Pressure Support and Flow-Cycled, Assisted Mechanical Ventilation in Acute Lung Injury

CHEST Journal ◽  
1990 ◽  
Vol 98 (2) ◽  
pp. 458-462 ◽  
Author(s):  
Edward K. McGough ◽  
Michael J. Banner ◽  
Philip G. Boysen
Keyword(s):  
Mechanical Ventilation ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Pressure Support ◽  
Assisted Mechanical Ventilation

High oxygen concentrations predispose mouse lungsto the deleterious effects of high stretch ventilation

2003 ◽  
Vol 94 (3) ◽  
pp. 975-982 ◽  
Author(s):  
Timothy C. Bailey ◽  
Erica L. Martin ◽  
Lin Zhao ◽  
Ruud A. W. Veldhuizen
Keyword(s):  
Mechanical Ventilation ◽  
Acute Lung Injury ◽  
Lung Function ◽  
Lung Injury ◽  
Inflammatory Cytokines ◽  
Pulmonary Surfactant ◽  
Ex Vivo ◽  
Lung Stretch ◽  
Isolated Lungs ◽  
Mechanical Ventilation Group

Mechanical ventilation is a necessary intervention for patients with acute lung injury. However, mechanical ventilation can propagate acute lung injury and increase systemic inflammation. The exposure to >21% oxygen is often associated with mechanical ventilation yet has not been examined within the context of lung stretch. We hypothesized that mice exposed to >90% oxygen will be more susceptible to the deleterious effects of high stretch mechanical ventilation. C57B1/6 mice were randomized into 48-h exposure of 21 or >90% oxygen; mice were then killed, and isolated lungs were randomized into a nonstretch or an ex vivo, high-stretch mechanical ventilation group. Lungs were assessed for compliance and lavaged for surfactant analysis, and cytokine measurements or lungs were homogenized for surfactant-associated protein analysis. Mice exposed to >90% oxygen + stretch had significantly lower compliance, altered pulmonary surfactant, and increased inflammatory cytokines compared with all other groups. Our conclusion is that 48 h of >90% oxygen and high-stretch mechanical ventilation deleteriously affect lung function to a greater degree than stretch alone.

scholarly journals Fatal Ischaemic Stroke During COVID-19 and Acute Lung Injury

2020 ◽  
Author(s):  
Iris Duroi ◽  
Frederik Van Durme ◽  
Tony Bruyns ◽  
Sofie Louage ◽  
Alex Heyse
Keyword(s):  
Mechanical Ventilation ◽  
Acute Lung Injury ◽  
Respiratory Failure ◽  
Lung Injury ◽  
Ischaemic Stroke ◽  
Acute Ischaemic Stroke ◽  
Arterial Thrombosis ◽  
Deep Sedation

Severe COVID-19 may predispose to both venous and arterial thrombosis. We describe a patient with acute ischaemic stroke while suffering from COVID-19 and respiratory failure, necessitating mechanical ventilation. Deep sedation may delay diagnosis.

scholarly journals Risk Factors for Transfusion-Related Acute Lung Injury in Critical Patients Admitted in Intensive Care Unit: A Systematic Review and Meta-Analysis

2020 ◽  
Author(s):  
Lunyang Hu ◽  
Baoli Wang ◽  
Yong Jiang ◽  
Banghui Zhu ◽  
Chen Wang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Mechanical Ventilation ◽  
Acute Lung Injury ◽  
Blood Transfusion ◽  
Lung Injury ◽  
Chronic Alcohol ◽  
Related Factors ◽  
Chronic Alcohol Abuse ◽  
Related Risk ◽  
Critical Patients

Abstract Background: Until now, transfusion-related acute lung injury (TRALI) has been considered to be the leading cause of blood transfusion-related diseases and death. And there is no clinically effective treatment plan for TRALI. The aim of this study was to systematically summarize the literature on risk factors for TRALI in critical patients. Methods: Electronic searches (up to March 2020) were performed in the Cochrane Library, Web of Knowledge, Embase, and PubMed databases. We included studies reporting on the risk factors of TRALI for critical patients and extracted the risk factors. Finally, third studies met the inclusion criteria. Results: We summarized and analyzed the potential risk factors of TRALI for critical patients in 13 existing studies. The host-related factors were age (odds ratio (OR) [95% confidence interval] = 1.16 [1.08-1.24]), sex (OR = 1.26 [1.16-1.38]), tobacco use status (OR = 3.82 [1.91-7.65]), chronic alcohol abuse (OR = 3.82 [2.97-26.83]), fluid balance (OR = 1.24 [1.08-1.42]), shock before transfusion (OR = 4.41 [2.38-8.20]), and ASA score of the recipients (OR = 2.72 [1.43-5.16]). The transfusion-related factors were the number of transfusions (OR = 1.40 [1.14-1.72]) and fresh frozen plasma (FFP) units (OR = 1.21 [1.01-1.46]). The device-related factor was mechanical ventilation (OR = 4.13 [2.20-7.76]). Conclusions: The risk factors for TRALI in this study included age, sex, tobacco use, chronic alcohol abuse, fluid balance, shock before transfusion, ASA score, number of transfusions, FFP units and mechanical ventilation. Our study suggests that host-related risk factors play a more important role in the occurrence and development of TRALI than blood transfusion-related risk factors.

Proportional pressure support in acute lung injury

2002 ◽  
Vol 39 (7) ◽  
pp. 584-594 ◽  
Author(s):  
C. Capra ◽  
O. Somaini ◽  
P. Konrad
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Pressure Support
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