scholarly journals Population Distribution of High-Sensitivity C-reactive Protein among US Men: Findings from National Health and Nutrition Examination Survey 1999–2000

2003 ◽  
Vol 49 (4) ◽  
pp. 686-690 ◽  
Author(s):  
Earl S Ford ◽  
Wayne H Giles ◽  
Gary L Myers ◽  
David M Mannino
Keyword(s):  
National Health ◽  
Population Distribution ◽  
High Sensitivity ◽  
Nutrition Examination Survey ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Health And Nutrition

scholarly journals C-reactive Protein Concentration Distribution among US Children and Young Adults: Findings from the National Health and Nutrition Examination Survey, 1999–2000

2003 ◽  
Vol 49 (8) ◽  
pp. 1353-1357 ◽  
Author(s):  
Earl S Ford ◽  
Wayne H Giles ◽  
Gary L Myers ◽  
Nader Rifai ◽  
Paul M Ridker ◽  
...  
Keyword(s):  
Young Adults ◽  
National Health ◽  
Concentration Distribution ◽  
High Sensitivity ◽  
Nutrition Examination Survey ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Health And Nutrition ◽  
Children And Young Adults ◽  
Us Children

Abstract Background: The distribution of C-reactive protein (CRP) concentrations among children and young adults in the US is not known at present. Methods: We used data from 3348 US children and young adults 3–19 years of age who participated in the National Health and Nutrition Examination Survey, 1999–2000, to describe the distribution of CRP concentrations, based on results obtained with a high-sensitivity latex-enhanced turbidimetric assay. Results: The range of CRP concentrations was 0.1–90.8 mg/L (mean, 1.6 mg/L; geometric mean, 0.5 mg/L; median, 0.4 mg/L). CRP concentrations increased with age. Females 16–19 years of age had higher concentrations than males in this age range (P = 0.003). Mexican Americans had the highest CRP concentrations among the three major race or ethnic groups (P <0.001). Conclusions: For the first time, these data describe the CRP concentration distribution among US children and young adults, based on results obtained with a high-sensitivity assay.

scholarly journals Sex differences in the association between self-rated health and high-sensitivity C-reactive protein levels in Koreans: A cross-sectional study using Korea National Health and Nutrition Examination Survey (KNHANES)

2020 ◽  
Author(s):  
Se-Won Park ◽  
Seong-Sik Park ◽  
Eun-Jung Kim ◽  
Won-Suk Sung ◽  
In-Hyuk Ha ◽  
...  
Keyword(s):  
National Health ◽  
High Sensitivity ◽  
Nutrition Examination Survey ◽  
C Reactive Protein ◽  
High Group ◽  
Reactive Protein ◽  
Self Rated Health ◽  
Health And Nutrition ◽  
Hs Crp ◽  
Level Group

Abstract Background No studies have investigated the association between self-rated health (SRH) and high-sensitivity C-reactive protein (hs-CRP) in South Koreans. This study explored the association and analyzed any sex differences.Method Using data from the 2015-2017 Korea National Health and Nutrition Examination Survey, we analyzed the association between SRH and high group (>1.0 mg/L) in 14,544 Koreans aged ≥19 years who responded to the SRH survey and who had hs-CRP test results. Results The percentage of having a very poor to poor SRH was higher in the high hs-CRP level group (22.4%) than in the low level group (17.66%). Among males, the risk of a high hs-CRP level increased with worse SRH (adjusted for confounders; P for trend <0.001). After adjusting for all confounders, including chronic diseases, males with a very poor SRH showed higher odds ratio (OR) for high group than those with a very good SRH (fully adjusted OR, 1.74; 95% confidence interval, 1.04-2.90). Significant correlations were absent among females. Conclusions A poor SRH was correlated with low-grade inflammation (high hs-CRP level) among male Korean adults. The findings could be useful for developing health improvement programs and in goal setting at a national scale.

scholarly journals Hyperuricemia, Elevated Body Mass Index, Female Sex, and Albuminuria Increase the Probability of Elevated High-Sensitivity C-Reactive Protein: Results From the National Health and Nutrition Examination Survey 2015–2018

2021 ◽  
Vol 9 ◽  
Author(s):  
Cristin D. W. Kaspar ◽  
Juan Lu
Keyword(s):  
Body Mass Index ◽  
Systemic Inflammation ◽  
National Health ◽  
High Sensitivity ◽  
Nutrition Examination Survey ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Female Sex ◽  
Health And Nutrition ◽  
Hs Crp

Importance: High uric acid (UA) is hypothesized to worsen kidney and cardiovascular disease morbidity via activation of systemic inflammation. Clinical trials of UA modification report reduction of the inflammatory marker high sensitivity C-reactive protein (hs-CRP) as an outcome measure, but studies have not demonstrated that hyperuricemia independently increases hs-CRP when adjusted for important confounders such as body mass index (BMI), sex, and age.Objective: To identify clinical risk factors for elevated hs-CRP, including but not limited to hyperuricemia, through a cross-sectional analysis of the National Health and Nutrition Examination Survey (NHANES) 2015–2018.Results: In the final multivariate logistic regression model, the exposure with the strongest effect on the odds of elevated hs-CRP was BMI in the fourth quartile, OR = 13.1 (95% CI 6.25–27.42), followed by female sex (OR = 4.9, 95% CI 2.92–8.34), hyperuricemia (OR = 2.2, 95% CI 1.36–3.45), urine albumin creatinine ratio (ACR; OR = 1.5, 95% CI 1.09–2.18), poor overall health (OR = 1.4, 95% CI 1.18–1.58), and interactions between hyperuricemia and sex (OR = 1.4, 95% CI 1.05–1.83), and between BMI and sex (OR = 1.2, 95% CI 1.03–1.47). Notably, chronic kidney disease (CKD) and CKD surrogates were not associated with hs-CRP despite urine ACR maintaining a significant independent effect.Conclusions: In this national population-based study, we demonstrated that hyperuricemia significantly increases the odds of elevated hs-CRP, independent from BMI, female sex, urine ACR, and overall health status. Further study is recommended to better understand the sex difference in this association and the role of albuminuria, but not CKD, in systemic inflammation.

scholarly journals Sex differences in the association between self-rated health and high-sensitivity C-reactive protein levels in Koreans: a cross-sectional study using data from the Korea National Health and Nutrition Examination Survey

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Se-Won Park ◽  
Seong-Sik Park ◽  
Eun-Jung Kim ◽  
Won-Suk Sung ◽  
In-Hyuk Ha ◽  
...  
Keyword(s):  
National Health ◽  
High Sensitivity ◽  
Categorical Variables ◽  
Nutrition Examination Survey ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Self Rated Health ◽  
Health And Nutrition ◽  
Hs Crp

Abstract Background No studies have investigated the association between self-rated health (SRH) and high-sensitivity C-reactive protein (hs-CRP) levels in South Koreans. We explored this association and analyzed differences between sexes. Methods Using cross-sectional data from the 2015–2017 Korea National Health and Nutrition Examination Survey, we analyzed the association between SRH and high hs-CRP levels (> 1.0 mg/L) in 14,544 Koreans aged ≥ 19 years who responded to the SRH survey and had available hs-CRP test results. Differences in sociodemographic factors were analyzed using the Pearson’s chi-square test for categorical variables or the Mann–Whitney U test for continuous variables. Multiple logistic regression analysis was used to measure the association between hs-CRP levels and SRH according to sex while adjusting for other possible confounders. Results The percentage of very poor to poor SRH was higher in the high hs-CRP group (22.4%) than in the low hs-CRP group (17.66%). Among men, the risk of a high hs-CRP level increased with worse SRH (adjusted for confounders; P for trend < 0.001). After adjusting for all confounders, including chronic diseases, men with very poor SRH showed a higher odds ratio (OR) for high hs-CRP levels than those with very good SRH (fully adjusted OR, 1.74; 95% CI, 1.04–2.90). Significant correlations were absent among women. Conclusions Poor SRH was correlated with low-grade inflammation (high hs-CRP levels) among Korean male adults. These findings could be useful for developing health improvement programs and in goal setting at a national scale.

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