Diffuse Alveolar Hemorrhage: A Rare Complication of Henoch-Schönlein Purpura Successfully Treated With Rituximab

CHEST Journal ◽  
2014 ◽  
Vol 146 (4) ◽  
pp. 203A ◽  
Author(s):  
Tony Abdo ◽  
Ali Jabari ◽  
Joseph Meharg
2008 ◽  
Vol 23 (5) ◽  
pp. 821-825 ◽  
Author(s):  
Ekaterini Siomou ◽  
Anastasios Serbis ◽  
Christos Salakos ◽  
Frederica Papadopoulou ◽  
Constantinos J. Stefanidis ◽  
...  

2002 ◽  
Vol 8 (5) ◽  
pp. 287-288 ◽  
Author(s):  
Antonio Teixeira ◽  
Thierry Genereau ◽  
Laurent Sutton ◽  
Serge Herson ◽  
Patrick Cherin

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Iliyana H. Pacheva ◽  
Ivan S. Ivanov ◽  
Krastina Stefanova ◽  
Elena Chepisheva ◽  
Lyubov Chochkova ◽  
...  

Central nervous system (CNS) involvement in Henoch-Schonlein purpura (HSP) is rare but poses diagnostic difficulties. The aim of the study was to establish the frequency of CNS involvement in HSP, to analyze its clinical characteristics and do a literature review. Medical files of patients with HSP admitted at the Department of Pediatrics, Plovdiv, were studied retrospectively for a five-year period (2009–2013). Diagnosis was based on the American College of Rheumatology criteria. Out of 112 children with HSP 1 case (0.9%) had CNS involvement presenting as Posterior Reversible Encephalopathy Syndrome (PRES), which may be a result of CNS vasculitis or arterial hypertension. It was an 8-year-old girl with atypical HSP which started with abdominal pain requiring surgery. On the third day after the operation a transient macular rash and arterial hypertension appeared, followed by visual disturbances, hemiconvulsive epileptic seizures, postictal hemiparesis, and confusion. Head CT showed occipital hypodense lesions and MRT-T2 hyperintense lesion in the left occipital lobe. The patient experienced a second similar episode after 2 weeks when palpable purpura had also appeared. Neurological symptoms and MRI resolved completely. HSP can be an etiological factor for PRES in childhood. Although PRES is a rare complication of HSP, clinicians must be aware of it and avoid diagnostic and therapeutic delays.


2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Giada Maria Di Pietro ◽  
Massimo Luca Castellazzi ◽  
Antonio Mastrangelo ◽  
Giovanni Montini ◽  
Paola Marchisio ◽  
...  

Abstract Background Henoch-Schönlein Purpura (HSP) is the most common vasculitis of childhood and affects the small blood vessels. Pulmonary involvement is a rare complication of HSP and diffuse alveolar hemorrhage (DAH) is the most frequent clinical presentation. Little is known about the real incidence of lung involvement during HSP in the pediatric age and about its diagnosis, management and outcome. Methods In order to discuss the main clinical findings and the diagnosis and management of lung involvement in children with HSP, we performed a review of the literature of the last 40 years. Results We identified 23 pediatric cases of HSP with lung involvement. DAH was the most frequent clinical presentation of the disease. Although it can be identified by chest x-ray (CXR), bronchoalveolar lavage (BAL) is the gold standard for diagnosis. Pulse methylprednisolone is the first-line of therapy in children with DAH. An immunosuppressive regimen consisting of cyclophosphamide or azathioprine plus corticosteroids is required when respiratory failure occurs. Four of the twenty-three patients died, while 18 children had a resolution of the pulmonary involvement. Conclusions DAH is a life-threatening complication of HSP. Prompt diagnosis and adequate treatment are essential in order to achieve the best outcome.


1981 ◽  
Vol 57 (668) ◽  
pp. 390-392 ◽  
Author(s):  
O. Abdel-Hadi ◽  
M. A. Greenstone ◽  
R. B. Hartley ◽  
P. H. Kidner

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