Evaluation of Myocardial Injury Following Repeated Internal Atrial Shocks by Monitoring Serum Cardiac Troponin I Levels

CHEST Journal ◽  
2000 ◽  
Vol 118 (2) ◽  
pp. 342-347 ◽  
Author(s):  
Giuseppe Boriani ◽  
Mauro Biffi ◽  
Vittorio Cervi ◽  
Gabriele Bronzetti ◽  
Giorgia Magagnoli ◽  
...  
Keyword(s):  
Cardiac Troponin ◽  
Myocardial Injury ◽  
Troponin I ◽  
Cardiac Troponin I ◽  
Serum Cardiac Troponin

scholarly journals Improved detection of minor ischemic myocardial injury with measurement of serum cardiac troponin I

1997 ◽  
Vol 43 (11) ◽  
pp. 2047-2051 ◽  
Author(s):  
Fred S Apple ◽  
Alireza Falahati ◽  
Pamela R Paulsen ◽  
Elizabeth A Miller ◽  
Scott W Sharkey
Keyword(s):  
Cardiac Troponin ◽  
Myocardial Injury ◽  
Troponin I ◽  
Cardiac Troponin I ◽  
Clinical Sensitivity ◽  
Reference Limit ◽  
Normal Limits ◽  
Serial Serum ◽  
Upper Reference Limit ◽  
Serum Cardiac Troponin

Abstract This study compared the diagnostic accuracy of the measurement of serum cardiac troponin I (cTnI) with creatine kinase (CK) MB mass in patients with minor myocardial injury whose measured total CK activity did not exceed twice the upper reference limit (300 U/L for men; 200 U/L for women). Forty-eight consecutive patients presenting with chest pain and with in-hospital documentation of myocardial injury were enrolled. Electrocardiogram, echocardiogram, and serial serum CK-MB mass, cTnI, and total CK were measured over 36 h after admission. Peak total CK activity was within normal limits in 28 patients (58%). The mean (±SD) peak CK-MB mass and cTnI concentrations were: 16.4 (11.8) μg/L and 132 (13.0) μg/L; respectively. The peak biochemical marker index (defined as CK-MB or cTnI divided by its respective upper reference limit) was significantly (P <0.05) higher for cTnI than for CK-MB from 7 to 36 h. The clinical sensitivity for detection of myocardial injury for cTnI was 100% [95% confidence interval (CI): 87.2% to 100%], compared with 81.8% (CI: 67.3% to 91.8%) for CK-MB. Thus, cTnI was more sensitive than CK-MB mass for detection of myocardial injury in patients with small increases of total CK.

Release kinetics of serum cardiac troponin i in ischemic myocardial injury

1996 ◽  
Vol 29 (6) ◽  
pp. 587-594 ◽  
Author(s):  
Jean-Pierre Bertinchant ◽  
Catherine Larue ◽  
Isabelle Pernel ◽  
Bertrand Ledermann ◽  
Pascale Fabbro-Peray ◽  
...  
Keyword(s):  
Cardiac Troponin ◽  
Myocardial Injury ◽  
Troponin I ◽  
Release Kinetics ◽  
Cardiac Troponin I ◽  
Serum Cardiac Troponin ◽  
Kinetics Of

scholarly journals Elevated serum homocysteine level has a positive correlation with serum cardiac troponin I in patients with acute myocardial infarction

2012 ◽  
Vol 38 (1) ◽  
pp. 9-13 ◽  
Author(s):  
N Alam ◽  
HILR Khan ◽  
AW Chowdhury ◽  
MS Haque ◽  
MS Ali ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Cardiac Troponin ◽  
Myocardial Injury ◽  
Troponin I ◽  
Homocysteine Level ◽  
Surrogate Marker ◽  
Cardiac Troponin I ◽  
Serum Homocysteine ◽  
Serum Cardiac Troponin

The objective of the present study is to find out whether the increased serum homocysteine level is associated with the increased serum troponin I as a surrogate marker of extent of myocardial injury in acute myocardial infarction patients. Elevated homocysteine levels are associated with increased thrombosis. In patients presenting with Acute Coronary Syndrome (ACS), it is not known whether this association is reflected in the degree of myocardial injury. This was a cross sectional study conducted among the patients with acute myocardial infarction in the Department of Cardiology, Dhaka Medical College Hospital during the period of October 2009 to September 2010 and which included 194 consecutive patients with acute myocardial infarction. The mean (±SD) serum homocysteine level was 20.2±14.3 ?mol/L with range from 7.4 to 129.1 ?mol/L. Mean serum troponin-I level was classified according to normal (<15?mol/L) and high (?15?mol/L) levels of serum homocysteine values. The mean serum troponin-I level was 8.9±8.6 ng/ml in the patients having normal serum homocysteine level and 18.4±6.5 ng/ml in the patients having high serum homocysteine level. A significant positive correlation (r=0.273; p<0.001) was found between serum troponin-I level with homocysteine level. Patients with moderate hyperhomocysteinemia (?15 ?mol/L) was found to be 7.09 times more likely to have increased serum troponin-I (a surrogate marker of extent of myocardial injury). The main observation of the present study was that elevated serum homocysteine level has a positive correlation with serum cardiac troponin-I in patients with acute myocardial infarction. So serum homocysteine is associated with increased extent of myocardial injury as measured by serum cardiac troponin-I level, a surrogate marker in patients with acute myocardial infarction.  DOI: http://dx.doi.org/10.3329/bmrcb.v38i1.10445  Bangladesh Med Res Counc Bull 2012; 38: 9-13

scholarly journals A Comparative Study Between Conventional and Direct Stenting by Measuring Serum Cardiac Troponin-I

2012 ◽  
Vol 7 (1) ◽  
pp. 23-27
Author(s):  
Syeda Fahmida Afrin ◽  
Md Hasanur Rahman ◽  
Syed Dawoo Md Taimur ◽  
Muhsina Abdullah ◽  
Safia Sharmin ◽  
...  
Keyword(s):  
Cardiac Troponin ◽  
Myocardial Injury ◽  
Troponin I ◽  
Coronary Intervention ◽  
Cardiac Troponin I ◽  
Direct Stenting ◽  
Percutaneous Coronary ◽  
The Mean ◽  
The Difference ◽  
Serum Cardiac Troponin

The aim of the study is to assess serum Cardiac Troponin-I level in patients who have underdone Percutaneous coronary intervention (PCI) as an indication of myocardial injury and. Compare the troponin-I level in direct or conventional stetting in PCI and assess the superiorty of two methods of PCI, regarding myocardial injury and outcome. Cardiac Troponin-I (cTnI) is known to have the highest specificity & analytic sensitivity for detection of myocardial injury. This study was aimed to compare between conventional and direct stenting by assessing of serum cTnI. This observentional study was carried out in the Deparment of Biochemistry, Dhaka Medical College & Dept. of Cardiology, Ibrahim Cardiac Hospital and Research Institute during the period from July 2007 to June 2008. In this study we enrolled 60 diagnosed cases of coronary heart disease patients which were grouped as direct stenting (30 patients) and conventional stenting (30 patients) group. In this study, the age of the patients ranged from 42-72 years with a mean of 56.7 (±7.1) years. Male and female participants were 44 and 16 respectively. The mean left ventricular ejection fraction of them were 55.43 (±7.9) %. The difference of the mean troponin-I level before direct and conventional stenting was similar. Although the mean level of troponin-I after conventional stenting was higher (0.081± 0.042) than that of direct stenting (0.066±0.042), the difference of means was not statically significant (P> 0.05). Significant difference was observed between the mean before and after direct stenting as well as conventional stenting. From our observation we can conclude that serum cTnI level was higher after conventional stenting than that of direct stenting but the difference of means was not statically significant. It rises significantly after Percutaneous coronary intervention regardless of the type of procedure, whether direct or conventional stenting. Though the clinical outcome is reported to be similar in direct and conventional stenting, the direct stenting requires less procedural and equipment cost as well as less exposure time to radiation. DOI: http://dx.doi.org/10.3329/uhj.v7i1.10206 UHJ 2011; 7(1): 23-27

Sex-based differences in serum cardiac troponin I, a specific marker for myocardial injury, after cardiac surgery

2003 ◽  
Vol 31 (3) ◽  
pp. 689-693 ◽  
Author(s):  
J. C. Schwarzenberger ◽  
Lena S. Sun ◽  
M. A. Pesce ◽  
E. J. Heyer ◽  
E. Delphin ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Cardiac Troponin ◽  
Myocardial Injury ◽  
Troponin I ◽  
Cardiac Troponin I ◽  
Specific Marker ◽  
Serum Cardiac Troponin

scholarly journals Misclassification of Myocardial Injury by a High-Sensitivity Cardiac Troponin I Assay

2021 ◽  
Author(s):  
Peter A. Kavsak ◽  
Shawn Mondoux ◽  
Andrew Worster ◽  
Janet Martin ◽  
Vikas Tandon ◽  
...  
Keyword(s):  
Cardiac Troponin ◽  
Myocardial Injury ◽  
Troponin I ◽  
High Sensitivity ◽  
Cardiac Troponin I

Elevations of Troponin I after interventional cardiac catheterization

2001 ◽  
Vol 11 (4) ◽  
pp. 375-378 ◽  
Author(s):  
Prince J. Kannankeril ◽  
David F. Wax ◽  
Elfriede Pahl
Keyword(s):  
Cardiac Catheterization ◽  
Cardiac Troponin ◽  
Baseline Level ◽  
Myocardial Injury ◽  
Troponin I ◽  
Cardiac Troponin I ◽  
Specific Marker ◽  
Before And After ◽  
Baseline Sample

Background: Elevation of cardiac troponin I in the serum is a specific marker for myocardial injury. We measured levels of troponin I in the serum in children before and after cardiac catheterization to determine if this procedure was associated with an increase in levels of troponin. Methods: We enrolled patients under 21 years of age undergoing cardiac catheterization at our institution. A baseline sample of serum was drawn at the start of the procedure. Repeat samples were obtained immediately after, and six hours subsequent to the procedure. All samples were analyzed for cardiac troponin I using the Abbott AxSYM microparticle immunoassay system. Levels were considered normal (0–0.4 ng/ml) or elevated (>0.4ng/ml). Patients were excluded if the baseline level was elevated. Results: Levels of cardiac troponin I were elevated in the serum from 11 of 14 (79%) cases immediately after the procedure (p < 0.0001), and in 12 of 14 (86%) six hours later (p < 0.0001). Only 2 patients had recognized complications potentially causing myocardial injury. Conclusion: Levels of cardiac troponin I increase in the serum in a high proportion of children after cardiac catheterization. These elevations can be observed immediately, and are maintained for at least six hours. Our study suggests that cardiac catheterization, predominantly intervention, is associated with myocardial injury, even in the absence of complications.

Assessment of left ventricular function using serum cardiac troponin I measurements following myocardial infarction

1998 ◽  
Vol 272 (1) ◽  
pp. 59-67 ◽  
Author(s):  
Fred S. Apple ◽  
Scott W. Sharkey ◽  
Alireza Falahati ◽  
Maryann Murakami ◽  
Naheed Mitha ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Left Ventricular Function ◽  
Ventricular Function ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Left Ventricular ◽  
Cardiac Troponin I ◽  
Serum Cardiac Troponin
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