8-Isoprostane in Exhaled Breath Condensate and Exercise-Induced Bronchoconstriction in Asthmatic Children and Adolescents

CHEST Journal ◽  
2009 ◽  
Vol 135 (1) ◽  
pp. 66-73 ◽  
Author(s):  
Mario Barreto ◽  
Maria Pia Villa ◽  
Carla Olita ◽  
Susy Martella ◽  
Giovanni Ciabattoni ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Exhaled Breath Condensate ◽  
Exhaled Breath ◽  
Asthmatic Children ◽  
Exercise Induced ◽  
Breath Condensate

Exhaled breath condensate cysteinyl leukotrienes are increased in children with exercise-induced bronchoconstriction

2005 ◽  
Vol 115 (4) ◽  
pp. 764-770 ◽  
Author(s):  
Silvia Carraro ◽  
Massimo Corradi ◽  
Stefania Zanconato ◽  
Rossella Alinovi ◽  
Maria Francesca Pasquale ◽  
...  
Keyword(s):  
Exhaled Breath Condensate ◽  
Exhaled Breath ◽  
Cysteinyl Leukotrienes ◽  
Exercise Induced ◽  
Breath Condensate

scholarly journals Metabolites of L-ARG in Exhaled Breath Condensate and Serum Are Not Biomarkers of Bronchial Asthma in Children

2022 ◽  
Vol 11 (1) ◽  
pp. 252
Author(s):  
Joanna Połomska ◽  
Barbara Sozańska
Keyword(s):  
Bronchial Asthma ◽  
Pediatric Patients ◽  
Exhaled Breath Condensate ◽  
Mass Spectrometric ◽  
Mass Spectrometric Analysis ◽  
Spectrometric Analysis ◽  
Exhaled Breath ◽  
Asthmatic Children ◽  
Healthy Control ◽  
Breath Condensate

(1) Background: L-arginine (L-ARG) and its metabolites are involved in some aspects of asthma pathogenesis (airway inflammation, oxidative stress, bronchial responsiveness, collagen deposition). Published data indicate that lungs are a critical organ for the regulation of L-ARG metabolism and that alterations in L-ARG metabolism may be significant for asthma. The aim of this study was to assess the levels of L-ARG and its metabolites in pediatric patients with asthma in serum and exhaled breath condensate (EBC) by mass spectrometric analysis and compare them with non-asthmatic children. (2) Methods: Sixty-five children (37 pediatric patients with bronchial asthma and 28 healthy control subjects) aged 6–17 participated in the study. All participants underwent a clinical visit, lung tests, allergy tests with common aeroallergens, and serum and EBC collection. The levels of biomarkers were determined in both serum and EBC. Analytical chromatography was conducted using an Acquity UPLC system equipped with a cooled autosampler and an Acquity HSS T3 column. Mass spectrometric analysis was conducted using the Xevo G2 QTOF MS with electrospray ionization (ESI) in positive ion mode. (3) Results: Asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) levels in serum and EBC did not differ significantly in asthmatic children and healthy control subjects. We found no correlation between forced expiratory volume in one second (FEV1) and L-ARG and its metabolites, as well as between interleukin-4 (IL-4) serum level and L-ARG and its metabolites. Concentrations of ADMA, SDMA, citrulline (CIT), and ornithine (ORN) were higher in serum than EBC in asthmatics and non-asthmatics. By contrast, concentrations of dimethylarginine (DMA) were higher in EBC than serum. ADMA/L-ARG, SDMA/L-ARG, and DMA/L-ARG ratios were significantly higher in EBC than in serum in asthmatics and in non-asthmatics. (4) Conclusions: Serum and EBC concentrations of L-ARG and its metabolites were not an indicator of pediatric bronchial asthma in our study.

Increased inflammatory mediator in exhaled breath condensate from asthmatic children

2014 ◽  
Vol 2 (5) ◽  
pp. 332
Author(s):  
Yoon Ki Han ◽  
Jun Young Park ◽  
Mi Na Kim ◽  
Yoon Hee Kim ◽  
Hyun Bin Park ◽  
...  
Keyword(s):  
Inflammatory Mediator ◽  
Exhaled Breath Condensate ◽  
Exhaled Breath ◽  
Asthmatic Children ◽  
Breath Condensate

scholarly journals IL-5, IL-8 and MMP -9 levels in exhaled breath condensate of atopic and nonatopic asthmatic children

2015 ◽  
Vol 109 (6) ◽  
pp. 680-688 ◽  
Author(s):  
Ahmet Turkeli ◽  
Ozge Yilmaz ◽  
Fatma Taneli ◽  
Gonul Dinc Horasan ◽  
Esra Toprak Kanik ◽  
...  
Keyword(s):  
Exhaled Breath Condensate ◽  
Exhaled Breath ◽  
Asthmatic Children ◽  
Breath Condensate

Increased Leukotriene B4 In Exhaled Breath Condensate From Asthmatic Children

2007 ◽  
Vol 119 (1) ◽  
pp. S291
Author(s):  
J.Y. Park ◽  
K.W. Kim ◽  
E.S. Kim ◽  
J.Y. Hong ◽  
C.H. Kim ◽  
...  
Keyword(s):  
Exhaled Breath Condensate ◽  
Leukotriene B4 ◽  
Exhaled Breath ◽  
Asthmatic Children ◽  
Breath Condensate

Metabolomics applied to exhaled breath condensate in asthmatic children treated with inhaled steroids

2020 ◽  
Author(s):  
Valentina Agnese Ferraro ◽  
Silvia Carraro ◽  
Paola Pirillo ◽  
Gabriele Poloniato ◽  
Matteo Stocchero ◽  
...  
Keyword(s):  
Exhaled Breath Condensate ◽  
Exhaled Breath ◽  
Asthmatic Children ◽  
Inhaled Steroids ◽  
Breath Condensate
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