Low Socioeconomic Status Is a Risk Factor for Cardiovascular Disease Among Adult Obstructive Sleep Apnea Syndrome Patients Requiring Treatment

CHEST Journal ◽  
2006 ◽  
Vol 130 (3) ◽  
pp. 766-773 ◽  
Author(s):  
Ariel Tarasiuk ◽  
Sari Greenberg-Dotan ◽  
Tzahit Simon ◽  
Asher Tal ◽  
Arie Oksenberg ◽  
...  
2007 ◽  
Vol 293 (4) ◽  
pp. R1666-R1670 ◽  
Author(s):  
Walter T. McNicholas

Considerable evidence is now available of an independent association between obstructive sleep apnea syndrome (OSAS) and cardiovascular disease. The association is particularly strong for systemic arterial hypertension, but there is growing evidence of an association with ischemic heart disease and stroke. The mechanisms underlying cardiovascular disease in patients with OSAS are still poorly understood. However, the pathogenesis is likely to be a multifactorial process involving a diverse range of mechanisms, including sympathetic overactivity, selective activation of inflammatory molecular pathways, endothelial dysfunction, abnormal coagulation, and metabolic dysregulation, the latter particularly involving insulin resistance and disordered lipid metabolism. Therapy with continuous positive airway pressure (CPAP) has been associated with significant benefits to cardiovascular morbidity and mortality, both in short-term studies addressing specific aspects of morbidity, such as hypertension, and more recently in long-term studies that have evaluated major outcomes of cardiovascular morbidity and mortality. However, there is a clear need for further studies evaluating the impact of CPAP therapy on cardiovascular outcomes. Furthermore, studies on the impact of CPAP therapy have provided useful information concerning the role of basic cell and molecular mechanisms in the pathophysiology of OSAS.


2011 ◽  
Vol 16 (2) ◽  
pp. 413-417 ◽  
Author(s):  
Manuele Casale ◽  
Emanuela Vesperini ◽  
Massimiliano Potena ◽  
Marco Pappacena ◽  
Federica Bressi ◽  
...  

Author(s):  
A. L. Kalinkin

The obstructive sleep apnea syndrome (OSAS) is a risk factor for cardiovascular diseases The results of epidemiological, observational, and experimental studies support the fact that OSAS is of considerable importance in the development of arterial hypertension via chronic sympathetic activation and sleep-induced neurohumoral changes OSAS is of prime importance in the development of refractory AH CPAP therapy not only eliminates sleep-induced obstructive respiratory impairments, but frequently lowers blood pressure in hypertensive patients, and improves the prognosis of cardiovascular diseases


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