scholarly journals STAT3 imparts BRCAness by impairing homologous recombination repair in Epstein-Barr virus-transformed B lymphocytes

2020 ◽  
Vol 16 (10) ◽  
pp. e1008849
Author(s):  
Michael T. McIntosh ◽  
Siva Koganti ◽  
J. Lucas Boatwright ◽  
Xiaofan Li ◽  
Salvatore V. Spadaro ◽  
...  
Keyword(s):  
Homologous Recombination ◽  
B Lymphocytes ◽  
Epstein Barr Virus ◽  
Homologous Recombination Repair ◽  
Barr Virus ◽  
Recombination Repair ◽  
Epstein Barr

scholarly journals Immunization with Epstein–Barr Virus Core Fusion Machinery Envelope Proteins Elicit High Titers of Neutralizing Activities and Protect Humanized Mice from Lethal Dose EBV Challenge

Vaccines ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 285
Author(s):  
Xinle Cui ◽  
Zhouhong Cao ◽  
Yuriko Ishikawa ◽  
Sara Cui ◽  
Ken-Ichi Imadome ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
B Lymphocytes ◽  
Neutralizing Antibodies ◽  
Epstein Barr Virus ◽  
Lethal Dose ◽  
Envelope Proteins ◽  
Humanized Mice ◽  
Target Cells ◽  
Barr Virus ◽  
Epstein Barr

Epstein–Barr virus (EBV) is the primary cause of infectious mononucleosis and is strongly implicated in the etiology of multiple lymphoid and epithelial cancers. EBV core fusion machinery envelope proteins gH/gL and gB coordinately mediate EBV fusion and entry into its target cells, B lymphocytes and epithelial cells, suggesting these proteins could induce antibodies that prevent EBV infection. We previously reported that the immunization of rabbits with recombinant EBV gH/gL or trimeric gB each induced markedly higher serum EBV-neutralizing titers for B lymphocytes than that of the leading EBV vaccine candidate gp350. In this study, we demonstrated that immunization of rabbits with EBV core fusion machinery proteins induced high titer EBV neutralizing antibodies for both B lymphocytes and epithelial cells, and EBV gH/gL in combination with EBV trimeric gB elicited strong synergistic EBV neutralizing activities. Furthermore, the immune sera from rabbits immunized with EBV gH/gL or trimeric gB demonstrated strong passive immune protection of humanized mice from lethal dose EBV challenge, partially or completely prevented death respectively, and markedly decreased the EBV load in peripheral blood of humanized mice. These data strongly suggest the combination of EBV core fusion machinery envelope proteins gH/gL and trimeric gB is a promising EBV prophylactic vaccine.

scholarly journals Activated or dominant inhibitory mutants of Rap1A decrease the oxidative burst of Epstein-Barr virus-transformed human B lymphocytes.

1994 ◽  
Vol 269 (29) ◽  
pp. 18743-18746 ◽  
Author(s):  
F.E. Maly ◽  
L.A. Quilliam ◽  
O. Dorseuil ◽  
C.J. Der ◽  
G.M. Bokoch
Keyword(s):  
B Lymphocytes ◽  
Oxidative Burst ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals The interplay between Epstein–Barr virus and B lymphocytes: implications for infection, immunity, and disease

2014 ◽  
Vol 58 (2-3) ◽  
pp. 268-276 ◽  
Author(s):  
Olivia L. Hatton ◽  
Aleishia Harris-Arnold ◽  
Steven Schaffert ◽  
Sheri M. Krams ◽  
Olivia M. Martinez
Keyword(s):  
B Lymphocytes ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Epstein Barr

Epstein-Barr Virus Transformation of B Lymphocytes: Molecular Pathogenesis

1989 ◽  
pp. 3-15
Author(s):  
David Liebowitz ◽  
Elliott Kieff ◽  
Jeffery Sample ◽  
Mark Birkenbach ◽  
Fred Wang
Keyword(s):  
B Lymphocytes ◽  
Epstein Barr Virus ◽  
Molecular Pathogenesis ◽  
Barr Virus ◽  
Virus Transformation ◽  
Epstein Barr

Epstein-Barr Virus-Transformed Human B Lymphocytes Endocytose Autologous and Heterologous Red Blood Cells

1989 ◽  
Vol 88 (3) ◽  
pp. 312-316
Author(s):  
Carlo Garzelli ◽  
Antonio Marchetti ◽  
Anna Pacciardi ◽  
Carla Puglisi ◽  
Fulvio Basolo
Keyword(s):  
Red Blood Cells ◽  
B Lymphocytes ◽  
Blood Cells ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Epstein Barr
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