Serial Exhaled Nitric Oxide Measurements With a Portable NO Analyzer in Healthy Obstructive Sleep Apnea Patients

CHEST Journal ◽  
2010 ◽  
Vol 138 (4) ◽  
pp. 699A
Author(s):  
Ai-Ping Chua ◽  
Loutfi S. Aboussouan ◽  
Daniel Laskowski ◽  
Omar Minai ◽  
Dweik Raed
Keyword(s):  
Nitric Oxide ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Exhaled Nitric Oxide ◽  
Obstructive Sleep

Exhaled Nitric Oxide as a Potential Biomarker of Continuous Positive Airway Pressure Therapy for Severe Obstructive Sleep Apnea Patients

2021 ◽  
Vol 17 ◽  
Author(s):  
Khue Dang-Thi-Mai ◽  
Nhat-Nam Le-Dong ◽  
Khue Bui-Diem ◽  
Quan Vu-Tran-Thien ◽  
Vinh Nguyen-Nhu ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Continuous Positive Airway Pressure ◽  
Airway Pressure ◽  
Positive Airway Pressure ◽  
Exhaled Nitric Oxide ◽  
Pressure Therapy ◽  
Potential Biomarker ◽  
Obstructive Sleep

Objective: The aim of the present study was to measure the correlation between the level of exhaled Nitric Oxide (NO) and Obstructive Sleep Apnea (OSA) severity and to evaluate its modification after Continuous Positive Airway Pressure (CPAP) treatment in severe OSA patients. Methods: It was a descriptive and cross-sectional study. Subjects were classified by mild-moderate or severe OSA. CPAP was used for severe OSA patients and followed up for 3 months. Exhaled NO was measured in the morning after the previous night of Respiratory Polygraphy (RPG) recording. Results: This study recruited 123 subjects, including 40 mild-moderate and 83 severe OSA patients. The level of maximum bronchial NO production (J’awNO) in patients with severe OSA was significantly higher than mild-moderate OSA [36.2 (6.1–92.2) vs. 19.6 (1.6-73.0) ppb; p=0.001)]. The level of concentration of NO in the gas phase of the alveolar (CANO) in patients with severe OSA was lower than mild-moderate OSA [5.2 (1.2-12.7) vs. 6.9 (0.8-14.0) ppb; p=0.002). The total flux of NO in the conducting airway compartment (J’awNO) and CANO were correlated with an apnea-hypopnea index (AHI) (rho=0.25 and p=0.02; rho= 0.18 and p=0.04, respectively). There was a weak significant correlation between J’awNO and nadir SpO2 in patients with OSA (rho = -0.22 and p= 0.023). After 3-month treatment with CPAP, the level of J’awNO was significantly reduced in patients with severe OSA [23.4 (12.9-44.5) vs. 33.1 (21.2-55.0); p<0.001. Conclusion: J'awNO is proportionally increased in patients with severe OSA and reduced after treatment with CPAP. Thus, J’awNO may be used as a relevant and surrogate biomarker of severe OSA.

Alveolar-Derived Exhaled Nitric Oxide Is Reduced in Obstructive Sleep Apnea Syndrome

CHEST Journal ◽  
2007 ◽  
Vol 132 (3) ◽  
pp. 860-867 ◽  
Author(s):  
Antonio Foresi ◽  
Clementina Leone ◽  
Dario Olivieri ◽  
George Cremona
Keyword(s):  
Nitric Oxide ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Exhaled Nitric Oxide ◽  
Obstructive Sleep ◽  
Apnea Syndrome

Exhaled pH, exhaled nitric oxide, and induced sputum cellularity in obese patients with obstructive sleep apnea syndrome

2008 ◽  
Vol 151 (1) ◽  
pp. 45-50 ◽  
Author(s):  
Giovanna E. Carpagnano ◽  
Antonio Spanevello ◽  
Roberto Sabato ◽  
Annarita Depalo ◽  
Viviana Turchiarelli ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Exhaled Nitric Oxide ◽  
Induced Sputum ◽  
Obese Patients ◽  
Obstructive Sleep ◽  
Apnea Syndrome

scholarly journals Measurement of exhaled nitric oxide concentration in patients with obstructive sleep apnea

Medicine ◽  
2017 ◽  
Vol 96 (12) ◽  
pp. e6429 ◽  
Author(s):  
Dongmei Zhang ◽  
Jinmei Luo ◽  
Yixian Qiao ◽  
Yi Xiao ◽  
Rong Huang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Exhaled Nitric Oxide ◽  
Obstructive Sleep ◽  
Oxide Concentration ◽  
Nitric Oxide Concentration

scholarly journals Study of Exhaled Nitric Oxide in Subjects with Suspected Obstructive Sleep Apnea: A Pilot Study in Vietnam

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Sy Duong-Quy ◽  
Thong Hua-Huy ◽  
Huyen-Tran Tran-Mai-Thi ◽  
Nhat-Nam Le-Dong ◽  
Timothy J. Craig ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Surrogate Marker ◽  
High Specificity ◽  
Exhaled Nitric Oxide ◽  
Apnea Hypopnea Index ◽  
Cross Sectional ◽  
Control Subjects ◽  
Obstructive Sleep

Background and Objective. The concentration of exhaled nitric oxide (eNO), reflecting the activity of inducible NO synthase in airway epithelium, has been found to increase in patients with obstructive sleep apnea (OSA). This study aimed to measure eNO concentration in patients with suspected OSA and to correlate different eNO parameters with clinical and sleep apnea characteristics.Methods. In this cross-sectional study, all patients underwent in-lab overnight polysomnography (PSG) and eNO measurement using a method of multiple flow rates before and after PSG (pre- and post-PSG).Results. According to the result of PSG, 82 persons were divided into two groups: control subjects (n=30;54±14years) and patients with OSA defined as apnea-hypopnea index (AHI) ≥ 5/hour (n=52;53±12years). Body mass index (BMI) and neck and abdomen circumferences of OSA patients were significantly higher than those from control subjects. In OSA group, post-PSG alveolar NO concentration (CANO) (5.3±1.9 ppb) was significantly higher than pre-PSG CANO (4.0±1.7 ppb;P<0.001). Significant correlations have been found between CANO and AHI (P<0.001) and between CANO and nadir SpO2(P<0.05). The daytime CANO value of more than 4.1 ppb can be used to screen symptomatic subjects for the presence of OSA with a high specificity of 93.3%.Conclusion. Our findings indicate CANO as a surrogate marker for OSA in persons with suggestive symptoms.

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