Long-term Outcome of Acute Pulmonary Embolism

CHEST Journal ◽  
2014 ◽  
Vol 145 (3) ◽  
pp. 528A
Author(s):  
Hernando Chávez Roldán ◽  
Jacinto Hernández Borge ◽  
María del Carmen García García ◽  
Pedro Pires Goncalves ◽  
María Teresa Gómez Vizcaíno ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Acute Pulmonary Embolism ◽  
Term Outcome ◽  
Long Term Outcome

Syncope in relation to pulmonary arterial obstructive burden, hemodynamic status and short- and long-term outcome in patients with acute pulmonary embolism

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
B Keskin ◽  
H.C Tokgoz ◽  
O.Y Akbal ◽  
A Hakgor ◽  
S Tanyeri ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Acute Pulmonary Embolism ◽  
Right Atrial ◽  
Term Outcome ◽  
Risk Status ◽  
Long Term Outcome ◽  
Short And Long Term ◽  
Severity Indexes

Abstract Background and aims Although syncope (S) has been reported as one of the presenting findings in patients (pts) with acute pulmonary embolism (APE), its clinical and haemodynamic correlates and impacts on the long-term outcome in this setting remains to be determined. In this single-centre study we evaluated the clinical and haemodynamic significance of S in APE in initial asessment, and during short- and long-term follow-up period. Methods Our study was based on the retrospective and prospective analysis of the overall 641 pts (age 65 (51–74 IQR) yrs, 56.2% female) with diagnosis of documented APE who underwent anticoagulant (n=207), thrombolytic (n=164), utrasound-facilitated thrombolysis (UFT) (n=218) or rheolytic thrombectomy (RT) (n=52). The systematic work- up including multidetector computed tomography (MDCT), Echo, biomarkers, and PE severity indexes were performed in all pts, and Qanadli score (QS) was used as the measure of the thrombotic burden in the pulmonary arteries (PA). Results The S as the presenting symptom In 30.2% of pts with APE. At baseline assessment, S(+) vs S(−) APE subgroups had a significantly shorter symptom-diagnosis interval, a higher risk status according to the significant elevations in troponin T, D-dimer, the higher PE severity indexes, a more deteriorated right ventricle/left ventricle ratio (RV/LV r), right atrial/left atrial ratio (LA/RAr) and RV longitudinal function indexes including tricuspid annular planary excursion (TAPSE) and tissue velocity (St), a significantly higher PA obstructive burden as assessed by QS and PA pressures. Thrombolytic therapy (36.2% vs 21%, p<0.001) and RT (11.9% vs 6.47%, p=0.037) were more frequently utilized S(+) as compared to S(−) group. However, all these differences between two subgroups were found to disappear after evidence-based APE treatments. In-hospital mortality (IHM) (12.95% vs 6%, p=0.007) and minor bleeding (10.36% vs 2.9%, p<0.001) were significantly higher in S(+) pts as compared to those in S(−) subgroup. Binominal logistic regression analysis revealed that PESI score and RV/LVr independently associated with S while IHM was only predicted by age and heart rate. The COX proportional hazard method showed that RV/LVr at discharge and malignancy were independently associated with cumulative mortality during follow-up duration of 620 (200–1170 IQ) days. Conclusions The presence of S in pts with APE was found to be asociated with a higher PA obstructive burden, a more deteriorated RV function and haemodynamics and higher risk status which may need more agressive reperfusion treatments. However, in the presence of the optimal treatments, S did not predict neither in-hospital outcome, nor long-term mortality. Funding Acknowledgement Type of funding source: None

Long-term outcome of patients with persistent vascular obstruction on computed tomography pulmonary angiography 6 months after acute pulmonary embolism

2012 ◽  
Vol 53 (7) ◽  
pp. 728-731 ◽  
Author(s):  
Rafael Golpe ◽  
Luis A Pérez de Llano ◽  
Olalla Castro-Añón ◽  
Manuel Vázquez-Caruncho ◽  
Carlos González-Juanatey ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Pulmonary Embolism ◽  
Acute Pulmonary Embolism ◽  
Pulmonary Angiography ◽  
Computed Tomography Pulmonary Angiography ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Vascular Obstruction

Lipocalin-2 Predicts Long-Term Outcome of Normotensive Patients with Acute Pulmonary Embolism

2019 ◽  
Vol 20 (2) ◽  
pp. 101-110
Author(s):  
Haixu Yu ◽  
Zhuohui Liu ◽  
Jie Lu ◽  
Xinying Yang ◽  
Xin-Xin Yan ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Acute Pulmonary Embolism ◽  
Lipocalin 2 ◽  
Term Outcome ◽  
Long Term Outcome

scholarly journals Short- and Long-Term Outcome after Surgical Therapy in Acute Pulmonary Embolism

2018 ◽  
Vol 66 (S 01) ◽  
pp. S1-S110
Author(s):  
K. Dohle ◽  
D. Dohle ◽  
R. Chaban ◽  
I. Halbroth ◽  
A. Beiras-Fernandez ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Surgical Therapy ◽  
Acute Pulmonary Embolism ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Short And Long Term

scholarly journals A Comparison of GFR Calculated by Cockcroft-Gault vs. MDRD Formula in the Prognostic Assessment of Patients with Acute Pulmonary Embolism

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Magdalena Pływaczewska ◽  
David Jiménez ◽  
Mareike Lankeit ◽  
Piotr Pruszczyk ◽  
Maciej Kostrubiec
Keyword(s):  
Pulmonary Embolism ◽  
Acute Pulmonary Embolism ◽  
Primary Outcome ◽  
Roc Curves ◽  
The Elderly ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Prognostic Assessment ◽  
Hospitalised Patients

Introduction. Risk stratification is mandatory for optimal management of patients with acute pulmonary embolism (APE). Previous studies indicated that renal dysfunction predicts outcome and can improve risk assessment in APE. Aim. The aim of the study was a comparison of estimated glomerular filtration rate (eGFR) formulas, MDRD, and Cockcroft-Gault (CG), in the prognostic assessment of patients with APE. Materials and Methods. Data from 2274 (1147 M/1127 F, median 71 years) hospitalised patients with APE prospectively included in a multicenter, observational, cohort study were analysed. A serum creatinine measurement as a routine laboratory parameter at the cooperating centers and eGFR calculation were performed on admission. Patients were followed for 180 days. The primary outcome was death from any cause within 30 days. Results. The eGFR levels assessed by both, MDRD (eGFRMDRD) and CG formula (eGFRCG), were highest in patients with low-risk APE and lowest in high-risk APE. The eGFR (using both methods) was significantly lower in nonsurvivors compared to survivors. Using a threshold of <60 ml/min/1.73 m2, eGFRMDRD revealed the primary outcome with sensitivity 67%, specificity 52%, PPV 8%, and NPV 97%, while eGFRCG had a sensitivity 62%, specificity 62%, PPV 8.6%, and NPV 96%. The area under the ROC curve for eGFRCG tended to be higher than that for eGFRMDRD: 0.658 (95% CI: 0.608-0.709) vs. 0.631 (95% CI: 0.578-0.683), p = 0.12 . A subanalysis of ROC curves in a population above 65 yrs showed a higher AUC for eGFRCG than based on MDRD. Kaplan-Meier analysis showed a worse long-term outcome in patients with impaired renal function. Conclusion. eGFRMDRD and eGFRCG assessed on admission significant short- and long-term mortality predictors in patients with APE. The eGFRCG seems to be a slightly better 30-day mortality predictor than eGFRMDRD in the elderly.

Long-term outcome of pulmonary embolism

Therapy ◽  
2008 ◽  
Vol 5 (2) ◽  
pp. 159-167
Author(s):  
Guy Meyer ◽  
Benjamin Planquette ◽  
Olivier Sanchez
Keyword(s):  
Pulmonary Embolism ◽  
Term Outcome ◽  
Long Term Outcome

scholarly journals Long-Term Outcome of Thrombolytic Therapy for Massive Pulmonary Embolism in Pregnancy

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Sy Van Hoang ◽  
Anh Tuan Vo ◽  
Kha Minh Nguyen
Keyword(s):  
Pulmonary Embolism ◽  
Pregnant Woman ◽  
Massive Pulmonary Embolism ◽  
Fibrinolytic Therapy ◽  
Shortness Of Breath ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Fetal Complications ◽  
In Pregnancy

A 25-year-old pregnant woman presented at 12 weeks of gestation with syncope and shortness of breath caused by massive pulmonary embolism. Due to persistent shock, fibrinolytic therapy with rtPA was administered. After fibrinolysis, clinical and hemodynamic response was excellent. No bleeding and fetal complications were recorded.

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