Combination High Dose Amrinone and Dopamine in the Management of Moribund Cardiogenic Shock After Open Heart Surgery

CHEST Journal ◽  
1988 ◽  
Vol 94 (3) ◽  
pp. 503-506 ◽  
Author(s):  
Kevin H. Olsen ◽  
Jeffrey Kluger ◽  
Arnold Fieldman
2005 ◽  
Vol 103 (6) ◽  
pp. 1113-1120 ◽  
Author(s):  
Nigel Humphreys ◽  
Simon M. Bays ◽  
Andrew J. Parry ◽  
Ashwinikumar Pawade ◽  
Robert S. Heyderman ◽  
...  

Background Extreme stress and inflammatory responses to open heart surgery are associated with increased morbidity and mortality. Based on both animal and adult human data, it was hypothesized that spinal anesthesia would be more effective at attenuating these responses than conventional high dose intravenous opioid techniques in infants and young children undergoing open heart surgery. Methods A prospective randomized controlled clinical trial was performed in 60 children aged up to 24 months undergoing open heart surgery. Patients were randomly assigned to receive either high-dose intravenous opioid or high-dose intravenous opioid plus spinal anesthesia. Spinal anesthesia was administered via an indwelling intrathecal catheter. Results Spinal anesthesia significantly reduced the stress responses as measured by plasma norepinephrine and epinephrine concentrations (both P < 0.05). Spinal anesthesia reduced plasma lactate concentrations (P < 0.05), but increased fluid requirements during the first postoperative day (P < 0.05). There were no differences in other cardiovascular parameters. Conclusions Continuous spinal anesthesia reduces stress responses in infants and young children undergoing cardiac surgery with cardiopulmonary bypass more effectively than high-dose intravenous opioids alone.


1985 ◽  
Vol 19 (1) ◽  
pp. 45-48 ◽  
Author(s):  
Johan Pillgram-Larsen ◽  
Finn Wisløff ◽  
JØRgen J. Jørgensen ◽  
Hans Chr. Godal ◽  
Gudmund Semb

1976 ◽  
Vol 10 (3) ◽  
pp. 231-235 ◽  
Author(s):  
Morten Kveim ◽  
Chr. Cappelen ◽  
Tor Frøysaker ◽  
Karl Victor Hall

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