Pathologic and Radiologic Differences Between Idiopathic and Collagen Vascular Disease-Related Usual Interstitial Pneumonia

CHEST Journal ◽  
2009 ◽  
Vol 136 (1) ◽  
pp. 23-30 ◽  
Author(s):  
Jin Woo Song ◽  
Kyung-Hyun Do ◽  
Mi-Young Kim ◽  
Se Jin Jang ◽  
Thomas V. Colby ◽  
...  
Keyword(s):  
Vascular Disease ◽  
Interstitial Pneumonia ◽  
Usual Interstitial Pneumonia ◽  
Collagen Vascular Disease

Nonspecific Interstitial Pneumonia

Chest Imaging ◽  
2019 ◽  
pp. 459-462
Author(s):  
Cylen Javidan-Nejad
Keyword(s):  
Vascular Disease ◽  
Interstitial Pneumonia ◽  
Drug Toxicity ◽  
Hypersensitivity Pneumonitis ◽  
Usual Interstitial Pneumonia ◽  
Ground Glass Opacity ◽  
Collagen Vascular Disease ◽  
Air Trapping ◽  
Underlying Condition ◽  
Nonspecific Interstitial Pneumonia

Nonspecific interstitial pneumonia (NSIP) represents a less common idiopathic interstitial pneumonia than usual interstitial pneumonia (UIP) with a much better prognosis. Most cases of NSIP are secondary to collagen vascular disease, hypersensitivity or drug toxicity. These secondary forms of NSIP help to explain why it is more often seen on CT than UIP. Unlike UIP, NSIP is characterized by a paucity of honeycombing on CT and greater ground-glass opacity and reticulation. Subpleural sparing when present may suggest the diagnosis. Unlike UIP, NSIP tends to exhibit histologic spatial and temporal homogeneity. When extensive bronchiectasis is seen in association with an NSIP pattern, collagen vascular disease must be considered. When air trapping is encountered, hypersensitivity pneumonitis must be excluded. Biopsy is usually reserved for those patients with an NSIP pattern who do not have a known underlying condition. If the diagnosis of NSIP can be made, immunotherapy may prevent progression and may even reverse some CT findings.

Organizing Pneumonia

Chest Imaging ◽  
2019 ◽  
pp. 463-468
Author(s):  
Cylen Javidan-Nejad
Keyword(s):  
Drug Therapy ◽  
Lung Injury ◽  
Vascular Disease ◽  
Interstitial Pneumonia ◽  
Organizing Pneumonia ◽  
Collagen Vascular Disease ◽  
Cryptogenic Organizing Pneumonia ◽  
Halo Sign ◽  
Classic Pattern

Organizing pneumonia (OP) is a nonfibrotic form of interstitial pneumonia that represents a manifestation of lung injury. It may be secondary to another process (such as vasculitis, collagen vascular disease, or drug therapy). When no inciting cause is found, the OP is believed to cryptogenic and the term Cryptogenic Organizing Pneumonia (COP) may be used clinically. Various patterns of OP may be encountered on imaging including classic (peripheral or bronchiolocentric consolidation), focal, crescentic, multinodular and fibrotic. The classic pattern is the most common, but the crescentic form (often known as the atoll or reverse halo sign) can be the most striking. The latter two patterns are more typical of OP associated with collagen vascular disease, most notably dermatomyositis and polymyositis.

scholarly journals Nonspecific Interstitial Pneumonia Associated with Collagen Vascular Disease: Analysis of CT Features to Distinguish the Various Types

2009 ◽  
Vol 48 (10) ◽  
pp. 753-761 ◽  
Author(s):  
Tadahisa Daimon ◽  
Takeshi Johkoh ◽  
Osamu Honda ◽  
Hiromitsu Sumikawa ◽  
Kazuya Ichikado ◽  
...  
Keyword(s):  
Vascular Disease ◽  
Interstitial Pneumonia ◽  
Collagen Vascular Disease ◽  
Nonspecific Interstitial Pneumonia ◽  
Disease Analysis ◽  
Ct Features
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