A Case of Severe Lactic Acidosis in Thiamine Deficiency

CHEST Journal ◽  
2014 ◽  
Vol 146 (4) ◽  
pp. 319A
Author(s):  
Herman Dyal ◽  
Juan Fernandez ◽  
Ruchir Patel ◽  
Nena Auraha ◽  
Bruno DiGiovine
Keyword(s):  
Lactic Acidosis ◽  
Thiamine Deficiency ◽  
Severe Lactic Acidosis

scholarly journals Severe lactic acidosis and multiorgan failure due to thiamine deficiency during total parenteral nutrition

2014 ◽  
Vol 2014 (jun03 1) ◽  
pp. bcr2014205264-bcr2014205264 ◽  
Author(s):  
M. Ramsi ◽  
C. Mowbray ◽  
G. Hartman ◽  
N. Pageler
Keyword(s):  
Lactic Acidosis ◽  
Parenteral Nutrition ◽  
Total Parenteral Nutrition ◽  
Thiamine Deficiency ◽  
Multiorgan Failure ◽  
Severe Lactic Acidosis

Severe Lactic Acidosis Related to Acute Thiamine Deficiency

1991 ◽  
Vol 15 (1) ◽  
pp. 105-109 ◽  
Author(s):  
Denis Oriot ◽  
Chantal Wood ◽  
Ronald Gottesman ◽  
Gilbert Huault
Keyword(s):  
Lactic Acidosis ◽  
Thiamine Deficiency ◽  
Severe Lactic Acidosis

scholarly journals Lactic Acidosis in a Congenital Bone Marrow Failure Syndrome

2021 ◽  
pp. 1-4
Author(s):  
Fatima Farid Mir ◽  
Anjan Madasu ◽  
Hani Humad ◽  
Asim Noor Rana
Keyword(s):  
Bone Marrow ◽  
Mitochondrial Dna ◽  
Metabolic Acidosis ◽  
Lactic Acidosis ◽  
Liver Failure ◽  
Bone Marrow Failure ◽  
Disease Course ◽  
Bone Marrow Failure Syndrome ◽  
Severe Lactic Acidosis ◽  
End Stage

Fifteen-month-old male child, known to have a congenital bone marrow failure syndrome, presented in a state of shock with severe lactic acidosis following a brief episode of vomiting. Hospital stay was complicated by recurrent bouts of metabolic acidosis and progressive hepatic failure. Blood mitochondrial DNA sequencing revealed a large heteroplasmic 4,977 bp mitochondrial deletion (approximately 40% of all mitochondrial copies) suggestive of Pearson marrow-pancreas syndrome. By virtue of natural disease course, within a month of admission child succumbed to end-stage liver failure with multi-organ failure and died.

scholarly journals Severe lactic acidosis reversed by thiamine within 24 hours

Critical Care ◽  
2011 ◽  
Vol 15 (6) ◽  
pp. 457 ◽  
Author(s):  
Karin Amrein ◽  
Werner Ribitsch ◽  
Ronald Otto ◽  
Harald C Worm ◽  
Rudolf E Stauber
Keyword(s):  
Lactic Acidosis ◽  
Severe Lactic Acidosis

Lactic acidosis had developed in diabetic patients receiving herbal therapy

MedPharmRes ◽  
2021 ◽  
Vol 5 (2) ◽  
pp. 22-28
Author(s):  
Uyen Vy Doan ◽  
Thanh Thao T. Nguyen ◽  
Thuy An Nguyen ◽  
Van Hoang Lam ◽  
Duong Tien Truong ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Lactic Acidosis ◽  
Glucose Control ◽  
Blood Glucose Control ◽  
Clinical Findings ◽  
Series Data ◽  
Diabetic Patients ◽  
Herbal Products ◽  
Severe Lactic Acidosis ◽  
Two Samples

Introduction: Herbal antidiabetic products are popular in Vietnam. Many cases have presented to hospitals with severe lactic acidosis, shock and were ultimately fatal. We reviewed the clinical findings of these patients for factors that contributed to their illness and death, and analyzed the ingredients contained in these herbal products sold for diabetic treatment. Method: This was a single-center, retrospective, observational case series. Data were collected on all cases who presented with severe lactic acidosis after use of traditional herbal anti-diabetic pills, over the two-year time period 2018 – 2019. Past medical histories and clinical findings were reviewed. Samples of the herbal anti-diabetic products, and patient blood and urine were analyzed. Results: A total of 18 cases of severe lactic acidosis associated with use of herbal anti-diabetic pills were reviewed. These patients had a diagnosis of diabetes for an average of 9 years (9.4 ± 4.6 years). The use of these herbals for blood glucose control ranged from one month to 8 years; approximately 50% of these patients consumed these products over a year’s time. Only two cases had combined herbal products and metformin 500 mg. A total mean of herbal pills consumed was 9 (SD ± 8); patients commonly took combinations of 2 different colored tablets. Major manifestations included gastrointestinal disorders, severe metabolic acidosis (pH = 6.85 ± 0.22, HCO3- = 4.4 ± 2.6), with multi-organ failure and shock on admission. Hyperlactatemia was present in all cases (195 ± 74 mg/dL). For lactate removal and acidosis correction, intermittent hemodialysis or continuous renal replacement therapy was performed, ranging from 2 hours to 72 hours depending on the severity of lactic acidosis and patient need. The mortality rate was 33.3% and all these patients became hypoglycemic, either at initial presentation or during treatment. 22 samples of herbal pills were available for testing that contained the biguanides metformin and phenformin, with a higher concentration of phenformin than metformin if both were present, Phenformin was presented in all samples. Arsenic was found in two samples. Conclusion: Biguanides are an effective treatment for diabetes and were added to traditional herbal pills sold and used for blood glucose control. Many users of these products are doing so because of the cost and perception of the safety of natural remedies. Biguanide poisoning may still occur even in patients without renal impairment.

A Case of Severe Lactic Acidosis Associated with Extreme Mental Stress

2004 ◽  
Vol 57 (6) ◽  
pp. 1354-1355
Author(s):  
Iben Sorgenfrei ◽  
Per Rotboll Nielsen ◽  
J??rgen Viby-Mogensen
Keyword(s):  
Lactic Acidosis ◽  
Mental Stress ◽  
Severe Lactic Acidosis
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