Central and Peripheral Airway Sites of Nitric Oxide Gas Exchange in COPD

CHEST Journal ◽  
2010 ◽  
Vol 137 (3) ◽  
pp. 575-584 ◽  
Author(s):  
Arthur F. Gelb ◽  
Colleen Flynn Taylor ◽  
Anita Krishnan ◽  
Christine Fraser ◽  
Chris M. Shinar ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Gas Exchange ◽  
Peripheral Airway

Effect of inhaled nitric oxide on pulmonary hemodynamics after acute lung injury in dogs

1994 ◽  
Vol 76 (3) ◽  
pp. 1356-1362 ◽  
Author(s):  
J. A. Romand ◽  
M. R. Pinsky ◽  
L. Firestone ◽  
H. A. Zar ◽  
J. R. Lancaster
Keyword(s):  
Nitric Oxide ◽  
Acute Lung Injury ◽  
Gas Exchange ◽  
Lung Injury ◽  
Dead Space ◽  
Left Ventricular ◽  
Right Atrial ◽  
Adrenergic Blockade ◽  
Pulmonary Hemodynamics ◽  
Beta Adrenergic

Increased pulmonary vascular resistance (PVR) and mismatch in ventilation-to-perfusion ratio characterize acute lung injury (ALI). Pulmonary arterial pressure (Ppa) decreases when nitric oxide (NO) is inhaled during hypoxic pulmonary vasoconstriction (HPV); thus NO inhalation may reduce PVR and improve gas exchange in ALI. We studied the hemodynamic and gas exchange effects of NO inhalation during HPV and then ALI in eight anesthetized open-chest mechanically ventilated dogs. Right atrial pressure, Ppa, and left ventricular and arterial pressures were measured, and cardiac output was estimated by an aortic flow probe. Shunt and dead space were also estimated. The effect of 5-min exposures to 0, 17, 28, 47, and 0 ppm inhaled NO was recorded during hyperoxia, hypoxia, and oleic acid-induced ALI. During ALI, partial beta-adrenergic blockade (propranolol, 0.15 mg/kg i.v.) was induced and 74 ppm NO was inhaled. Nitrosylhemoglobin (NO-Hb) and methemoglobin (MetHb) levels were measured. During hyperoxia, NO inhalation had no measurable effects. Hypoxia increased Ppa (from 19.8 +/- 6.1 to 28.3 +/- 8.7 mmHg, P < 0.01) and calculated PVR (from 437 +/- 139 to 720 +/- 264 dyn.s.cm-5, P < 0.01), both of which decreased with 17 ppm NO. ALI decreased arterial PO2 and increased airway pressure, shunt, and dead space ventilation. Ppa (19.8 +/- 6.1 vs. 23.4 +/- 7.7 mmHg) and PVR (437 +/- 139 vs. 695 +/- 359 dyn.s.cm-5, P < 0.05) were greater during ALI than during hyperoxia. No inhalation had no measureable effect during ALI before or after beta-adrenergic blockade. MetHb remained low, and NO-Hb was unmeasurable. Bolus infusion of nitroglycerin (15 micrograms) induced an immediate decrease in Ppa and PVR during ALI.(ABSTRACT TRUNCATED AT 250 WORDS)

scholarly journals Inhibitor of neuronal nitric oxide synthase improves gas exchange in ventilator-induced lung injury after pneumonectomy

2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Evgeny V Suborov ◽  
Alexey A Smetkin ◽  
Timofey V Kondratiev ◽  
Andrey Y Valkov ◽  
Vsevolod V Kuzkov ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Gas Exchange ◽  
Lung Injury ◽  
Neuronal Nitric Oxide Synthase ◽  
Ventilator Induced Lung Injury ◽  
Oxide Synthase

Combining partial liquid ventilation with nitric oxide to improve gas exchange in acute lung injury

1997 ◽  
Vol 23 (2) ◽  
pp. 163-169 ◽  
Author(s):  
R.-J. M. Houmes ◽  
A. Hartog ◽  
S. J. C. Verbrugge ◽  
S. Böhm ◽  
B. Lachmann
Keyword(s):  
Nitric Oxide ◽  
Acute Lung Injury ◽  
Gas Exchange ◽  
Lung Injury ◽  
Partial Liquid Ventilation ◽  
Liquid Ventilation

Nitric oxide contamination of hospital compressed air improves gas exchange in patients with acute lung injury

2002 ◽  
Vol 28 (8) ◽  
pp. 1064-1072 ◽  
Author(s):  
Seow P. Tan ◽  
F. Genc ◽  
E. Delgado ◽  
J. Kellum ◽  
M. Pinsky
Keyword(s):  
Nitric Oxide ◽  
Acute Lung Injury ◽  
Gas Exchange ◽  
Lung Injury ◽  
Compressed Air ◽  
Oxide Contamination
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