Dysfunction of the Right Ventricle in Coronary Artery Disease

CHEST Journal ◽  
1974 ◽  
Vol 66 (3) ◽  
pp. 230-235 ◽  
Author(s):  
David E. Wells ◽  
Benjamin Befeler
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Right Ventricle ◽  
Artery Disease ◽  
The Right

scholarly journals Genetic analysis of coronary artery disease using tree-based automated machine learning informed by biology-based feature selection

2021 ◽  
Author(s):  
Elisabetta Manduchi ◽  
Trang T. Le ◽  
Weixuan Fu ◽  
Jason H. Moore
Keyword(s):  
Machine Learning ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Drug Targets ◽  
Nucleotide Polymorphisms ◽  
Individual Level ◽  
Importance Analysis ◽  
Artery Disease ◽  
The Uk ◽  
The Right

AbstractMachine Learning (ML) approaches are increasingly being used in biomedical applications. Important challenges of ML include choosing the right algorithm and tuning the parameters for optimal performance. Automated ML (AutoML) methods, such as Tree-based Pipeline Optimization Tool (TPOT), have been developed to take some of the guesswork out of ML thus making this technology available to users from more diverse backgrounds. The goals of this study were to assess applicability of TPOT to genomics and to identify combinations of single nucleotide polymorphisms (SNPs) associated with coronary artery disease (CAD), with a focus on genes with high likelihood of being good CAD drug targets. We leveraged public functional genomic resources to group SNPs into biologically meaningful sets to be selected by TPOT. We applied this strategy to data from the UK Biobank, detecting a strikingly recurrent signal stemming from a group of 28 SNPs. Importance analysis of these uncovered functional relevance of the top SNPs to genes whose association with CAD is supported in the literature and other resources. Furthermore, we employed game-theory based metrics to study SNP contributions to individual level TPOT predictions and discover distinct clusters of well-predicted CAD cases. The latter indicates a promising approach towards precision medicine.

scholarly journals Multi-Vessel Coronary Artery Disease: Choice of Myocardial Revascularization Strategy

2020 ◽  
Vol 27 (4) ◽  
pp. E202041
Author(s):  
Nestor Seredyuk ◽  
Andrii Matlakh ◽  
Yaroslava Vandzhura ◽  
Mykyta Bielinskyi ◽  
Oleksii Skakun ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Percutaneous Coronary Intervention ◽  
Coronary Artery ◽  
Right Coronary Artery ◽  
Myocardial Revascularization ◽  
Coronary Intervention ◽  
Percutaneous Coronary ◽  
Artery Disease ◽  
The Right

Multi-vessel coronary artery disease is quite a common state, which is often diagnosed by coronary angiography in patients with both stable coronary artery disease and acute coronary syndromes. Major difficulties in percutaneous coronary intervention include stent thrombosis and the need for antiplatelet therapy (aspirin and a P2Y12 inhibitor). Stent thrombosis leads to the recurrence of myocardial infarction and may occur within the first few hours after percutaneous coronary intervention. The use of dual antiplatelet therapy, especially that combined with low-molecular-weight heparin in the first days after myocardial infarction, poses a risk of bleeding, which often occurs in real clinical practice. Among P2Y12  inhibitors, ticagrelor causes bleeding somewhat more frequently than clopidogrel. A case of multi-vessel coronary artery disease is described in this paper. Coronary angiography revealed right-dominant circulation; occlusion of the proximal and medial segments of the right coronary artery, thrombolysis in myocardial infarction flow grade 0; stenosis of the left main coronary artery (50-60%), thrombolysis in myocardial infarction flow grade 2; diffuse stenosis of the medial and distal segments of the left anterior descending artery, thrombolysis in myocardial infarction flow grade 1; stenosis of the proximal segment of the left circumflex artery (> 75%), thrombolysis in myocardial infarction flow grade 1. The patient underwent percutaneous coronary intervention; the stents were implanted in the infarct-dependent right coronary artery. The clinical course was complicated by early stent thrombosis with subsequent thrombus extraction; a day later melena developed. Bleeding was stopped, the intensity of antithrombotic therapy was reduced: the combination of aspirin and ticagrelor was replaced by the combination of aspirin and clopidogrel. Six weeks after stenting of the infarct-dependent coronary artery, complete myocardial revascularization (hybrid intervention) was performed: coronary artery bypass grafting [the left internal mammary artery → the left anterior descending artery], coronary autogenous bypass grafting [the aorta → the right coronary artery and the aorta → the left circumflex artery]. The role of fractional flow reserve or instantaneous wave-free ratio-controlled complete myocardial revascularization techniques is discussed. The following algorithm for myocardial revascularization was used: percutaneous coronary intervention for the right coronary artery + coronary artery bypass grafting-3: the left internal mammary artery → the left anterior descending artery, the aorta → the left circumflex artery, the aorta → the right coronary artery.

2008 Ancel Keys Memorial Lecture—Screening for Coronary Artery Disease: Is It Too Soon to Think Clinically?

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Michael Lauer
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Healthy Person ◽  
Evidence Base ◽  
Western Society ◽  
Memorial Lecture ◽  
Clinical Events ◽  
Artery Disease ◽  
Clinical Thinking ◽  
The Right

Screening is a mainstay of modern preventive medicine. Physicians routinely screen patients for breast or colorectal cancer, as well as hypertension, hypercholesterolemia, and abdominal aortic aneurysm. In each of these cases, randomized trials demonstrated that screening saves lives or prevents major morbidity. As coronary artery disease remains the number one cause of death in Western society, there is interest in screening for the disease itself, as opposed to just its risk factors. Some investigators have argued for routine screening of adults with coronary artery calcium testing; proponents have used direct-to-consumer advertising, legislative lobbying, and appeals in the mass media. Although it is true that coronary calcium scores correlate well with clinical events, the evidence base has not yet reached the level of established tests. We may fall into a too-often ignored trap, where strategies based on logic or risk markers turn out to be ineffective or even dangerous. When a seemingly healthy person undergoes a screening test and is found to have disease, that person becomes a patient subject to clinical thinking. If this translates into improved outcome, clinical thinking is appropriate. We must remember, though, that screening is supposed to prevent clinical events. When it merely detects subclinical disease, leading to unnecessary tests or procedures, it instead exposes people to the risks of thinking clinically. We must have the ambition, willingness, and patience to develop the evidence base needed to introduce new screening technologies to the clinic at the right time.

scholarly journals ISOLATED RIGHT VENTRICLE INFARCTION IN A PATIENT WITH RADIOTHERAPY-INDUCED CORONARY ARTERY DISEASE

2020 ◽  
Vol 75 (11) ◽  
pp. 3440
Author(s):  
Lukas Salazar ◽  
Juan Vasquez ◽  
Nathalie Rosas ◽  
Fernando Andres Rada Bucheli ◽  
Hector Medina
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Right Ventricle ◽  
Artery Disease

scholarly journals 262 An attractive endovascular strategy for combined—aneurysmal and stenotic—coronary artery disease

2021 ◽  
Vol 23 (Supplement_G) ◽  
Author(s):  
Fauzia Vendrametto ◽  
Alessandro Pierri ◽  
Davide Barbisan ◽  
Rita Piazza ◽  
Daniela Pavan ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Multidisciplinary Approach ◽  
Revascularization Procedure ◽  
Artery Disease ◽  
The Right ◽  
Adjacent Segments ◽  
Carotid Wallstent ◽  
Stenotic Lesions ◽  
Vessel Coronary Artery

Abstract In patients undergoing coronary angiography the coexistence of aneurysmal and stenotic lesions in adjacent segments of the same epicardial vessel is uncommon. We describe a rare case of single-vessel coronary artery disease (CAD) in a 70-year-old male, presenting with progressive effort-induced angina of 3-months’ evolution. The coronary angiogram revealed a critical calcified stenosis in the context of diffuse ectasia affecting the right coronary artery (RCA). Our report focuses on a complex revascularization procedure using the self-expandable Carotid Wallstent. Highlighting the importance of a multidisciplinary approach, we provide an original and effective endovascular solution for an unusual pathological angiographic finding, which could be of potential interest for interventional cardiologists.

Sign in / Sign up

Export Citation Format

Share Document