scholarly journals Urinary Albumin-Creatinine Ratio, Estimated Glomerular Filtration Rate, and All-Cause Mortality Among US Adults With Obstructive Lung Function

CHEST Journal ◽  
2015 ◽  
Vol 147 (1) ◽  
pp. 56-67 ◽  
Author(s):  
Earl S. Ford
Keyword(s):  
Glomerular Filtration Rate ◽  
Lung Function ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Urinary Albumin ◽  
Creatinine Ratio ◽  
Albumin Creatinine Ratio ◽  
All Cause Mortality

scholarly journals Meta-analyses identify DNA methylation associated with kidney function and damage

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Pascal Schlosser ◽  
Adrienne Tin ◽  
Pamela R. Matias-Garcia ◽  
Chris H. L. Thio ◽  
Roby Joehanes ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Dna Methylation ◽  
Glomerular Filtration Rate ◽  
Kidney Disease ◽  
Glomerular Filtration ◽  
Kidney Function ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Urinary Albumin ◽  
Creatinine Ratio

AbstractChronic kidney disease is a major public health burden. Elevated urinary albumin-to-creatinine ratio is a measure of kidney damage, and used to diagnose and stage chronic kidney disease. To extend the knowledge on regulatory mechanisms related to kidney function and disease, we conducted a blood-based epigenome-wide association study for estimated glomerular filtration rate (n = 33,605) and urinary albumin-to-creatinine ratio (n = 15,068) and detected 69 and seven CpG sites where DNA methylation was associated with the respective trait. The majority of these findings showed directionally consistent associations with the respective clinical outcomes chronic kidney disease and moderately increased albuminuria. Associations of DNA methylation with kidney function, such as CpGs at JAZF1, PELI1 and CHD2 were validated in kidney tissue. Methylation at PHRF1, LDB2, CSRNP1 and IRF5 indicated causal effects on kidney function. Enrichment analyses revealed pathways related to hemostasis and blood cell migration for estimated glomerular filtration rate, and immune cell activation and response for urinary albumin-to-creatinineratio-associated CpGs.

scholarly journals Change in the estimated glomerular filtration rate over time and risk of all-cause mortality

2013 ◽  
Vol 83 (4) ◽  
pp. 684-691 ◽  
Author(s):  
Tanvir C. Turin ◽  
Josef Coresh ◽  
Marcello Tonelli ◽  
Paul E. Stevens ◽  
Paul E. de Jong ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
All Cause Mortality ◽  
Over Time
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