Predisposition to and Late Onset of Upper Airway Obstruction following Angiotensin-Converting Enzyme Inhibitor Therapy

CHEST Journal ◽  
1992 ◽  
Vol 102 (3) ◽  
pp. 871-874 ◽  
Author(s):  
Manu Jain ◽  
Lora Armstrong ◽  
Jesse Hall
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Airway Obstruction ◽  
Angiotensin Converting Enzyme Inhibitor ◽  
Enzyme Inhibitor ◽  
Late Onset ◽  
Upper Airway ◽  
Inhibitor Therapy ◽  
Upper Airway Obstruction ◽  
Converting Enzyme ◽  
Converting Enzyme Inhibitor

Late-Onset Life-Threatening Angioedema and Upper Airway Obstruction Caused by Angiotensin-Converting Enzyme Inhibitor: Report of a Case

1997 ◽  
Vol 76 (6) ◽  
pp. 404-407 ◽  
Author(s):  
Ping-Kun Weng ◽  
Hsing-Won Wang ◽  
John K. Lin ◽  
Wen-Yang Su
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Airway Obstruction ◽  
Enzyme Inhibitor ◽  
Late Onset ◽  
Upper Airway ◽  
Temporal Correlation ◽  
Angiotensin Converting Enzyme Inhibitors ◽  
Upper Airway Obstruction ◽  
Converting Enzyme ◽  
Converting Enzyme Inhibitors

Angioedema is a rare but potentially lethal adverse effect when associated with upper airway obstruction. Sporadic cases of angioedema secondary to angiotensin converting enzyme inhibitors (ACEI) have been reported in the literature. The overall incidence is around 0.1% to 0.2%, and the time of onset is usually during the first week of ACEI therapy. Late-onset angioedema secondary to treatment with ACEIs is much more frequent than appreciated, and is largely unrecognized because of the absence of temporal correlation between ACEI therapy and the development of angioedema. Since angioedema may progress to upper airway obstruction, otolaryngologists must be aware of this association. Most importantly, late-onset angioedema should alert the clinician to discontinue the A CEI immediately to prevent further morbidity. This report presents an example of late-onset angioedema which was precipitated by taking a double dose of Captopril incidentally. The case is discussed, and the literature, pathophysiology and treatment of angioedema are reviewed.

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