Increased Serum Calcitonin Levels in Bronchogenic Cancer

CHEST Journal ◽  
1976 ◽  
Vol 69 (4) ◽  
pp. 495-499 ◽  
Author(s):  
Omega L. Silva ◽  
Kenneth L. Becker ◽  
Aron Primack ◽  
John L. Doppman ◽  
Richard H. Snider
Keyword(s):  
Serum Calcitonin ◽  
Bronchogenic Cancer

CALCITONIN HETEROGENEITY IN LUNG CANCER AND MEDULLARY THYROID CANCER

1978 ◽  
Vol 89 (1) ◽  
pp. 89-99 ◽  
Author(s):  
Kenneth L. Becker ◽  
Richard H. Snider ◽  
Omega L. Silva ◽  
Charles F. Moore
Keyword(s):  
Thyroid Cancer ◽  
Cancer Patients ◽  
Medullary Thyroid Cancer ◽  
Gel Filtration ◽  
Serum Calcitonin ◽  
Medullary Thyroid ◽  
Fraction I ◽  
Bronchogenic Cancer

ABSTRACT An investigation was made of the increased serum calcitonin in patients with medullary thyroid cancer and bronchogenic carcinoma in order to determine whether these conditions can be differentiated immunochemically. Endogenous fractions of immunoreactive calcitonin were separated by gel filtration and radioimmunoassayed with calcitonin antibodies having different region specificities. The pattern of serum heterogeneity of patients with medullary thyroid cancer was characterized by the presence of at least seven different fractions of immunoreactive calcitonin, ranging from fraction I (≧ 30 000 molecular weight (MW)) to fraction V (~ 2500 MW). In contrast, most patients with bronchogenic cancer had a predominance of high MW fractions (i. e. fractions I and II A). Following in vitro incubation of the serum, the typical large MW pattern of bronchogenic cancer serum could be converted to the more diffuse pattern seen in the serum of medullary thyroid cancer. We were able to differentiate, pre-operatively, the hypercalcitonaemia serum of medullary thyroid cancer patients from that of bronchogenic cancer patients by determination of the ratio of calcitonin as radioimmunoassayed with midportion versus carboxyl terminal antibody.

Molecular diagnosis and treatment of multiple endocrine neoplasia type 2B in Ethnic Han Chinese

2020 ◽  
Vol 20 ◽  
Author(s):  
Zhe-Wei Zhang ◽  
Xiao Guo ◽  
Xiao-Ping Qi
Keyword(s):  
Multiple Endocrine Neoplasia ◽  
Multiple Endocrine Neoplasia Type ◽  
Histopathological Examination ◽  
Diagnosis And Treatment ◽  
De Novo Mutation ◽  
Neck Lymph Node ◽  
Serum Calcitonin ◽  
Endocrine Neoplasia ◽  
Endocrine Neoplasia Type ◽  
Men 2B

Background: Multiple endocrine neoplasia type 2B (MEN 2B) is mainly caused by M918T RET germline mutation, and characterized by medullary thyroid carcinoma (MTC), pheochromocytoma (PHEO) and non-endocrine features. However, the diagnosis and treatment are usually delayed. Materials & Methods: This study reports 5 Chinese pedigrees with 5 individuals harboring germline RET-M918T, and systematically reviewed previous Chinese literatures. Results: All 5 patients initially presented MTC, but none had biochemically cured postoperatively. 2 also presented bilateral PHEO after adrenal-sparing surgery, 1 needed steroid replacement. Further, totally 32 MEN 2B patients from literatures were clustered with 28 available for analysis. 26 (92.8%) were diagnosed by endocrine-related symptoms; the remaining 2 (7.2%) due to RET testing and oral symptoms respectively. 25 patients underwent thyroidectomy with/without neck lymph node dissection at mean age of (23.3 ± 10.4) years. Histopathological examination revealed MTC (100%). Of them, 17 had definite TNM stage, with 1 in stage Ⅲ and others in Ⅳ. Other information of MEN 2B-related symptoms included penetrance of PHEO (60.7%), constipation (32.1%), Hirschsprung disease (25%), alacrima (17.8%), mucosal ganglioneuroma (96.4%) and marfanoid habitus (71.4%). 19 patients were verified harboring RET-M918T (c.2753T>C), of whom 15 (78.9%) were de novo mutation. The other 9 were clinically diagnosed as MEN 2B. Discussion & Conclusion : The initial diagnosis of MEN 2B is relatively later, and diagnosed by non-endocrine components is extremely lower. Recognition of MEN 2B and its non-endocrine-related components is still the utmost requirement for a Chinese physician. Combined RET screening and serum calcitonin detection can facilitate early diagnosis.

scholarly journals Interest of Routine Measurement of Serum Calcitonin: Study in a Large Series of Thyroidectomized Patients

1997 ◽  
Vol 82 (2) ◽  
pp. 338-341 ◽  
Author(s):  
Patricia Niccoli ◽  
Nelly Wion-Barbot ◽  
Philippe Caron ◽  
Jean-Francois Henry ◽  
Catherine de Micco ◽  
...  
Keyword(s):  
Large Series ◽  
Serum Calcitonin ◽  
Routine Measurement

RADIOLOGIC MANIFESTATIONS OF BRONCHOGENIC CANCER

1993 ◽  
Vol 14 (1) ◽  
pp. 55-67
Author(s):  
Charles S. White ◽  
Philip A. Templeton
Keyword(s):  
Bronchogenic Cancer

Bronchogenic Cancer in Patients Under 40 Years Old

CHEST Journal ◽  
1993 ◽  
Vol 104 (5) ◽  
pp. 1477-1481 ◽  
Author(s):  
Leon S. Green ◽  
Teresa I. Fortoul ◽  
Guadalupe Ponciano ◽  
Carlos Robles ◽  
Octavio Rivero
Keyword(s):  
Bronchogenic Cancer

scholarly journals Usefulness of preoperative serum calcitonin in patients with nodular thyroid disease without suspicious history or cytology for medullary thyroid carcinoma

2013 ◽  
Vol 57 (4) ◽  
pp. 312-316 ◽  
Author(s):  
Pedro Weslley Rosário ◽  
Gustavo Cancela Penna ◽  
Kamilla Brandão ◽  
Bárbara Érika Souza
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Multiple Endocrine Neoplasia ◽  
Multiple Endocrine Neoplasia Type ◽  
Serum Calcitonin ◽  
Medullary Thyroid ◽  
Endocrine Neoplasia ◽  
Preoperative Serum ◽  
History Of

OBJECTIVE: To evaluate the usefulness of preoperative serum calcitonin (sCT) in patients with nodular disease without suspicion of medullary thyroid carcinoma (MTC) in history or cytology. PATIENTS AND METHODS: sCT was measured before thyroidectomy in 494 patients with nodular disease who had no family history of MTC or multiple endocrine neoplasia type 2, and no cytological suspicion of MTC. RESULTS: Basal sCT was < 10 ng/mL in 482 patients and none of them had MTC. One patient with basal sCT > 100 pg/mL had MTC. Among the 11 patients with basal sCT between 10 and 100 pg/mL, MTC was diagnosed in only one. The two patients with MTC were submitted to total thyroidectomy, combined with elective lymph node dissection indicated exclusively based on hypercalcitoninemia, and sCT was undetectable after six months. CONCLUSIONS: Preoperative sCT is useful for the detection of sporadic MTC in patients with nodular disease, even in the absence of suspicious history or cytology.

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