Theoretic analysis of sites of aerosol deposition in the human lung

CHEST Journal ◽  
1981 ◽  
Vol 80 (6) ◽  
pp. 898-901 ◽  
Author(s):  
T. Gerrity ◽  
C. Garrard ◽  
D. Yeates
Keyword(s):  
Human Lung ◽  
Aerosol Deposition ◽  
Theoretic Analysis

scholarly journals Effect of gravity on aerosol dispersion and deposition in the human lung after periods of breath holding

2000 ◽  
Vol 89 (5) ◽  
pp. 1787-1792 ◽  
Author(s):  
Chantal Darquenne ◽  
Manuel Paiva ◽  
G. Kim Prisk
Keyword(s):  
Flow Rate ◽  
Turbulent Mixing ◽  
Direct Evidence ◽  
Human Lung ◽  
Hold Time ◽  
Aerosol Deposition ◽  
Breath Holding ◽  
Breath Hold ◽  
Constant Flow Rate ◽  
Aerosol Dispersion

To determine the extent of the role that gravity plays in dispersion and deposition during breath holds, we performed aerosol bolus inhalations of 1-μm-diameter particles followed by breath holds of various lengths on four subjects on the ground (1G) and during short periods of microgravity (μG). Boluses of ∼70 ml were inhaled to penetration volumes (Vp) of 150 and 500 ml, at a constant flow rate of ∼0.45 l/s. Aerosol concentration and flow rate were continuously measured at the mouth. Aerosol deposition and dispersion were calculated from these data. Deposition was independent of breath-hold time at both Vp in μG, whereas, in 1G, deposition increased with increasing breath hold time. At Vp = 150 ml, dispersion was similar at both gravity levels and increased with breath hold time. At Vp = 500 ml, dispersion in 1G was always significantly higher than in μG. The data provide direct evidence that gravitational sedimentation is the main mechanism of deposition and dispersion during breath holds. The data also suggest that cardiogenic mixing and turbulent mixing contribute to deposition and dispersion at shallow Vp.

Aerosol Deposition in the Human Lung Periphery Is Increased by Reduced-Density Gas Breathing

2008 ◽  
Vol 0 (0) ◽  
pp. 080225123426385-10
Author(s):  
Jonathan B. Peterson ◽  
G. Kim Prisk ◽  
Chantal Darquenne
Keyword(s):  
Human Lung ◽  
Aerosol Deposition ◽  
Lung Periphery ◽  
Reduced Density

scholarly journals Cardiogenic mixing increases aerosol deposition in the human lung in the absence of gravity

2013 ◽  
Vol 92 (1) ◽  
pp. 15-20 ◽  
Author(s):  
G. Kim Prisk ◽  
Rui Carlos Sá ◽  
Chantal Darquenne
Keyword(s):  
Human Lung ◽  
Aerosol Deposition

scholarly journals Pressurised aerosol deposition in the human lung with and without an "open" spacer device.

Thorax ◽  
1989 ◽  
Vol 44 (9) ◽  
pp. 706-710 ◽  
Author(s):  
S P Newman ◽  
A R Clark ◽  
N Talaee ◽  
S W Clarke
Keyword(s):  
Human Lung ◽  
Aerosol Deposition
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