Troponin I, Troponin T, or Creatine Kinase-MB to Detect Perioperative Myocardial Damage After Coronary Artery Bypass Surgery

CHEST Journal ◽  
1998 ◽  
Vol 114 (2) ◽  
pp. 482-486 ◽  
Author(s):  
Eric Bonnefoy ◽  
Sylvie Filley ◽  
Gilbert Kirkorian ◽  
Jeannine Guidollet ◽  
Ricardo Roriz ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Coronary Artery ◽  
Coronary Artery Bypass ◽  
Coronary Artery Bypass Surgery ◽  
Bypass Surgery ◽  
Troponin I ◽  
Troponin T ◽  
Artery Bypass ◽  
Myocardial Damage ◽  
Creatine Kinase Mb

Leucocyte-depleted cardioplegia does not reduce reperfusion injury in hypothermic coronary artery bypass surgery

Perfusion ◽  
1999 ◽  
Vol 14 (5) ◽  
pp. 371-377 ◽  
Author(s):  
P G Browning ◽  
M Pullan ◽  
M Jackson ◽  
A Rashid
Keyword(s):  
Oxidative Stress ◽  
Coronary Artery ◽  
Coronary Artery Bypass ◽  
Coronary Artery Bypass Surgery ◽  
Myocardial Injury ◽  
Bypass Surgery ◽  
Troponin T ◽  
Artery Bypass ◽  
Oxidized Glutathione ◽  
Patient Groups

This study investigated the effects of leucocyte-depleted cardioplegia on postreperfusion oxidative stress and myocardial injury in elective hypothermic coronary artery bypass surgery. Forty patients were randomized to receive either cardioplegia with leucocytes depleted by an in-line Pall BC1B filter, or blood cardioplegia without leucocyte depletion. Transmyocardial oxidative stress was assessed by oxidized glutathione measurements in samples taken simultaneously from the coronary sinus and aortic root, and myocardial injury by postoperative CKMB and troponin-T measurements. The BC1B filters reduced numbers of cardioplegia leucocytes by a mean of 90.7%. Both patient groups demonstrated significant increases ( p < 0.001) in transcardiac oxidized glutathione gradients after crossclamp release. No significant differences were found between the groups for postreperfusion oxidized glutathione gradients, postoperative levels of CKMB or troponin-T, or in the frequency of perioperative and postoperative complications. These results suggest that leucocyte-depleted cardioplegia does not significantly improve myocardial protection in patients undergoing elective coronary artery bypass surgery.

scholarly journals Relation of creatine kinase isoenzyme MB to postoperative electrocardiographic diagnosis in patients undergoing coronary-artery bypass surgery.

1979 ◽  
Vol 25 (1) ◽  
pp. 93-98 ◽  
Author(s):  
C R Roe ◽  
G S Wagner ◽  
W G Young ◽  
S E Curtis ◽  
F R Cobb ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Coronary Artery ◽  
Coronary Artery Bypass ◽  
Coronary Artery Bypass Surgery ◽  
Bypass Surgery ◽  
Artery Bypass ◽  
Myocardial Necrosis ◽  
Early Postoperative Period ◽  
Daily Sampling ◽  
Electrocardiographic Changes

Abstract We compared (a) the frequency of detection of isoenzyme MB of creatine kinase (CK; EC 2.7.3.2) in serum of patients undergoing coronary-artery bypass surgery, (b) the interval during uhich its activity was supranormal in serum, and (c) an index of the amount of CK released into blood ("CK-MB area") with postoperative electrocardiographic changes in 80 patients. The frequency of detection of CK-MB is a function of frequency of sampling during the early postoperative period. Because the duration of appearance and the calculated CK-MB area increased as the electrocardiogram became more specific for infarction (p less than 0.01), a twice-daily sampling schedule proved clinically relevant. Only 5.4% of patients had electrocardiographic evidence of infarction when CK-MB was absent by the second postoperative morning. When CK-MB was still detected at that time, 69.6% of patients had persistent new Q waves, consistent with infarction. In three patients who died postoperatively, significant myocardial necrosis was demonstrated. All three had had persistently increased values for CK-MB, related to electrocardiographic changes of infarction in one patient and ischemic changes in two. Evidently CK-MB is a more sensitive indicator of myocardial necrosis than the electrocardiogram and CK-MB area should be a useful criterion in evaluating methods of intra-operative myocardial protection.

Soluble Adhesion Molecules in Coronary Artery Bypass Surgery

2003 ◽  
Vol 11 (3) ◽  
pp. 198-202 ◽  
Author(s):  
Minxin Wei ◽  
Jari Laurikka ◽  
Pekka Kuukasjärvi ◽  
Erkki Pehkonen ◽  
Matti Tarkka
Keyword(s):  
Cardiopulmonary Bypass ◽  
Coronary Artery ◽  
Adhesion Molecules ◽  
Coronary Artery Bypass ◽  
Plasma Levels ◽  
Coronary Artery Bypass Surgery ◽  
Bypass Surgery ◽  
Artery Bypass ◽  
Soluble Adhesion Molecules ◽  
Creatine Kinase Mb

Plasma levels of sE-selectin, sP-selectin, and sICAM-1 were measured before anesthesia and at 0.5, 4, and 20 hours after cardiopulmonary bypass in 37 men undergoing coronary artery bypass surgery. Plasma sE-selectin remained close to the preoperative levels. The levels of sP-selectin increased significantly from 46.5 ± 15.3 ng·mL−1 to 69.3 ± 39.6 ng·mL−1 at 0.5 hours, 84.1 ± 45.5 ng·mL−1 at 4 hours, and 79.6 ± 35.5 ng·mL−1 at 20 hours. Plasma sICAM-1 levels decreased 0.5 hours after cardiopulmonary bypass, recovered at 4 hours, and showed a significant increase at 20 hours. The changes in plasma levels of adhesion molecules did not correlate with the duration of bypass or aortic crossclamping, hemodynamics, or creatine kinase-MB levels. However, sE-selectin and sICAM-1 levels increased considerably more in patients who needed norepinephrine in the intensive care unit. These results indicate that the transient changes in plasma levels of soluble adhesion molecules are not associated with postoperative myocardial injury in low-risk coronary grafting, although they correlate with the need for a vasopressor.

scholarly journals Ischaemic preconditioning reduces troponin T release in patients undergoing coronary artery bypass surgery.

Heart ◽  
1997 ◽  
Vol 77 (4) ◽  
pp. 314-318 ◽  
Author(s):  
D. P. Jenkins ◽  
W. B. Pugsley ◽  
A. M. Alkhulaifi ◽  
M. Kemp ◽  
J. Hooper ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Coronary Artery Bypass ◽  
Coronary Artery Bypass Surgery ◽  
Bypass Surgery ◽  
Troponin T ◽  
Artery Bypass ◽  
Ischaemic Preconditioning
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