Comparative Study between Bacteriologic Findings in Patients with Pulmonary Tuberculosis and Bacteriology of Surgically Resected Lung Tissue

1964 ◽  
Vol 46 (1) ◽  
pp. 37-41
Author(s):  
GLADIS EVELINA AMADÍO ◽  
JOSÉ ANTONIO PÉREZ ◽  
NILDA CAFURE ◽  
CAMILIO ENRIQUE FARÍAS ◽  
REMIGIO CAMINOS
Keyword(s):  
Pulmonary Tuberculosis ◽  
Comparative Study ◽  
Lung Tissue

Rifabutin for the treatment of newly-diagnosed pulmonary tuberculosis: a multinational, randomized, comparative study versus rifampicin

1994 ◽  
Vol 75 (5) ◽  
pp. 341-347 ◽  
Author(s):  
L.J. Gonzalez-Montaner ◽  
S. Natal ◽  
P. Yongchaiyud ◽  
P. Olliaro ◽  
E. Abbate ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Comparative Study ◽  
Newly Diagnosed

scholarly journals Lung Tissue Distribution After Intravenous Administration of Grepafloxacin: Comparative Study With Levofloxacin

2002 ◽  
Vol 88 (1) ◽  
pp. 63-68 ◽  
Author(s):  
Hiroshi Yamamoto ◽  
Tomonobu Koizumi ◽  
Masao Hirota ◽  
Toshimichi Kaneki ◽  
Hitoshi Ogasawara ◽  
...  
Keyword(s):  
Comparative Study ◽  
Tissue Distribution ◽  
Lung Tissue ◽  
Intravenous Administration

A CT-based comparative study of radiological patterns of pulmonary tuberculosis in patients with type 2 diabetes versus non-diabetics

2016 ◽  
Vol 37 (2) ◽  
pp. 206-214
Author(s):  
Amit Nandan Dhar Dwivedi ◽  
Kamlakar Tripathi ◽  
Jai Krishna Mishra ◽  
Ashish Upadhyay ◽  
Rajeev Singh ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Pulmonary Tuberculosis ◽  
Comparative Study ◽  
Radiological Patterns

scholarly journals Lung Tissue Concentrations of Pyrazinamide among Patients with Drug-Resistant Pulmonary Tuberculosis

2017 ◽  
Vol 61 (6) ◽  
Author(s):  
Russell R. Kempker ◽  
M. Tobias Heinrichs ◽  
Ketino Nikolaishvili ◽  
Irina Sabulua ◽  
Nino Bablishvili ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Lung Tissue ◽  
Ex Vivo ◽  
Inverse Correlation ◽  
Drug Resistant ◽  
Tissue Penetration ◽  
Serum Samples ◽  
Tissue Samples ◽  
Content Type ◽  
Antituberculosis Treatment

ABSTRACT Improved knowledge regarding the tissue penetration of antituberculosis drugs may help optimize drug management. Patients with drug-resistant pulmonary tuberculosis undergoing adjunctive surgery were enrolled. Serial serum samples were collected, and microdialysis was performed using ex vivo lung tissue to measure pyrazinamide concentrations. Among 10 patients, the median pyrazinamide dose was 24.7 mg/kg of body weight. Imaging revealed predominant lung lesions as cavitary (n = 6 patients), mass-like (n = 3 patients), or consolidative (n = 1 patient). On histopathology examination, all tissue samples had necrosis; eight had a pH of ≤5.5. Tissue samples from two patients were positive for Mycobacterium tuberculosis by culture (pH 5.5 and 7.2). All 10 patients had maximal serum pyrazinamide concentrations within the recommended range of 20 to 60 μg/ml. The median lung tissue free pyrazinamide concentration was 20.96 μg/ml. The median tissue-to-serum pyrazinamide concentration ratio was 0.77 (range, 0.54 to 0.93). There was a significant inverse correlation between tissue pyrazinamide concentrations and the amounts of necrosis (R = −0.66, P = 0.04) and acid-fast bacilli (R = −0.75, P = 0.01) identified by histopathology. We found good penetration of pyrazinamide into lung tissue among patients with pulmonary tuberculosis with a variety of radiological lesion types. Our tissue pH results revealed that most lesions had a pH conducive to pyrazinamide activity. The tissue penetration of pyrazinamide highlights its importance in both drug-susceptible and drug-resistant antituberculosis treatment regimens.

A comparative study of the socio-economic risk factors for pulmonary tuberculosis in the Saharia tribe of Madhya Pradesh, India

2018 ◽  
Vol 112 (6) ◽  
pp. 272-278 ◽  
Author(s):  
Vikas Gangadhar Rao ◽  
Jyothi Bhat ◽  
Rajiv Yadav ◽  
Ravendra Kumar Sharma ◽  
Malaisamy Muniyandi
Keyword(s):  
Risk Factors ◽  
Pulmonary Tuberculosis ◽  
Comparative Study ◽  
Madhya Pradesh ◽  
Economic Risk

Over-expression of thymosin β4 in granulomatous lung tissue with active pulmonary tuberculosis

Tuberculosis ◽  
2014 ◽  
Vol 94 (3) ◽  
pp. 323-331 ◽  
Author(s):  
Yun-Jeong Kang ◽  
Jin-Ok Jo ◽  
Mee Sun Ock ◽  
Young-Bin Yoo ◽  
Bong-Kwon Chun ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Lung Tissue ◽  
Thymosin Β4 ◽  
Active Pulmonary Tuberculosis ◽  
Over Expression
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