Matrix Metalloproteinase Inhibitors in Cancer Therapy

2000 ◽  
Author(s):  
Neil J. Clendeninn ◽  
Krzysztof Appelt
Keyword(s):  
Cancer Therapy ◽  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase Inhibitors ◽  
Metalloproteinase Inhibitors

scholarly journals Bone-Seeking Matrix Metalloproteinase Inhibitors for the Treatment of Skeletal Malignancy

2020 ◽  
Vol 13 (6) ◽  
pp. 113
Author(s):  
Antonio Laghezza ◽  
Luca Piemontese ◽  
Leonardo Brunetti ◽  
Alessia Caradonna ◽  
Mariangela Agamennone ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Matrix Metalloproteinases ◽  
Matrix Metalloproteinase ◽  
Bone Remodeling ◽  
Cancer Progression ◽  
Tumor Invasion ◽  
Standard Care ◽  
Computational Analysis ◽  
Matrix Metalloproteinase Inhibitors ◽  
Metalloproteinase Inhibitors

Matrix metalloproteinases (MMPs) are a family of enzymes involved at different stages of cancer progression and metastasis. We previously identified a novel class of bisphosphonic inhibitors, selective for MMPs crucial for bone remodeling, such as MMP-2. Due to the increasing relevance of specific MMPs at various stages of tumor malignancy, we focused on improving potency towards certain isoforms. Here, we tackled MMP-9 because of its confirmed role in tumor invasion, metastasis, angiogenesis, and immuno-response, making it an ideal target for cancer therapy. Using a computational analysis, we designed and characterized potent MMP-2/MMP-9 inhibitors. This is a promising approach to develop and clinically translate inhibitors that could be used in combination with standard care therapy for the treatment of skeletal malignancies.

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