scholarly journals Impact of Respiratory Symptoms and Pulmonary Function on Quality of Life of Long-term Survivors of Non-Small Cell Lung Cancer

CHEST Journal ◽  
2004 ◽  
Vol 125 (2) ◽  
pp. 439-445 ◽  
Author(s):  
Linda Sarna ◽  
Lorraine Evangelista ◽  
Donald Tashkin ◽  
Geraldine Padilla ◽  
Carmack Holmes ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Lung Cancer ◽  
Pulmonary Function ◽  
Small Cell Lung Cancer ◽  
Respiratory Symptoms ◽  
Small Cell ◽  
Small Cell Lung ◽  
Long Term Survivors

Quality of Life of Long-Term Survivors of Non–Small-Cell Lung Cancer

2002 ◽  
Vol 20 (13) ◽  
pp. 2920-2929 ◽  
Author(s):  
Linda Sarna ◽  
Geraldine Padilla ◽  
Carmack Holmes ◽  
Donald Tashkin ◽  
Mary Lynn Brecht ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Lung Cancer ◽  
Pulmonary Function ◽  
Small Cell ◽  
Living Alone ◽  
Small Cell Lung ◽  
Sf 36 ◽  
Long Term Survivors

PURPOSE: To describe the quality of life (QOL) among survivors of non–small-cell lung cancer (NSCLC).PATIENTS AND METHODS: One hundred forty-two 5-year minimum self-reported disease-free survivors of NSCLC completed QOL instruments (QOL-Survivor and Medical Outcomes Study 36-Item Short Form [SF-36]) and assessments of emotional distress (Center for Epidemiologic Studies Depression Scale [CES-D]), comorbid disease, and tobacco use. Pulmonary function was assessed with a hand-held spirometer. Multivariate regression methods were used on total QOL-Survivor scores and physical (PC) and mental (MC) component scores of the SF-36.RESULTS: The majority (71%) of survivors described themselves as hopeful, and 50% viewed the cancer experience as contributing to positive life changes (QOL-Survivor). Comorbidity was common (60% ≥ one condition); 22% had distressed mood (CES-D ≥ 16). Most were former smokers (76%); 13% continued to smoke. Half had moderate/severe pulmonary distress (forced expired volume in 1 second [FEV1] < 70% of predicted). Regression models including the set of variables (age, sex, living alone, education, smoking status, pulmonary function category, distressed mood, time since diagnosis, and comorbidity) accounted for 37%, 48%, and 29% in the QOL-total, MC, and PC scores, respectively. Primary predictors of lower QOL scores were white ethnicity and distressed mood (CES-D ≥ 16) (34% of the variance explained). The primary predictor of lower MC scores was distressed mood (R2= 0.45). Lower PC scores were associated with older age, living alone, FEV1less than 70% of predicted, distressed mood, time since diagnosis, and more comorbid diseases (R2= 0.28).CONCLUSION: These findings provide the first description of the QOL of long-term survivors of lung cancer. Risk factors for poorer QOL are strongly linked to distressed mood, which is a potential target for intervention.

scholarly journals P1.08-036 Thoracotomy and VATS-Surgery in Local Non-Small Cell Lung Cancer: Differences in Long-Term Health Related Quality of Life

2017 ◽  
Vol 12 (1) ◽  
pp. S752-S753
Author(s):  
Ville Rauma ◽  
Saana Andersson ◽  
Jari Räsänen ◽  
Harri Sintonen ◽  
Jarmo Salo ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Small Cell ◽  
Health Related Quality ◽  
Small Cell Lung ◽  
Related Quality ◽  
Health Related

scholarly journals Quality of Life Supersedes the Classic Prognosticators for Long-Term Survival in Locally Advanced Non–Small-Cell Lung Cancer: An Analysis of RTOG 9801

2009 ◽  
Vol 27 (34) ◽  
pp. 5816-5822 ◽  
Author(s):  
Benjamin Movsas ◽  
Jennifer Moughan ◽  
Linda Sarna ◽  
Corey Langer ◽  
Maria Werner-Wasik ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Lung Cancer ◽  
Prognostic Factors ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Locally Advanced ◽  
Small Cell ◽  
Small Cell Lung

Purpose To determine the added value of quality of life (QOL) as a prognostic factor for overall survival (OS) in patients with locally advanced non–small-cell lung cancer (NSCLC) treated on Radiation Therapy Oncology Group RTOG-9801. Patients and Methods Two hundred forty-three patients with stage II/IIIAB NSCLC received induction paclitaxel and carboplatin (PC) and then concurrent weekly PC and hyperfractionated radiation (to 69.6 Gy). Patients were randomly assigned to amifostine (AM) or no AM during chemoradiotherapy. The following pretreatment factors were analyzed as prognostic factors for OS: Karnofsky performance status, stage, sex, age, race, marital status, histology, tumor location, hemoglobin, tobacco use, treatment arm (AM v no AM) and QOL scores (European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire C30 [QLQ-C30] and Lung Cancer 13 [LC-13]). A multivariate (MVA) Cox proportional hazards model was performed using a backwards selection process. Results Of the 239 analyzable patients, 91% had a baseline global QOL score. Median follow-up time was 59 months for patients still alive and 17 months for all patients. Median baseline QLQ-C30 global QOL score was 66.7 on both treatment arms. Whether the global QOL score was treated as a dichotomized variable (based on the median score) or a continuous variable, all other variables fell out of the MVA for OS. Patients with a global QOL score less than 66.7 had an approximately 70% higher rate of death than patients with scores ≥ 66.7 (P = .004). A 10-point higher baseline global QOL score corresponded to a decrease in the hazard of death by approximately 10% (P = .004). The other independent QOL predictors for OS were the QLQ-C30 physical functioning (P = .011) and LC-13 dyspnea scores (P = .012). Conclusion In this analysis, baseline global QOL score replaced known prognostic factors as the sole predictor of long-term OS for patients with locally advanced NSCLC.

scholarly journals Thoracotomy and VATS Surgery in Local Non–Small-Cell Lung Cancer: Differences in Long-Term Health-Related Quality Of Life

2019 ◽  
Vol 20 (5) ◽  
pp. 378-383 ◽  
Author(s):  
Ville Rauma ◽  
Saana Andersson ◽  
Eric M. Robinson ◽  
Jari V. Räsänen ◽  
Harri Sintonen ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Small Cell ◽  
Health Related Quality ◽  
Small Cell Lung ◽  
Related Quality ◽  
Health Related

The Extent of Lung Parenchyma Resection Significantly Impacts Long-Term Quality of Life in Patients With Non-Small Cell Lung Cancer

CHEST Journal ◽  
2009 ◽  
Vol 135 (2) ◽  
pp. 322-329 ◽  
Author(s):  
Tobias Schulte ◽  
Bodo Schniewind ◽  
Peter Dohrmann ◽  
Thomas Küchler ◽  
Roland Kurdow
Keyword(s):  
Quality Of Life ◽  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Lung Parenchyma ◽  
Small Cell ◽  
Small Cell Lung
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