scholarly journals Direct Observation of Intramolecular Hydrogen-transfer Reactions Using Scanning Probe Microscopy

2018 ◽  
Vol 61 (10) ◽  
pp. 663-668
Author(s):  
Takashi KUMAGAI
Keyword(s):  
Direct Observation ◽  
Scanning Probe Microscopy ◽  
Hydrogen Transfer ◽  
Scanning Probe ◽  
Transfer Reactions ◽  
Probe Microscopy ◽  
Intramolecular Hydrogen ◽  
Hydrogen Transfer Reactions

Direct Observation of Corrosive Wear by In Situ Scanning Probe Microscopy

2020 ◽  
Vol 12 (20) ◽  
pp. 23543-23553
Author(s):  
J. Michael Shockley ◽  
Christopher R. So ◽  
Matthew J. Strom ◽  
Raymond C.Y. Auyeung ◽  
Derek J. Horton ◽  
...  
Keyword(s):  
Direct Observation ◽  
Scanning Probe Microscopy ◽  
Corrosive Wear ◽  
Scanning Probe ◽  
Probe Microscopy

scholarly journals Cysteine residues as catalysts for covalent peptide and protein modification: a role for thiyl radicals?

2011 ◽  
Vol 39 (5) ◽  
pp. 1254-1259 ◽  
Author(s):  
Christian Schöneich
Keyword(s):  
Oxidative Stress ◽  
Protein Modification ◽  
Hydrogen Transfer ◽  
Transfer Reactions ◽  
Hydrogen Deuterium Exchange ◽  
Amino Acid Residues ◽  
Thiyl Radicals ◽  
Hydrogen Deuterium ◽  
Intramolecular Hydrogen ◽  
Hydrogen Transfer Reactions

Cysteine thiyl radicals engage in reversible intramolecular hydrogen-transfer reactions with amino acid residues in peptides and proteins. These reactions can be experimentally demonstrated through covalent hydrogen–deuterium exchange when experiments are carried out in 2H2O. To this end, hydrogen-transfer reactions have been observed between cysteine thiyl radicals and glycine, alanine, serine, valine and leucine in both model peptides and a protein, insulin. The relevance of such reactions for protein oxidation under conditions of oxidative stress is discussed.

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