In Vivo Coregistered Doppler Optical Coherence Tomography and Autofluorescence Imaging of Peripheral Lung Cancers

CHEST Journal ◽  
2015 ◽  
Vol 148 (4) ◽  
pp. 792A
Author(s):  
Wei Zhang ◽  
Alexander Ritchie ◽  
Hamid Pahlevaninezhad ◽  
Anthony Lee ◽  
Geoffrey Hohert ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence ◽  
Autofluorescence Imaging ◽  
Lung Cancers ◽  
Peripheral Lung ◽  
Doppler Optical Coherence Tomography

Doppler optical coherence tomography and co-registered autofluorescence imaging of peripheral lung cancer

2015 ◽  
Author(s):  
Wei Zhang ◽  
Alexander J. Ritchie ◽  
Hamid Pahlevaninezhad ◽  
Anthony M. D. Lee ◽  
Geoffrey Hohert ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Optical Coherence Tomography ◽  
Optical Coherence ◽  
Autofluorescence Imaging ◽  
Peripheral Lung Cancer ◽  
Peripheral Lung ◽  
Doppler Optical Coherence Tomography

In vivo feasibility of endoscopic catheter-based Doppler optical coherence tomography

2003 ◽  
Vol 124 (4) ◽  
pp. A49-A50 ◽  
Author(s):  
Victor X.D. Yang ◽  
Bing Qi ◽  
Maggie L. Gordon ◽  
Emily Seng Yue ◽  
Stuart Bisland ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence ◽  
Doppler Optical Coherence Tomography

scholarly journals In vivo label-free measurement of lymph flow velocity and volumetric flow rates using Doppler optical coherence tomography

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Cedric Blatter ◽  
Eelco F. J. Meijer ◽  
Ahhyun S. Nam ◽  
Dennis Jones ◽  
Brett E. Bouma ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Flow Velocity ◽  
Lymph Flow ◽  
Optical Coherence ◽  
Label Free ◽  
Flow Rates ◽  
Doppler Optical Coherence Tomography

scholarly journals Micro-Heterogeneity of Flow in a Mouse Model of Chronic Cerebral Hypoperfusion Revealed by Longitudinal Doppler Optical Coherence Tomography and Angiography

2015 ◽  
Vol 35 (10) ◽  
pp. 1552-1560 ◽  
Author(s):  
Vivek J Srinivasan ◽  
Esther Yu ◽  
Harsha Radhakrishnan ◽  
Anil Can ◽  
Mihail Climov ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Capillary Density ◽  
Chronic Cerebral Hypoperfusion ◽  
Cerebral Hypoperfusion ◽  
Oct Angiography ◽  
Imaging Method ◽  
Optical Coherence ◽  
Doppler Optical Coherence Tomography ◽  
Longitudinal Imaging

Although microvascular dysfunction accompanies cognitive decline in aging, vascular dementia, and Alzheimer's disease, tools to study microvasculature longitudinally in vivo are lacking. Here, we use Doppler optical coherence tomography (OCT) and angiography for noninvasive, longitudinal imaging of mice with chronic cerebral hypoperfusion for up to 1 month. In particular, we optimized the OCT angiography method to selectively image red blood cell (RBC)-perfused capillaries, leading to a novel way of assessing capillary supply heterogeneity in vivo. After bilateral common carotid artery stenosis (BCAS), cortical blood flow measured by Doppler OCT dropped to half of baseline throughout the imaged tissue acutely. Microscopic imaging of the capillary bed with OCT angiography further revealed local heterogeneities in cortical flow supply during hypoperfusion. The number of RBC-perfused capillaries decreased, leading to increased oxygen diffusion distances in the days immediately after BCAS. Linear regression showed that RBC-perfused capillary density declined by 0.3% for a drop in flow of 1 mL/100 g per minute, and decreases in RBC-perfused capillary density as high as 25% were observed. Taken together, these results demonstrate the existence of local supply heterogeneity at the capillary level even at nonischemic global flow levels, and demonstrate a novel imaging method to assess this heterogeneity.

Sign in / Sign up

Export Citation Format

Share Document