scholarly journals Lipoprotein Candidate Genes for Multivariate Factors of the Insulin Resistance Syndrome: A Sib-pair Linkage Analysis in Women Twins

Twin Research ◽  
2001 ◽  
Vol 4 (1) ◽  
pp. 41-47 ◽  
Author(s):  
K.L. Edwards ◽  
P.J. Talmud ◽  
B. Newman ◽  
R. M. Krauss ◽  
M.A. Austin
Keyword(s):  
Insulin Resistance ◽  
Linkage Analysis ◽  
Candidate Genes ◽  
Insulin Resistance Syndrome

Bivariate Linkage Analysis of the Insulin Resistance Syndrome Phenotypes on Chromosome 7q

Human Biology ◽  
2005 ◽  
Vol 77 (2) ◽  
pp. 231-246 ◽  
Author(s):  
Donna M. Lehman ◽  
Rector Arya ◽  
John Blangero ◽  
Laura Almasy ◽  
Sobha Puppala ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Linkage Analysis ◽  
Insulin Resistance Syndrome ◽  
Bivariate Linkage Analysis ◽  
Chromosome 7Q

Lipoprotein Candidate Genes for Multivariate Factors of the Insulin Resistance Syndrome: A Sib-pair Linkage Analysis in Women Twins

Twin Research ◽  
2001 ◽  
Vol 4 (1) ◽  
pp. 41-47 ◽  
Author(s):  
K.L. Edwards ◽  
P.J. Talmud ◽  
B. Newman ◽  
R.M. Krauss ◽  
M.A. Austin
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Candidate Genes ◽  
Disease Risk ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Insulin Resistance Syndrome ◽  
Kaiser Permanente ◽  
Ldl Size ◽  
Apo E

AbstractThe insulin resistance syndrome (IRS) is characterized by a combination of interrelated coronary heart disease risk factors, including low high-density lipoprotein cholesterol (HDLC) levels, obesity and increases in triglyceride (TG), systolic and diastolic blood pressure (BP), small low-density lipoprotein particles (LDL-size), and fasting and postload plasma insulin and glucose. Using factor analysis, we previously identified multivariate factors based on data from women participating in the Kaiser Permanente Women Twins Study: 1) Weight/Fat, 2) Insulin/Glucose, 3) Lipids, and 4) BP. The purpose of this study is to evaluate evidence for genetic linkage between the multivariate factors and candidate genes. Quantitative sib-pair analysis based on the factor scores with markers for 9 candidate genes was carried out based on data from 126 pairs of dizygotic (DZ) women twins from the second exam of the Kaiser Permanente Women Twins study. Suggestive evidence for linkage was found for the Weight/fat factor and the Apo E gene (p= 0.01), and stronger evidence for linkage with the Lipid factor and the cholesterol ester transfer protein (p= 0.002) gene. Therefore, the CETP gene appears to influence covariation in LDL size, TG, and HDL, and may account for a portion of the well-established statistical and metabolic associations observed between these risk factors.

HFE genotype and the insulin resistance syndrome among subjects with iron overload

2001 ◽  
Vol 120 (5) ◽  
pp. A565-A565
Author(s):  
J TALWALKAR ◽  
H TORGERSON ◽  
D BRANDHAGEN
Keyword(s):  
Insulin Resistance ◽  
Iron Overload ◽  
Insulin Resistance Syndrome

Features of insulin-resistance syndrome in men from French Caribbean Islands. The Telecom Study

Diabetes ◽  
1992 ◽  
Vol 41 (11) ◽  
pp. 1385-1389 ◽  
Author(s):  
A. Fontbonne ◽  
L. Papoz ◽  
E. Eschwege ◽  
M. Roger ◽  
M. Saint-Paul ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Insulin Resistance Syndrome ◽  
French Caribbean ◽  
Caribbean Islands

scholarly journals Interaction of physical activity and diet: implications for insulin-glucose dynamics

1999 ◽  
Vol 2 (3a) ◽  
pp. 363-368 ◽  
Author(s):  
Jean-Jacques Grimm
Keyword(s):  
Insulin Resistance ◽  
Cardiovascular Risk ◽  
Fatty Acid ◽  
Glycogen Synthase ◽  
Insulin Resistance Syndrome ◽  
Low Fat ◽  
Exercise Interventions ◽  
High Carbohydrate ◽  
Fat Diets

AbstractIn Western countries 25–35% of the population have insulin resistance syndrome characteristics.The defects most likely to explain the insulin resistance of the insulin resistance syndrome include: 1) the glucose transport system of skeletal muscle (GLUT-4) and its different signalling proteins and enzymes; 2) glucose phosphorylation by hexokinase; 3) glycogen synthase activity and 4) competition between glucose and fatty acid oxidation (glucose-fatty acid cycle).High carbohydrate/low fat diets deteriorate insulin sensitivity on the short term. Howewer, on the long term, high fat/low carbohydrate diets have a lower satiating power, induce low leptin levels and eventually lead to higher energy consumption, obesity and more insulin resistance. Moderately high-carbohydrate (45–55% of the daily calories)/low-fat diets seem to be a good choice with regard to the prevention of diabetes and cardiovascular risk factors as far as the carbohydrates are rich in fibers.Long-term interventions with regular exercise programs show a 1/3 decrease in the appearance of overt diabetes in glucose intolerant subjects. Furthermore, diet and exercise interventions "normalise" the mortality rate of patients with impared glucose tolerance.Therefore, moderately high carbohydrate/low fat diets are most likely to prevent obesity and type 2 diabetes. Triglycerides should be monitored and, in some cases, a part of the carbohydrates could be replaced by fat rich in monounsaturated fatty acids. However, total caloric intake is of utmost importance, as weight gain is the major determinant for the onset of insulin resistance and glucose intolerance.Regular (when possible daily) exercise, decreases cardiovascular risk. With regard to insulin resistance, resistance training seems to offer some advantages over aerobic endurance activities.

Sign in / Sign up

Export Citation Format

Share Document