Physical Functioning, Six-Minute Walk Distance, and Pulmonary Vascular Resistance in Adult Patients With Pulmonary Arterial Hypertension Treated With Sildenafil: Examining the Distributions of Outcomes

CHEST Journal ◽  
2010 ◽  
Vol 138 (4) ◽  
pp. 362A ◽  
Author(s):  
Joseph C. Cappelleri ◽  
Marko A. Mychaskiw ◽  
Lie-Ju Hwang ◽  
Jack Mardekian ◽  
Kabir Quazi
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Pulmonary Vascular Resistance ◽  
Vascular Resistance ◽  
Physical Functioning ◽  
Adult Patients ◽  
Walk Distance ◽  
Pulmonary Arterial ◽  
Minute Walk Distance ◽  
Minute Walk

scholarly journals Novel dose–response analyses of treprostinil in pulmonary arterial hypertension and its effects on six-minute walk distance and hospitalizations

2020 ◽  
Vol 10 (3) ◽  
pp. 204589402092395
Author(s):  
Gautam Ramani ◽  
Steven Cassady ◽  
Eric Shen ◽  
Meredith Broderick ◽  
Allie Wasik ◽  
...  
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Dose Response ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Walk Distance ◽  
Pulmonary Arterial ◽  
Higher Doses ◽  
Minute Walk Distance ◽  
Minute Walk

Treprostinil is a prostacyclin analogue approved for the treatment of pulmonary arterial hypertension. Apart from the inhaled formulation, there is neither a target dose nor a ceiling dose to guide clinicians using treprostinil; doses are individualized for each patient based upon tolerability and clinical improvement. Using combined data from the pivotal subcutaneous and oral treprostinil studies, we evaluated the effect of treprostinil dose on hospitalization and exercise capacity to better define the treprostinil dose–response relationship. Data from the pivotal subcutaneous and oral treprostinil studies were combined by converting oral doses to weight-based continuous doses (ng/kg/min) accounting for patient weight and bioavailability. Patients were divided into dose tertiles (lowest, middle, highest 33%) and retrospectively analyzed. Analysis 1 assessed the effect of dose on pulmonary arterial hypertension-related and all-cause hospitalizations. Analysis 2 evaluated the effects of dose on six-minute walk distance, Borg dyspnea score, and World Health Organization functional class. Results showed that, in Analysis 1, higher doses of treprostinil were associated with significantly longer times to first pulmonary arterial hypertension-related and all-cause hospitalization. In Analysis 2, there was a trend toward improvements in six-minute walk distance with higher doses. In patients with pulmonary arterial hypertension on systemic treprostinil therapy, higher doses were associated with significantly longer time to first pulmonary arterial hypertension-related and all-cause hospitalization. There was a trend toward improvements in six-minute walk distance. Collectively, these results underscore the importance of managing prostacyclin adverse events in order to achieve appropriate dose titration. Further studies are required to confirm these findings and to better characterize the dose–response relationship of treprostinil.

scholarly journals Do Changes of 6-Minute Walk Distance Predict Clinical Events in Patients With Pulmonary Arterial Hypertension?

2012 ◽  
Vol 60 (13) ◽  
pp. 1192-1201 ◽  
Author(s):  
Gianluigi Savarese ◽  
Stefania Paolillo ◽  
Pierluigi Costanzo ◽  
Carmen D'Amore ◽  
Milena Cecere ◽  
...  
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Walk Distance ◽  
Clinical Events ◽  
Pulmonary Arterial ◽  
Minute Walk Distance ◽  
Minute Walk

scholarly journals Long-term study of oral treprostinil to treat pulmonary arterial hypertension: dosing, tolerability, and pharmacokinetics

2020 ◽  
Vol 10 (4) ◽  
pp. 204589401986633 ◽  
Author(s):  
R. James White ◽  
Keyur Parikh ◽  
Roblee Allen ◽  
Jeremy Feldman ◽  
Carlos Jerjez-Sanchez ◽  
...  
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Adverse Events ◽  
Arterial Hypertension ◽  
Total Daily Dose ◽  
Walk Distance ◽  
Long Term Study ◽  
Pulmonary Arterial ◽  
One Year ◽  
Minute Walk Distance ◽  
Minute Walk

Oral treprostinil may be an option for low- and intermediate-risk patients with pulmonary arterial hypertension, a rare lung vascular disease. This open-label extension study collected data on participants who completed previously reported, placebo-controlled oral treprostinil studies. Eligible participants had completed the prospective parent studies and took increasing doses of oral treprostinil twice daily; some later transitioned to three times daily dosing. Investigators measured 6-minute walk distance at Month 12 as the sole efficacy measure but collected adverse events throughout the study. A single center measured pharmacokinetics in 13 subjects who changed dosing from twice daily to three times daily. Eight hundred and ninety-four participants enrolled and 71% completed one year of therapy, with a median total daily dose of 7 mg and a median 6-minute walk distance increase of 22 m (interquartile range, −14 to 67 m). Subjects achieving higher doses had larger increases in 6-minute walk distance; 42% of participants completed three years of therapy. Adverse events were typical for prostacyclin class therapy, but prostacyclin-type adverse events may have been better tolerated with three times daily dosing in 105 participants. In 13 participants transitioned to three times daily dosing with pharmacokinetic measurements before and after, trough drug levels were higher with three times daily dosing. Oral treprostinil is associated with modest but durable, dose-responsive effects on exercise tolerance for those who remained on therapy at one year in this prospective, uncontrolled study. Three times daily dosing was associated with higher trough levels and better tolerability. The recently completed Freedom-EV study will provide further insights into the utility of oral treprostinil ( https://clinicaltrials.gov/show/NCT01560624 ).

scholarly journals Association between six-minute walk distance and long-term outcomes in patients with pulmonary arterial hypertension: Data from the randomized SERAPHIN trial

PLoS ONE ◽  
2018 ◽  
Vol 13 (3) ◽  
pp. e0193226 ◽  
Author(s):  
Rogério Souza ◽  
Richard N. Channick ◽  
Marion Delcroix ◽  
Nazzareno Galiè ◽  
Hossein-Ardeschir Ghofrani ◽  
...  
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Long Term Outcomes ◽  
Walk Distance ◽  
Pulmonary Arterial ◽  
Minute Walk Distance ◽  
Minute Walk
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