Binding of Mineral Elements to Locust Bean Gum Influences Availability In Vitro

2001 ◽  
Vol 81 (1) ◽  
pp. 79-92 ◽  
Author(s):  
Douwina Bosscher ◽  
Harry Robberecht ◽  
Rudy Van Cauwnebergh ◽  
Micheline Van Caillie-Bertrand ◽  
Hendrik Deelstra
Keyword(s):  
Mineral Elements ◽  
Locust Bean Gum ◽  
Locust Bean

scholarly journals Xanthan gum and Locust bean gum gel supports in vitro development of porcine oocytes derived from early antral follicles

2019 ◽  
Vol 65 (6) ◽  
pp. 551-554 ◽  
Author(s):  
Yasuhisa MUNAKATA ◽  
Ayaka SUGIMOTO ◽  
Koumei SHIRASUNA ◽  
Takehito KUWAYAMA ◽  
Hisataka IWATA
Keyword(s):  
Xanthan Gum ◽  
Locust Bean Gum ◽  
Antral Follicles ◽  
Locust Bean

scholarly journals Formulation and Evaluation of Floating Tablets of Cefpodoxime Proxetil

2014 ◽  
Vol 6 (3) ◽  
pp. 563-579 ◽  
Author(s):  
L. Kukati ◽  
K. Chittimalli ◽  
N. B. Shaik
Keyword(s):  
In Vitro Release ◽  
Locust Bean Gum ◽  
Floating Tablets ◽  
Cefpodoxime Proxetil ◽  
Zero Order Kinetics ◽  
Elimination Half ◽  
Locust Bean ◽  
Release Data ◽  
Gastro Retentive

In the present investigation, an attempt was made to develop gastro retentive tablets of cefpodoxime proxetil (CP) using locust bean gum as release retarded material. CP is an orally administered, extended spectrum, semi-synthetic antibiotic of cephalosporin class. CP has a short elimination half-life and also possesses high solubility, chemical, enzymatic stability and absorption profiles in acidic pH which makes CP suitable candidate for formulating it as gastro retentive dosage form for improved bioavailability. Sodium bicarbonate and citric acid were used as effervescent agents to get desired floating properties. The tablets prepared were evaluated and found to have acceptable physicochemical properties. The in vitro release data of optimized formulation was treated with mathematical equations and was concluded that drug release followed zero order kinetics with anomalous transport mechanism. Based on the results it can be concluded that floating tablets of cefpodoxime proxetil containing locust bean gum provides a better option for controlled release action and improved bioavailability. © 2014 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved. doi: http://dx.doi.org/10.3329/jsr.v6i3.18339 J. Sci. Res. 6 (3), 563-579 (2014)

scholarly journals FORMULATION DEVELOPMENT AND EVALUATION OF CHRONOMODULATED DRUG DELIVERY SYSTEM BY ZAFIRLUKAST

2021 ◽  
pp. 211-220
Author(s):  
N. SHIVA KRISHNA ◽  
B. JAYANTHI ◽  
A. MADHUKAR
Keyword(s):  
Drug Release ◽  
Lag Time ◽  
Early Morning ◽  
Release Profile ◽  
Locust Bean Gum ◽  
In Vitro Drug Release ◽  
The Core ◽  
Locust Bean ◽  
Core Tablet

Objective: The main objective of the present study was to formulate and evaluate a time-controlled single-unit oral pulsatile drug delivery system containing Zafirlukast for the prevention of nocturnal asthma attacks. To provide time-scheduled drug release for Asthma disease. It is used for preventing asthmatic attacks at early morning. Pulsatile release dosage form is increasing patient compliance by reducing the dosing frequency, especially in the early morning. Methods: Core tablets were prepared by incorporating different concentrations of natural and synthetic super disintegrants. Drug-containing core tablets (ZC1-ZC15) with different compositions of natural super disintegrants (Plantago ovata seed powder, Locust bean gum) synthetic super disintegrants (Sodium starch glycolate (SSG), Cross carmellose sodium (CCS), Crospovidone (CP)) were prepared by direct compression technique. The core tablets were subjected to pre-formulation, physicochemical and In vitro drug release studies. The fast disintegrating core tablet formulation was selected and press-coated tablets (P1-P11) were prepared with different compositions of hydrophobic polymers Eudragit RS100, Eudragit RL 100, Ethylcellulose and hydrophilic polymers Hydroxypropyl methylcellulose K4M, K100M. The optimized formulation was selected and quantified based on in vitro drug release profile in simulated gastric and intestinal fluids. Results: The pre and post-compression parameters of tablets were also found to be within limits. Formulation ZC5 with 16 mg of Locust bean gum showed the least disintegrating time, i.e., 22.13 sec, and was selected as the best immediate release core tablet. The press-coated tablet formulation P8 having 62.5 mg Eudragit RS100 and 62.5 mg of HPMC K4M in ratio 1:1 over the core tablet ZC5 showed rapid and drug release nearly after 4 h lag time and 98.86 % up to 12 h. Accelerated stability studies of the optimized formulation P8 indicated no significant difference in release profile after 3 mo. Conclusion: The in vitro dissolution study showed that lag time before drug release was highly affected by the coating amount level and nature of coating polymer used. Time-controlled pulsatile release tablets can be prepared using press-coating techniques.

scholarly journals Chitosan/sulfated locust bean gum nanoparticles: In vitro and in vivo evaluation towards an application in oral immunization

2017 ◽  
Vol 96 ◽  
pp. 786-797 ◽  
Author(s):  
Luis Braz ◽  
Ana Grenha ◽  
Domingos Ferreira ◽  
Ana M. Rosa da Costa ◽  
Carlos Gamazo ◽  
...  
Keyword(s):  
Oral Immunization ◽  
Locust Bean Gum ◽  
In Vivo Evaluation ◽  
Locust Bean

scholarly journals FORMULATION OF IMMEDIATE RELEASE (IR) ATORVASTATIN CALCIUM PELLETS AND SUSTAINED RELEASE (SR) GLIBENCLAMIDE FOR FIXED-DOSE COMBINATION DOSAGE FORM

2018 ◽  
Vol 11 (12) ◽  
pp. 159
Author(s):  
Kowshik K ◽  
Vishal Gupta N ◽  
Gowda Dv ◽  
Praveen Sivadasu
Keyword(s):  
Sustained Release ◽  
Guar Gum ◽  
Immediate Release ◽  
Fixed Dose ◽  
Locust Bean Gum ◽  
Atorvastatin Calcium ◽  
Dsc Studies ◽  
Ft Ir ◽  
Locust Bean

Objective: The objective of the present research was to develop fixed-dose combinations for the treatment of dyslipidemia, associated with type-II diabetes mellitus for improvement of glucose tolerance.Methods: Multiple unit pellet systems (MUPSs) consisting immediate release atorvastatin calcium pellets and sustained release glibenclamide were formulated by spheronization technique. The characterization of formulated pellets was done by Fourier transform infrared (FT-IR) and differential scanning calorimetry (DSC) studies, and formulated pellets were evaluated for solubility, viscosity, pH, and in vitro studies.Results: From FT-IR and DSC studies, it was confirmed that no chemical interaction existed between the drug and the natural polymers used. Solubility of glibenclamide was found to be 4.38 and 18.24 and atorvastatin calcium was found to be 6.84, 214.67, and 287.43 g/L. The viscosity of 1% w/v of locust bean gum, guar gum, and ghatti gum was found to be 169 cP, 124 cP, and 31 cP in distilled water. The pH of locust bean gum, guar gum, and gum ghatti solutions was found to be 5.6±0.49, 5.2±0.27, and 4.7±0.51. The in vitro studies suggested that glibenclamide pellets had shown a sustained release till 12 h, while atorvastatin calcium had shown immediate release of drug due to rapid disintegration of pellets.Conclusion: Thus, MUPS can be considered as an alternative approach to treat diabetes induced dyslipidemia.

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