptional level via the proteolytic activation of the thrombin receptor in vascular smooth muscle cells

Endothelin-1 Enhances Nitric Oxide–Induced Cytotoxicity in Vascular Smooth Muscle

Hypertension ◽  
1995 ◽  
Vol 25 (4) ◽  
pp. 744-747 ◽  
Author(s):  
Takeshi Nakahashi ◽  
Keisuke Fukuo ◽  
Takuo Inoue ◽  
Shigeto Morimoto ◽  
Shigeki Hata ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Endothelin 1

Nitric Oxide Induces Upregulation of Fas and Apoptosis in Vascular Smooth Muscle

Hypertension ◽  
1996 ◽  
Vol 27 (3) ◽  
pp. 823-826 ◽  
Author(s):  
Keisuke Fukuo ◽  
Shigeki Hata ◽  
Toshimitsu Suhara ◽  
Takeshi Nakahashi ◽  
Yoshitaka Shinto ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle
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