scholarly journals The Effect of Imatinib and Nilotinib on Airway Smooth Muscle Thickening in Murine Model of Chronic Asthm

CHEST Journal ◽  
2011 ◽  
Vol 140 (4) ◽  
pp. 234A
Author(s):  
HyoungKyu Yoon ◽  
Chin Rhee
Keyword(s):  
Smooth Muscle ◽  
Airway Smooth Muscle ◽  
Murine Model

Hypertrophic Airway Smooth Muscle Mass Correlates with Increased Airway Responsiveness in a Murine Model of Asthma

2012 ◽  
Vol 46 (4) ◽  
pp. 532-540 ◽  
Author(s):  
Pamela J. Plant ◽  
Michelle L. North ◽  
Andrew Ward ◽  
Michael Ward ◽  
Nivedita Khanna ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Muscle Mass ◽  
Airway Smooth Muscle ◽  
Murine Model ◽  
Airway Responsiveness

Inhaled corticosteroid prevents the thickening of airway smooth muscle in murine model of chronic asthma

2008 ◽  
Vol 21 (1) ◽  
pp. 14-19 ◽  
Author(s):  
Sook Young Lee ◽  
Jin Sook Kim ◽  
Jung Mi Lee ◽  
Soon Seok Kwon ◽  
Kwan Hyung Kim ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Airway Smooth Muscle ◽  
Murine Model ◽  
Chronic Asthma ◽  
Inhaled Corticosteroid

scholarly journals Soluble Guanylyl Cyclase is Reduced in Airway Smooth Muscle Cells From a Murine Model of Allergic Asthma

2010 ◽  
Vol 3 (12) ◽  
pp. 271-276
Author(s):  
Fabiola Placeres-Uray ◽  
Ramona González de Alfonzo ◽  
Itala Lippo de Becemberg ◽  
Marcelo J. Alfonzo
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Allergic Asthma ◽  
Airway Smooth Muscle ◽  
Guanylyl Cyclase ◽  
Murine Model ◽  
Soluble Guanylyl Cyclase ◽  
Muscle Cells ◽  
Airway Smooth Muscle Cells

The Effect of Bronchoconstriction by Methacholine Inhalation in a Murine Model of Asthma

2020 ◽  
Vol 181 (12) ◽  
pp. 897-907 ◽  
Author(s):  
Yoshito Miyata ◽  
Shin Ohta ◽  
Akihiko Tanaka ◽  
Ayaka Kashima ◽  
Hiromitsu Suganuma ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Airway Inflammation ◽  
Airway Smooth Muscle ◽  
Goblet Cell ◽  
Murine Model ◽  
Transforming Growth Factor ◽  
Airway Remodeling ◽  
Allergic Airway Inflammation ◽  
Cell Counts ◽  
Goblet Cell Metaplasia

<b><i>Introduction:</i></b> Bronchoconstriction was recently shown to cause airway remodeling and induce allergic airway inflammation in asthma. However, the mechanisms how mechanical stress via bronchoconstriction could induce airway inflammation and remodeling remain unclear. <b><i>Objective:</i></b> We investigated the effect of bronchoconstriction induced by methacholine inhalation in a murine model of asthma. <b><i>Methods:</i></b> BALB/c female mice were sensitized and challenged with ovalbumin (OVA), followed by treatment with methacholine by a nebulizer twice a day for 7 days. Twenty-four hours after the last methacholine treatment, the bronchoalveolar lavage fluid (BALF) and lung tissues were collected. The BALF was analyzed for total and differential cell counts and cytokine levels. The lung tissues were analyzed for goblet cell metaplasia, thickness of the smooth muscle, and lung fibrosis. The expression of cytokines in the lung was also examined. <b><i>Results:</i></b> OVA sensitization and challenge induced infiltration of total cells, macrophages, and eosinophils in the BALF along with goblet cell metaplasia and increased airway smooth muscle hypertrophy. Seven days after the last OVA challenge, untreated mice achieved reduction in airway inflammation, while methacholine maintained the number of BALF total cells, macrophages, and eosinophils. The percentage of goblet cells and the thickness of airway smooth muscle were also maintained by methacholine. Moreover, the treatment of methacholine induced the expression of transforming growth factor (TGF)-β in the lung. This result indicates that the production of TGF-β is involved in induction of airway remodeling caused by bronchoconstriction with methacholine. <b><i>Conclusions:</i></b> Repeated bronchoconstriction caused by methacholine inhalation elicited allergic airway inflammation and airway remodeling.

Effect of Imatinib on Airway Smooth Muscle Thickening in a Murine Model of Chronic Asthma

2011 ◽  
Vol 155 (3) ◽  
pp. 243-251 ◽  
Author(s):  
Chin Kook Rhee ◽  
Jin Woo Kim ◽  
Chan Kwon Park ◽  
Joo Sang Kim ◽  
Ji Young Kang ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Airway Smooth Muscle ◽  
Murine Model ◽  
Chronic Asthma
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