The Role of Cortical Arousals as an Indicator of Poor Sleep Quality in the Reduction of Blood Pressure Under Long-term CPAP Therapy for Obstructive Sleep Apnea and Resistant Hypertension

CHEST Journal ◽  
2015 ◽  
Vol 148 (4) ◽  
pp. 1057A
Author(s):  
Oana-Claudia Deleanu ◽  
Andra Malaut ◽  
Ana Maria Nebunoiu ◽  
Alexandra Roberta Sandu ◽  
Valentin Caius Cosei ◽  
...  
2017 ◽  
Vol 63 (12) ◽  
pp. 1055-1060 ◽  
Author(s):  
Marcelo Rodrigues Bacci ◽  
Jonathan Naim Mora Emboz ◽  
Beatriz da Costa Aguiar Alves ◽  
Glaucia Luciano da Veiga ◽  
Neif Murad ◽  
...  

Summary Introduction: Obstructive sleep apnea and hypopnea syndrome (OSAHS) is one of the developmental factors of high blood pressure (HBP), a relevant global public health problem. OSAHS is characterized by the reduction or complete cessation of respiratory airflow due to intermittent airway collapse. Additionally, significant changes in sleep rhythm and pattern are observed in these patients. Objective: To evaluate the association between OSAHS and sleep quality in essential and resistant hypertensives. Method: A cross-sectional, observational study evaluated 43 hypertensive patients treated at the outpatient clinics of the Faculdade de Medicina do ABC (FMABC) who were medicated with two or more antihypertensive drugs and divided into nonresistant or resistant to treatment. Results: Group I (using up to two antihypertensive agents – 60.47% of the sample) presented mean systolic blood pressure (SBP) of 127.5±6.4 mmHg, mean diastolic blood pressure (DBP) of 79.6±5.2 mmHg, mean body mass index (BMI) of 27.2±5.3 kg/m2 and mean age of 51.2±15.1 years. Group II (using more than two antihypertensive drugs – 37.2% of the sample) presented mean SBP of 132.1±9.3 mmHg, mean DBP of 84.5±5.8 mmHg, mean BMI of 27.2±7.2 kg/m2 and mean age of 55.5±13.4 years. The patients presented low quality of sleep/sleep disorder evaluated by the Pittsburgh Sleep Quality Index (PSQI), which represents a preponderant factor for OSAHS. Conclusion: Patients at high risk for OSAHS had poor sleep quality and high levels of DBP, suggesting a causal relation between these parameters. However, they did not present a higher prevalence of resistant high blood pressure (RHBP).


2019 ◽  
Vol 81 (3-4) ◽  
pp. 190-196
Author(s):  
Byung Joon Kim ◽  
Kang Min Park

Background: Both obstructive sleep apnea (OSA) and obesity are associated with poor sleep quality. However, there have been no studies investigating sleep quality in OSA patients with obesity. The aims of this study were to (1) evaluate the sleep quality in OSA patients with obesity and (2) identify the parameters most related to sleep quality in OSA patients with obesity. Methods: Of the patients with polysomnography (PSG), OSA patients with obesity (body mass index [BMI] ≥25) were enrolled and then divided into 2 groups based on the Pittsburg Sleep Questionnaire Index (PSQI): patients with good sleep quality (PSQI ≤5, good sleepers) and those with poor sleep quality (PSQI >5, poor sleepers). In addition, we enrolled OSA patients without obesity as a disease control group. Results: Eighty-two OSA patients with obesity met the inclusion criteria (28 were good sleepers, whereas 54 were poor sleepers). We found that the BMI of the poor sleepers was significantly higher than that of the good sleepers, whereas the N-stage sleep ratio of good sleepers was higher than that of poor sleepers. Logistic ­regression analysis also showed that a high BMI and low ­N-stage sleep ratio were independently associated with poor sleep quality. In addition, BMI and N-stage sleep ratio were significantly correlated with PSQI. However, in 56 OSA patients (n = 56) without obesity, there were no differences of demographic/clinical characteristics and PSG parameters between the good (n = 18) and poor sleepers (n = 38). Discussions: About two-thirds of OSA patients with obesity show poor sleep quality. The sleep quality of these patients was more affected by the severity of obesity, but not the severity of OSA. Thus, we recommend weight loss in OSA patients with obesity to improve sleep quality as well as the severity of OSA.


Respiration ◽  
2015 ◽  
Vol 89 (5) ◽  
pp. 416-419 ◽  
Author(s):  
Olivier Contal ◽  
Jean Louis P�pin ◽  
Jean Christian Borel ◽  
Fabrice Espa ◽  
Stephen Perrig ◽  
...  

2017 ◽  
Vol 24 (4) ◽  
pp. 385-392
Author(s):  
Diana Cristina Protasiewicz ◽  
Adina Popa ◽  
Maria-Magdalena Roşu ◽  
Adela-Gabriela Firănescu ◽  
Simona Georgiana Popa ◽  
...  

AbstractHumans spend almost one third of their life sleeping, thus sleep deprivation or poor sleep quality will have consequences upon the quality of life. Obstructive sleep apnea (OSA) is the most common sleep disorder that represents a respiratory cessation for at least ten seconds, which appears repeatable during sleep and it is accompanied by decreased oxygen saturation. The diagnosis of OSA is possible by filling in the STOP, STOP BANG, BERLIN questionnaires and performing the polysomnography, an accessible and more accurate method but yet very expensive. The prevalence of OSA is continuously increasing, but because of the nonspecific symptoms, the percentage of un-diagnosed cases is further increased. Data from 11 epidemiological studies published between 1993 and 2014 indicated an OSA prevalence of 22% in men and 17% in women. It has been suggested that there is a bidirectional causal relationship between OSA and obesity, and numerous studies have shown association of OSA with insulin resistance, diabetes mellitus, diabetic micro- and macrovascular complications and atrial fibrillation.


2017 ◽  
Vol 69 (5) ◽  
pp. 742-747 ◽  
Author(s):  
Joule J. Li ◽  
Sarah L. Appleton ◽  
Tiffany K. Gill ◽  
Andrew Vakulin ◽  
Gary A. Wittert ◽  
...  

CHEST Journal ◽  
2005 ◽  
Vol 128 (4) ◽  
pp. 223S
Author(s):  
Tanveer Ahmed ◽  
Joe G. Zein ◽  
Walid G. Younis ◽  
Fazal Ali ◽  
Maroun M. Tawk ◽  
...  

2013 ◽  
Vol 26 (3) ◽  
pp. 346-352 ◽  
Author(s):  
M. F. Vela ◽  
J. R. Kramer ◽  
P. A. Richardson ◽  
R. Dodge ◽  
H. B. El-Serag

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